A cyclic brush zwitterionic polymer based pH-responsive nanocarrier-mediated dual drug delivery system with lubrication maintenance for osteoarthritis treatment

Zhang, Miao; Xu, Ping; Yuan, Di; Ke, Xiang; Ren, Kai; Xin, Qiangwei; Meng, Qingcai; Xie, Jun; Li, Jianshu

doi:10.1039/d3mh00218g

Cited by 13 publications

(10 citation statements)

References 66 publications

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“…Based on previous studies, curcumin has good antioxidation, anti-inflammatory, antiapoptotic, and other biological activities. , At the same time, some reports confirm that in diabetic skin defects, curcumin can effectively reduce the production of reactive oxygen species (ROS) in tissues and inhibit cell oxidative damage . In order to verify whether Exos-cur can effectively inhibit the production of ROS, we first tested the effect of different concentrations of high sugar (HG) on HUVECs with the cck-8 kit (Figure A).…”

Section: Resultsmentioning

confidence: 99%

Curcumin-Loaded Macrophage-Derived Exosomes Effectively Improve Wound Healing

Zhang

Gao

et al. 2023

Mol. Pharmaceutics

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This study aims to investigate the potential therapeutic effect of exosomes derived from macrophages loaded with curcumin (Exos-cur) on the healing of diabetic wounds. As a new type of biomaterial, Exos-cur has better stability, antiinflammation, and antioxidation biological activity. In in vitro experiments, Exos-cur can promote the proliferation, migration, and angiogenesis of HUVECs (human umbilical vein endothelial cells) while reducing the ROS (reactive oxygen species) produced by HUVECs induced by high glucose, regulating the mitochondrial membrane potential, reducing cell oxidative damage, and inhibiting oxidative stress and inflammation. In the in vivo experiment, the Exos-cur treatment group had an increased percentage of wound closure and contraction compared with the diabetic wound control group. Hematoxylin−eosin staining (HE) and Masson staining showed that the Exos-cur treatment group had more advanced reepithelialization, and the generated mature granulation tissue was rich in a large number of capillaries and newly deposited collagen fibers. Western blot and immunofluorescence analyses showed that Exos-cur can inhibit inflammation by activating the Nrf2/ARE pathway, upregulate the expression of wound healing-related molecules, promote angiogenesis, and accelerate wound healing in diabetic rats. These results show that Exos-cur has a good therapeutic effect on diabetic skin defects and provide experimental evidence for the potential clinical benefits of Exos-cur.

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Section: Resultsmentioning

confidence: 99%

Curcumin-Loaded Macrophage-Derived Exosomes Effectively Improve Wound Healing

Zhang

Gao

et al. 2023

Mol. Pharmaceutics

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“…[5,11,12] Moreover, the cyclic characteristic offers opportunities for designing materials with tailored properties and applications in various fields, including drug delivery systems, surface functionalization, and other materials. [8,[13][14][15][16][17] As a result, there is a growing interest in the synthesis, physical properties, and functions of cyclic DOI: 10.1002/marc.202300628 polymers. Among them, bicyclic polymer was a type of complex polymer, which consists of two covalently linked macro rings, and has received particular attention.…”

Section: Introductionmentioning

confidence: 99%

Polyacetylene‐Based Asymmetric Bicyclic Polymer by Blocking‐Cyclization Technique

Ma,

Wang,

Sun

et al. 2024

Macromol. Rapid Commun.

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A rare asymmetric bicyclic polymer containing different length of conjugated polyacetylene segments was synthesized by metathesis cyclopolymerization‐mediated blocking‐cyclization technique. The size of each single ring differed from each other, and the unique cyclic polymer topology was controlled by adjusting the feed ratio of monofunctional monomer to catalyst. The topological difference between linear and bicyclic polymers was confirmed by several techniques, and the visualized morphology of asymmetric bicyclic polymer was directly observed without tedious post‐modification process. The photoelectric and thermal properties of polymers were investigated. This work expanded the pathway for the derivation of cyclic polymers, and such unique topological structure enriched the diversity of cyclic polymer classes.This article is protected by copyright. All rights reserved

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“…19−21 Nanoparticle-or microsphere-based lubricant systems for drug delivery or anti-inflammatory activities have also been widely fabricated, and while most of these use nonspecific cartilage tissue-binding lubricants, several systems showed potential for OA treatment, but whether they could prevent OA remains unclear. 11,22,23 Therefore, bioinspired lubricants with both specific cartilage-binding performance and OA prevention potential have rarely been reported. Synovial inflammation, which immediately follows the increase in cartilage friction, has been observed in the early stages of OA and contributes to its pathogenesis.…”

Section: Introductionmentioning

confidence: 99%

A Dual Functional Bioinspired Lubricant for Osteoarthritis Treatment and Potential Prevention

Yan,

Yang,

Liu

et al. 2024

ACS Appl. Mater. Interfaces

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Osteoarthritis (OA), primarily characterized by the deterioration of articular cartilage, is a highly prevalent joint-disabling disease. The pathological onset and progression of OA are closely related to cartilage lubrication dysfunction and synovial inflammation. Synergistic options targeted at restorative lubrication and antiinflammation are expected to be the most attractive candidates to treat OA and perhaps help prevent it. Herein, a bioinspired lubricant (HA/ PA@Lipo) was fabricated by combining anionic hyaluronan-graf tpoly(2-acrylamide-2-methylpropanesulfonic acid sodium salt) (HA/PA) with cationic liposomes (Lipo) via electrostatic interaction. HA/PA@ Lipo mimicked the lubrication complex located on the outer cartilage surface and was endowed cartilage with excellent cartilage-lubricating performances. After the antioxidant gallic acid (GA) was loaded for dual functionality, HA

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A cyclic brush zwitterionic polymer based pH-responsive nanocarrier-mediated dual drug delivery system with lubrication maintenance for osteoarthritis treatment

Abstract: Enhanced joint synergistic lubrication combined with anti-inflammatory therapy is an effective strategy to delay the progression of early osteoarthritis (OA) but rarely reported. Based on the hydration lubrication of zwitterion...

Cited by 13 publications

References 66 publications

Curcumin-Loaded Macrophage-Derived Exosomes Effectively Improve Wound Healing

Curcumin-Loaded Macrophage-Derived Exosomes Effectively Improve Wound Healing

Polyacetylene‐Based Asymmetric Bicyclic Polymer by Blocking‐Cyclization Technique

A Dual Functional Bioinspired Lubricant for Osteoarthritis Treatment and Potential Prevention

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