A cytokinesis furrow is positioned by two consecutive signals

Bringmann, Henrik; Hyman, Anthony A.

doi:10.1038/nature03823

Cited by 206 publications

(211 citation statements)

References 26 publications

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“…Thus in this assay, the position midway between the asters and the position of the spindle midzone are spatially separated. We term this assay asymmetric spindle severing (ASS) 5 (Fig. 1A and B).…”

Section: Cytokinesis Furrow Positioning By the Mitotic Spindlementioning

confidence: 99%

Cytokinesis and the Spindle Midzone

Bringmann

2005

Cell Cycle

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Section: Cytokinesis Furrow Positioning By the Mitotic Spindlementioning

confidence: 99%

Cytokinesis and the Spindle Midzone

Bringmann

2005

Cell Cycle

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“…Genetic studies in Drosophila and C. elegans, and RNAi studies in mammalian cells, show beyond doubt that proteins localized to the central spindle have an essential role at least in maintenance of the cytokinetic apparatus, and probably also in its induction (Bringmann and Hyman, 2005;D'Avino et al, 2006;Dechant and Glotzer, 2003;Jantsch-Plunger et al, 2000;Mishima et al, 2002;Nishimura and Yonemura, 2006;Somers and Saint, 2003;Yuce et al, 2005). The small GTPase RhoA has emerged as an essential physiological link between the geometry of the mitotic apparatus and cytokinetic furrow induction in diverse cells (Bement et al, 2005;Dean et al, 2005;Jantsch-Plunger et al, 2000;Yuce et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

“…Dechant and Glotzer (Dechant and Glotzer, 2003) showed that the central spindle only becomes essential for furrow initiation if the asters are closer than normal after anaphase, and concluded that the central spindle acts redundantly with a cue based on astral microtubule density. An elegant study by Bringmann and Hyman (Bringmann and Hyman, 2005) suggests that in C. elegans both asters and central spindle can separately induce furrowing, but the central spindle cue is both later-acting and dominant. Finally, Werner et al (Werner et al, 2007) showed conclusively that two furrowing cues can be genetically or spatially separated in C. elegans zygotes.…”

Section: Introductionmentioning

confidence: 99%

Cytokinetic furrowing in toroidal, binucleate and anucleate cells inC. elegansembryos

Baruni

Munro

Dassow

2008

Journal of Cell Science

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Classical experimental studies on echinoderm zygotes concluded that the juxtaposition of two astral microtubule arrays localizes the stimulus for cytokinetic furrowing. However, recent experimental and genetic studies in Caenorhabditis elegans, Drosophila and mammalian cultured cells implicate microtubules of the central spindle, and regulatory proteins associated with this structure, suggesting that the essential conditions for furrow induction may differ from one animal cell to another. We used micromanipulation and laser microsurgery to create, in three ways, the juxtaposition of astral microtubules in C. elegans embryonic cells. In toroidal cells we observe that furrows initiate both where astral microtubule arrays are juxtaposed, and where the cortex most closely approaches the central spindle. We find that binucleate cells successfully furrow not only across the spindles, but also between unconnected spindle poles. Finally, we find that anucleate cells containing only a pair of centrosomes nevertheless attempt to cleave. Therefore, in C. elegans embryonic cells, as in echinoderms, juxtaposition of two asters suffices to induce furrowing, and neither the chromatin nor the physical structure of the central spindle are indispensable for furrow initiation. However, furrows that cross a central spindle are more likely to complete than those that do not.

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“…Typically, the position of the mitotic spindle determines the site of cytokinesis, and physically moving a spindle can change the cytokinesis plane [4,5]. Both astral and midzone microtubules are required to determine the cleavageplane site [6].…”

Section: Symmetrically Dividing Cellsmentioning

confidence: 99%

Coordinating cell polarity with cell division in space and time

Panbianco

Gotta

2011

Trends in Cell Biology

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Decisions of when and where to divide are crucial for cell survival and fate, and for tissue organization and homeostasis. The temporal coordination of mitotic events during cell division is essential to ensure that each daughter cell receives one copy of the genome. The spatial coordination of these events is also crucial because the cytokinetic furrow must be aligned with the axis of chromosome segregation and, in asymmetrically dividing cells, the polarity axis. Several recent papers describe how cell shape and polarity are coordinated with cell division in single cells and tissues and begin to unravel the underlying molecular mechanisms, revealing common principles and molecular players. Here, we discuss how cells regulate the spatial and temporal coordination of cell polarity with cell division

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A cytokinesis furrow is positioned by two consecutive signals

Cited by 206 publications

References 26 publications

Cytokinesis and the Spindle Midzone

Cytokinesis and the Spindle Midzone

Cytokinetic furrowing in toroidal, binucleate and anucleate cells inC. elegansembryos

Coordinating cell polarity with cell division in space and time

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