A Critical Review of the Properties of Fusidic Acid and Analytical Methods for Its Determination

Abstract

Fusidic acid, an antibiotic produced from the Fusidium coccineum fungus, belongs to the class of steroids, but has no corticosteroid effects. It is indicated for the treatment of infections caused by methicillin-resistant Staphylococcus aureus strains. The aim of this study was to search for the properties of fusidic acid published so far in the literature, as well as the methods developed for its determination in biological samples and pharmaceutical formulations. From the findings, we can conclude that fusidic acid has been used for decades and is indicated for the treatment of serious infections caused by Gram-positive microorganisms to this day. Furthermore, it is a hypoallergenic agent, has low toxicity, shows low resistance, and has no cross-resistance with other clinically used antibiotics. The analytical method of high-performance liquid chromatography has been widely used for determining fusidic acid, since it can reduce the cost and time of analysis, making it more viable for routine quality control in the pharmaceutical industry.

Isoniazid: A Review of Characteristics, Properties and Analytical Methods

“…Chromatographic techniques, especially those involving HPLC are widely used in pharmaceutical analysis (Corrêa and Salgado, 2011;Bonfilio et al, 2012;Chierentin and Salgado, 2016;Curbete and Salgado, 2016;Fernandes and Salgado, 2016;Pedroso and Salgado, 2016). A number of detectors coupled with HPLC systems are currently used, such as ultraviolet-visible (UV) spectrophotometry, fluorescence methods, MS, and electrochemical methods (Bonfilio et al, 2010).…”

Mycobiome in the Gut: A Multiperspective Review

“…Fungi also possess great potential in producing a broad spectrum of metabolites, which can be applied for medication or therapeutic purposes. For example, griseofulvin isolated from Penicillium griseofulvum served as antimycotic drug [85], while fusidic acid from Fusidium coccineum [86] and cephalosporins from Acremonium chrysogenum act as antibacterial agents, and lovastatin isolated from Aspergillus terreus and mevastatin from Penicillium citrinum [87] can be used as lipid lowering agents. Besides this, similar like bacteria, fungi can express metabolites which can influence host homeostasis and exert biological effects on host, as part of fungi-host interactions [17].…”

Evolving concepts and emerging solutions to the problem of staphylococcal infection in dermatology

“…Позднее оказалось, что синтезировать молекулу могут также отдельные виды таких разных плесеней, как Acremonium, Cephalosporium, Paecilomyces, Mucor и даже дерматофит Epidermophyton floccosum [80], что может свидетельствовать о роли фузиданов как бактериоцинов, сформировавшихся в ходе эволюции и конкурентной борьбы микроорганизмов. С этой точки зрения могут иначе представляться новые данные, полученные о свойстве фузидовой кислоты подавлять образование биопленок, потенцируя действие других противомикробных соединений [81], а также об угнетении механизмов вирулентности стафилококков уже субингибиторными (т.е.…”

“…Важность этих сведений, а также изучения механизмов резистентности возрастает с учетом того, что препараты фузидовой кислоты рассматриваются и как средство преодоления MRSAрезистентности [80]. Кроме того, препараты фузидовой кислоты традиционно признаются одними из самых безопасных антибиотиков для наружного применения [83].…”