Coordinating cell polarity with cell division in space and time

Panbianco, Costanza Viola Sofia; Gotta, Monica

doi:10.1016/j.tcb.2011.08.006

Cited by 15 publications

(14 citation statements)

References 63 publications

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“…Cell shape and polarity also have a profound effect on the outcome of cell divisions, and thus differentiation decisions, with cleavage-plane orientation determining whether divisions will be symmetric (producing identical daughter cells), or asymmetric (producing daughters with different fates) [reviewed in 82]. It is not surprising then, that the significance of cell junctions and polarity complexes in modulating Hippo signaling has become increasingly apparent [reviewed in 12–14].…”

Section: Discussionmentioning

confidence: 99%

The Hippo signaling pathway and stem cell biology

Ramos

Camargo

2012

Trends in Cell Biology

249

226

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Stem cell activity fluctuates throughout an organism’s lifetime to maintain homeostatic conditions in all tissues. As animals develop and age, their organs must remodel and regenerate themselves in response to environmental and physiological demands. Recently, the highly conserved Hippo signaling pathway, discovered in Drosophila melanogaster, has been implicated as a key regulator of organ size control across species. Deregulation is associated with substantial overgrowth phenotypes and eventual onset of cancer in various tissues. Importantly, emerging evidence suggests that the Hippo pathway can modulate its effects on tissue size by the direct regulation of stem cell proliferation and maintenance. These findings provide an attractive model for how this pathway might communicate physiological needs for growth to tissue-specific stem cell pools. In this review, we summarize the current and emerging data linking Hippo signaling to stem cell function

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Section: Discussionmentioning

confidence: 99%

The Hippo signaling pathway and stem cell biology

Ramos

Camargo

2012

Trends in Cell Biology

249

226

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“…In Drosophila neuroblasts, microtubule‐tethering complexes, similar to those described for C. elegans , form at the apical cortex prior to metaphase to position the mitotic spindle (Fig. B) [Siller and Doe, ; Panbianco and Gotta, ; Lu and Johnston, ]. Mutations in proteins required for spindle alignment cause divisions to occur symmetrically, leading to altered cell fates and an increase in the number of neuroblasts at the expense of GMCs.…”

Section: Polarizing Cells To Determine Fatementioning

confidence: 99%

Microtubules and actin crosstalk in cell migration and division

2013

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Crosstalk between the actin cytoskeleton and microtubules promotes symmetry break to polarize cells for division, shape changes, and migration. These cellular events are crucial for forming tissues, and drive the metastasis of cancer cells. Rho GTPases mediate the formation of different types of F‐actin that confer changes in cortical tension and contraction, and can be regulated by microtubules. For example, central spindle microtubules of the mitotic spindle stimulate RhoA activity to form long, unbranched F‐actin that is crosslinked by nonmuscle myosin to form the contractile ring in the equatorial plane of the cell. There is greater cortical tension in this area of the cell in comparison to the poles, where the formation of short, branched F‐actin is favored. In migrating cells, growing microtubules that reach into the leading edge promote Rac activation and the formation of short, branched F‐actin for lamellipodia formation. A common theme that is emerging in many fields is that feedback can also occur from the cortex to alter microtubule stability. In this manner, cells can dynamically respond to intrinsic or extrinsic cues to ensure that their division plane is always coupled with the segregation of DNA and cell fate determinants, or that they migrate properly to form a tissue. © 2013 Wiley Periodicals, Inc.

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“…The early C. elegans embryo is an attractive model system for studying the mechanisms coupling cell polarity and cell cycle timing regulation [7,49]. Like X. laevis and D. melanogaster , the embryonic cell division cycles in C. elegans consist of rapid phases of DNA replication alternating with mitosis, without intervening gap phases (figure 1 a ).…”

Section: Coupling Cell Polarity and Cell Cycle Progression In Caenorhmentioning

confidence: 99%

Coordinating cell polarity and cell cycle progression: what can we learn from flies and worms?

et al. 2013

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Spatio-temporal coordination of events during cell division is crucial for animal development. In recent years, emerging data have strengthened the notion that tight coupling of cell cycle progression and cell polarity in dividing cells is crucial for asymmetric cell division and ultimately for metazoan development. Although it is acknowledged that such coupling exists, the molecular mechanisms linking the cell cycle and cell polarity machineries are still under investigation. Key cell cycle regulators control cell polarity, and thus influence cell fate determination and/or differentiation, whereas some factors involved in cell polarity regulate cell cycle timing and proliferation potential. The scope of this review is to discuss the data linking cell polarity and cell cycle progression, and the importance of such coupling for asymmetric cell division. Because studies in model organisms such as Caenorhabditis elegans and Drosophila melanogaster have started to reveal the molecular mechanisms of this coordination, we will concentrate on these two systems. We review examples of molecular mechanisms suggesting a coupling between cell polarity and cell cycle progression.

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Coordinating cell polarity with cell division in space and time

Cited by 15 publications

References 63 publications

The Hippo signaling pathway and stem cell biology

The Hippo signaling pathway and stem cell biology

Microtubules and actin crosstalk in cell migration and division

Coordinating cell polarity and cell cycle progression: what can we learn from flies and worms?

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