Nickel–quinolones interaction

Copper(II) complexes with antimicrobial drug flumequine: Structure and biological evaluation

“…The stock solution of CT DNA gave a ratio of UV absorbance at 260 and 280 nm (A 260 /A 280 ) in the range of 1.8-1.9, indicating that the DNA was sufficiently free of protein contamination. The DNA concentration was determined by the UV absorbance at 260 nm after 1:20 dilution using ε =6600 M − 1 cm − 1 [49][50][51][52].…”

“…Our recent studies have been focused on the study of divalent Co(II), Ni(II), Cu(II) or Zn(II) complexes with antimicrobial [10,[43][44][45][46][47][48][49][50] or antiinflammatory drugs [17,18,[51][52][53] in the absence or presence of N-donor(s) heterocyclic ligands. Taking into consideration the significance of the quinolones in medicine [1][2][3][4] and the fact that metal complexes with drugs may exhibit more pronounced biological properties in comparison to the free drugs, we have initiated the interaction of Cu(II) with quinolones [15,16,29,33,[36][37][38].…”

DNA(CT), protein(BSA) binding studies, anti-oxidant and cytotoxicity studies of new binuclear Ni(II) complexes containing 4(N)-substituted thiosemicarbazones

“…(Table 5) Moreover, from the results obtained for the four Ni(II) complexes, complex 3 showed the better activity may be due to the ethyl substitution in the terminal nitrogen of the ligand. From the above results, it can be concluded that the scavenging effects of the nickel salt, bis(diphenylphosphino)methane and free ligands is significantly less when compared to their corresponding Ni(II) complexes, which is mainly due to the chelation of the organic ligand with the Ni(II) ion [55,56]. …”

Two novel 2D waves copper(II) coordination polymer with the quinolone antimicrobial drugs ciprofloxacin: Synthesis, structure and biological evaluation

“…The UV spectra of a 2×10 (Table 4), suggesting that complex 2 has stronger intercalative binding ability to DNA than HCip and classical intercalator EB (K b =1.23(±0.07)×10 5 M − 1 ) [26][27][28].…”