A CRY-DASH-type photolyase/cryptochrome from Sclerotinia sclerotiorum mediates minor UV-A-specific effects on development

Veluchamy, Selvakumar; Rollins, Jeffrey A.

doi:10.1016/j.fgb.2008.06.004

Cited by 53 publications

(43 citation statements)

References 73 publications

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“…Searching the Phycomyces genome database for genes encoding proteins of the CPF, we found only one gene encoding a protein (ID no. 85761) similar to N. crassa CRY (25) and S. sclerotiorum Cry1 (28). The absence of a canonical photolyase gene in the Phycomyces genome suggested that the cryptochrome gene, cryA, could encode a protein that acts as a photolyase.…”

Section: Resultsmentioning

confidence: 98%

“…Sensory roles have been proposed for fungal CPF members (16,17,28,29), and it is possible that Phycomyces CryA plays an additional role as a photoreceptor. However, none of the mutants affected in phototropism have a mutation in cryA, arguing against a sensory role for CryA, at least for the phototropism of the fruiting body, and suggesting that the main role of CryA is to act as a photolyase.…”

Section: Discussionmentioning

confidence: 99%

“…Cry-DASH have been described in other fungi and they have minor sensory roles. They participate in the regulation by light of development in Sclerotinia sclerotiorum and Fusarium fujikuroi (28,29), and pigment accumulation in F. fujikuroi (29).…”

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confidence: 99%

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Fungal cryptochrome with DNA repair activity reveals an early stage in cryptochrome evolution

Tagua

Pausch

Eckel

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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DASH (Drosophila, Arabidopsis, Synechocystis, Human)-type cryp- tochromes (cry-DASH) belong to a family of flavoproteins acting as repair enzymes for UV-B–induced DNA lesions (photolyases) or as UV-A/blue light photoreceptors (cryptochromes). They are present in plants, bacteria, various vertebrates, and fungi and were originally considered as sensory photoreceptors because of their incapability to repair cyclobutane pyrimidine dimer (CPD) lesions in duplex DNA. However, cry-DASH can repair CPDs in single-stranded DNA, but their role in DNA repair in vivo remains to be clarified. The genome of the fungus Phycomyces blakesleeanus contains a single gene for a protein of the cryptochrome/photolyase family (CPF) encoding a cry-DASH, cryA, despite its ability to photoreactivate. Here, we show that cryA expression is induced by blue light in a Mad complex-dependent man- ner. Moreover, we demonstrate that CryA is capable of binding flavin (FAD) and methenyltetrahydrofolate (MTHF), fully complements the Escherichia coli photolyase mutant and repairs in vitro CPD lesions in single-stranded and double-stranded DNA with the same efficiency. These results support a role for Phycomyces cry-DASH as a photolyase and suggest a similar role for cry-DASH in mucoromycotina fung

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Section: Resultsmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

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Fungal cryptochrome with DNA repair activity reveals an early stage in cryptochrome evolution

Tagua

Pausch

Eckel

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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“…A couple of fungal photolyase/ cryptochrome from ascomycetes and basidiomycetes have been recently investigated (Berrocal-Tito et al, 2007;Bluhm and Dunkle, 2008;Froehlich et al, 2010;Veluchamy and Rollins, 2008). As in other organisms, most fungi possess more than one gene of the photolyase/cryptochrome family.…”

Section: Blue and Uva Light Sensing -The Cryptochrome/photolyase Cryamentioning

confidence: 99%

Spotlight on Aspergillus nidulans photosensory systems

Bayram

Braus

Fischer

et al. 2010

Fungal Genetics and Biology

149

148

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“…Cryptochromes, blue-light receptors that function exclusively in signal transduction, have been well-characterized in plants and animals (Lin and Todo, 2005), although much less is known about structurally similar proteins in fungi Borkovich et al, 2004;Veluchamy and Rollins, 2008). A recent study identified PHL1, a cryptochrome/6−4 photolyase-like gene in C. zeae-maydis ; disruption of PHL1 abolished photoreactivation after exposure to UV light.…”

Section: Cercospora Zeae-maydis Causes Gray Leaf Spot Of Maizementioning

confidence: 99%

Regulation of Pathogenesis by Light in Cercospora zeae-maydis: An Updated Perspective

Kim¹,

Ridenour²,

Dunkle³

et al. 2011

The Plant Pathology Journal

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The fungal genus Cercospora is one of the most ubiquitous groups of plant pathogenic fungi, and gray leaf spot caused by C. zeae-maydis is one of the most widespread and damaging foliar diseases of maize in the world. While light has been implicated as a critical environmental regulator of pathogenesis in C. zeae-maydis, the relationship between light and the development of disease is not fully understood. Recent discoveries have provided new insights into how light influences pathogenesis and morphogenesis in C. zeae-maydis, particularly at the molecular level. This review is focused on integrating old and new information to provide an updated perspective of how light influences pathogenesis, and provides a working model to explain some of the underlying molecular mechanisms. Ultimately, a thorough molecular-level understanding of how light regulates pathogenesis will augment efforts to manage gray leaf spot by improving host resistance and disease management strategies.

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A CRY-DASH-type photolyase/cryptochrome from Sclerotinia sclerotiorum mediates minor UV-A-specific effects on development

Cited by 53 publications

References 73 publications

Fungal cryptochrome with DNA repair activity reveals an early stage in cryptochrome evolution

Fungal cryptochrome with DNA repair activity reveals an early stage in cryptochrome evolution

Spotlight on Aspergillus nidulans photosensory systems

Regulation of Pathogenesis by Light in Cercospora zeae-maydis: An Updated Perspective

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