A Critical Review on the Design, Manufacturing and Assessment of the Bone Scaffold for Large Bone Defects

Huo, Yi; Lü, Yongtao; Meng, Lei; Wu, Jiongyi; Gong, Tingxiang; Zou, Jia’ao; Босяков, Сергей Михайлович; Cheng, Liangliang

doi:10.3389/fbioe.2021.753715

Cited by 18 publications

(9 citation statements)

References 74 publications

(77 reference statements)

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“…Autograft transplantation is limited by insufficient bone supply and high incidence rate of donor site infections, while allograft transplantation may lead to potential risks like disease transmission. 5 Bone tissue engineering is an effective method to treat bone defects and guide bone regeneration using scaffolds both as a substrate for the localization and growth of bone-forming cells and as a carrier of growth factors. 6,7 The success of bone tissue engineering heavily depends on the construction of suitable scaffolds.…”

Section: Introductionmentioning

confidence: 99%

Protein–inorganic hybrid porous scaffolds for bone tissue engineering

Sun

Yao

et al. 2022

J. Mater. Chem. B

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Section: Introductionmentioning

confidence: 99%

Protein–inorganic hybrid porous scaffolds for bone tissue engineering

Sun

Yao

et al. 2022

J. Mater. Chem. B

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“…The development of BTE materials requires the continuous improvement of porous bone scaffolds with appropriate mechanical properties and suitable porosity to promote cell attachment and proliferation [ 5 ]. Moreover, incorporating growth factor molecules could even facilitate quality bone formation [ 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Novel Epigenetic Modulation Chitosan-Based Scaffold as a Promising Bone Regenerative Material

Sukpaita

Chirachanchai

Chanamuangkon

et al. 2022

Cells

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Bone tissue engineering is a complicated field requiring concerted participation of cells, scaffolds, and osteoactive molecules to replace damaged bone. This study synthesized a chitosan-based (CS) scaffold incorporated with trichostatin A (TSA), an epigenetic modifier molecule, to achieve promising bone regeneration potential. The scaffolds with various biphasic calcium phosphate (BCP) proportions: 0%, 10%, 20%, and 40% were fabricated. The addition of BCP improved the scaffolds’ mechanical properties and delayed the degradation rate, whereas 20% BCP scaffold matched the appropriate scaffold requirements. The proper concentration of TSA was also validated. Our developed scaffold released TSA and sustained them for up to three days. The scaffold with 800 nM of TSA showed excellent biocompatibility and induced robust osteoblast-related gene expression in the primary human periodontal ligament cells (hPDLCs). To evaluate in vivo bone regeneration potential, the scaffolds were implanted in the mice calvarial defect model. The excellent bone regeneration ability was further demonstrated in the micro-CT and histology sections compared to both negative control and commercial bone graft product. New bone formed in the CS/BCP/TSA group revealed a trabeculae-liked characteristic of the mature bone as early as six weeks. The CS/BCP/TSA scaffold is an up-and-coming candidate for the bone tissue engineering scaffold.

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“…A clinically applicable scaffold needs to simultaneously possess some specific features such as biocompatibility, biodegradability, osteoconductivity, low immunogenicity and non-infectivity [ 42 ]. The development of a biocompatible biomaterial with appropriate physicochemical and mechanical properties still poses a great challenge for researchers [ 38 ], and further developments are still needed, especially in considering the dynamic interaction between scaffolds and tissues, in improving the quality of scaffold manufacturing and in evaluating the material performances [ 43 ], focusing on the relationship between key features and fabrication techniques to develop biomaterials with the hierarchical structure of the natural bone tissue [ 41 ].…”

Section: Traditional and Novel Approaches In Bone Tissue Engineeringmentioning

confidence: 99%

Novel Approaches and Biomaterials for Bone Tissue Engineering: A Focus on Silk Fibroin

Paladini

Pollini

2022

Materials

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Bone tissue engineering (BTE) represents a multidisciplinary research field involving many aspects of biology, engineering, material science, clinical medicine and genetics to create biological substitutes to promote bone regeneration. The definition of the most appropriate biomaterials and structures for BTE is still a challenge for researchers, aiming at simultaneously combining different features such as tissue generation properties, biocompatibility, porosity and mechanical strength. In this scenario, among the biomaterials for BTE, silk fibroin represents a valuable option for the development of functional devices because of its unique biological properties and the multiple chances of processing. This review article aims at providing the reader with a general overview of the most recent progresses in bone tissue engineering in terms of approaches and materials with a special focus on silk fibroin and the related mechanisms involved in bone regeneration, and presenting interesting results obtained by different research groups, which assessed the great potential of this protein for bone tissue engineering.

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A Critical Review on the Design, Manufacturing and Assessment of the Bone Scaffold for Large Bone Defects

Cited by 18 publications

References 74 publications

Protein–inorganic hybrid porous scaffolds for bone tissue engineering

Protein–inorganic hybrid porous scaffolds for bone tissue engineering

Novel Epigenetic Modulation Chitosan-Based Scaffold as a Promising Bone Regenerative Material

Novel Approaches and Biomaterials for Bone Tissue Engineering: A Focus on Silk Fibroin

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