A copper(II) complex of 1,10-phenanthroline and enrofloxacin

Abstract

The asymmetric unit of the title complex, aqua[1‐cyclopropyl‐7‐(4‐ethylpiperazin‐1‐yl)‐6‐fluoro‐4‐oxo‐1,4‐dihydroquinoline‐3‐carboxylato](1,10‐phenanthroline)copper(II) nitrate dihydrate, [Cu(C19H21FN3O3)(C12H8N2)(H2O)]NO3·2H2O, contains one [Cu(erx)(phen)(H2O)]+ cation, one NO3− anion and two solvent water molecules (erx is enrofloxacin and phen is 1,10‐phenanthroline). The CuII ion adopts a slightly distorted square‐pyramidal geometry, coordinated by two O atoms of the erx ligand and two N atoms of the phen ligand in the basal plane, and by a water molecule in the apical position. The CuII ion deviates from the basal plane by 0.1439 (7) Å. The piperazine ring belonging to erx has a slightly twisted chair conformation. Coordinated and uncoordinated water molecules participate in a hydrogen‐bonding network including both cations and anions, to produce a three‐dimensional supramolecular structure.

Nickel–quinolones interaction

“…1(C)) is a typical second-generation quinolone antimicrobial drug and is usually used for the treatment of infectious diseases in pets and livestock [13]. A thorough survey of the literature has revealed that a Ni(II) [14], two Zn(II) [15,16] and two out of three structurally characterized Cu(II) enrofloxacin complexes [17,18] have been reported by our lab.…”

Nickel–quinolones interaction. Part 4 — Structure and biological evaluation of nickel(II)–enrofloxacin complexes compared to zinc(II) analogues

“…From this point of view, diverse metal complexes of quinolones have been synthesized in an attempt to investigate the physicochemical properties and to evaluate their biological properties (antibacterial activity and DNA-binding properties) in comparison to the free quinolones [4]. A thorough survey of the literature has revealed that two Zn(II) [13,14] and two out of three structurally characterized Cu(II) enrofloxacin complexes [15,16] have been reported by our lab.…”

Structure, antimicrobial activity, DNA- and albumin-binding of manganese(II) complexes with the quinolone antimicrobial agents oxolinic acid and enrofloxacin

“…As the first fluoroquinolone developed for veterinary application, Herx is often used for the treatment of some urinary tract, respiratory tract and skin infectious diseases in pets and livestock [38]. Diverse mononuclear Ni(II) [13], Zn(II) [14,39], Cu(II) [40,41] and Fe(III) [42] as well dinuclear Cd(II), Pb(II) [43], La(III) and Sm(II) [11] enrofloxacinato complexes have been recently reported, most of them by our lab.…”