A cost benefit analysis of routine varicella vaccination in Spain

Díez-Domingo, Javier; Ridao, Manuel; Latour, Jos M.; Ballester, Alfredo; Morant, A

doi:10.1016/s0264-410x(98)00394-6

Cited by 95 publications

(41 citation statements)

References 17 publications

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“…The vaccine has been licensed in many countries and in 1995 was introduced into the routine immunization schedule for healthy children in the United States [9]. Many other countries are currently studying the possibility of mass vaccination [10][11][12][13][14][15]. However, some important questions remain which limit the widespread acceptability of the vaccine in these countries.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of varicella zoster virus infection in Canada and the United Kingdom

et al. 2001

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SUMMARYMany countries are currently studying the possibility of mass vaccination against varicella. The objective of this study was to provide a comprehensive picture of the pre-vaccine epidemiology of the varicella zoster virus (VZV) to aid in the design of immunization programs and to adequately measure the impact of vaccination. Population-based data including physician visit claims, sentinel surveillance and hospitalization data from Canada and the United Kingdom were analysed. The key epidemiological characteristics of varicella and zoster (age specific consultation rates, seasonality, force of infection, hospitalization rates and inpatient days) were compared. Results show that the overall epidemiology of varicella and zoster is remarkably similar between the two countries. The major difference being that, contrary to Canada, the epidemiology of varicella seems to be changing in the United Kingdom with an important decrease in the average age at infection that coincides with a significant increase in children attending preschool. Furthermore, differences exist in the seasonality between the United Kingdom and Canada, which seem to be primarily due to the school calendar. These results illustrate that school and preschool contact patterns play an important role in the dynamics of varicella. Finally, our results provide baseline estimates of varicella and zoster incidence and morbidity for VZV vaccine effectiveness and cost-effectiveness studies.

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Section: Introductionmentioning

confidence: 99%

Epidemiology of varicella zoster virus infection in Canada and the United Kingdom

et al. 2001

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“…The vaccine has been shown to be cost-effective in a number of studies in the developed world (12,14,21,31,33,97). In general, VZV vaccine is geared for use in developed countries, where chickenpox has a significant economic impact due to parental absence from work.…”

Section: Effectiveness Of Varicella Vaccine and Its Impact In The Unimentioning

confidence: 99%

Preventing Varicella-Zoster Disease

2005

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Varicella-zoster virus (VZV), the cause of chickenpox and shingles, is a pathogen in retreat following the introduction of mass vaccination in the United States in 1995. The live attenuated Oka vaccine, which is safe and immunogenic, gives good protection against both varicella and zoster in the short to medium term. It has undoubtedly been highly effective to date in reducing all forms of varicella, especially severe disease. However, the huge pool of latent wild-type virus in the population represents a continuing threat. Both the biology and the epidemiology of VZV disease suggest that new vaccination strategies will be required over time

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“…Table 3 summarizes the various models' characteristics. Of all the studies reviewed, 10 used dynamic models 29,30,36,40,42,43,45,48,51,52 , 16 used static models 25,26,27,28,32,33,34,35,38,39,41,44,46,47,49,50 , and one study used a pseudodynamic model 37 . The latter model was considered pseudodynamic because it did not incorporate the indirect effects of vaccination on the entire population, but appears to have applied reduced forces of infection to susceptible individuals in the vaccinated cohorts 2 .…”

Section: Results Of Literature Searchmentioning

confidence: 99%