A Controlled Trial of Bismuth Subsalicylate in Infants with Acute Watery Diarrheal Disease

Abstract

Treatment with bismuth subsalicylate decreases the duration of diarrhea and is a safe and effective adjunct to oral rehydration therapy for infants and young children with acute watery diarrhea.

Bismuth oxide aqueous colloidal nanoparticles inhibit Candida albicans growth and biofilm formation

“…8 In medicine, bismuth, in the form of bismuth subsalicylate, has been employed as an antidiarrheal to treat nauseas, vomiting, and stomach pain. 9 The chemistry of the binary oxides of bismuth is dominated by the +3 oxidation state. Most of the work on bismuth, concentrates on Bi 2 O 3 .…”

Towards a Structural Understanding of the Anti‐Ulcer and Anti‐Gastritis Drug Bismuth Subsalicylate

“…Thus, at the heart of the cluster in 1 is a central Bi 6 octahedron in which the six Bi atoms, Bi(6, 9, 13) and symmetry equivalents, are bound to only oxide atoms. Surrounding this are four further Bi 6 octahedra, which share edges with each of the four equatorial edges of the central Bi 6 , thus forming a planar cross of five octahedra. Above and below this plane are four further Bi 6 octahedra, joined at a single vertex (i.e.…”

“…The Bi 9 clusters comprise a central Bi 6 octahedron but with only seven of the eight trigonal faces capped by an O atom, as shown in Figure 2 a. The hole is covered by a m 3 -h 1 :h 1 :h 1 -salicylate: Bi (2,5,6) by O (16,17) and Bi (11,14,16) by O(61, 62). Three additional Bi atoms protrude from the core and are all connected through a bridging m 4 -O atom.…”

“…Salicylate ligands are bonded to all Bi atoms except Bi (6,19,13) [40] are attached to the Bi 38 cage. In addition, 16 acetone ligands are coordinated to the cage, four of which bridge two bismuth atoms unsymmetrically (0.13, 0.17 ).…”

Oral Transforming Growth Factor-α Enhances Jejunal Mucosal Recovery and Electrical Resistance in Piglet Rotavirus Enteritis

“…TGFa treatment for 12 d also produced a 30-50% increase in jejunal mucosal mass (protein content and wet weight), compared with the corresponding values in salinetreated piglets and in uninfected controls. However, oral TGFa did not hasten the resolution of diarrhea, enhance the specific For treatment of infants with severe acute diarrhea, only fiber-containing formulas, smectite (a mineral clay), and bismuth subsalicylate have been shown to improve stool consistency and reduce the duration of diarrhea (1)(2)(3)(4). However, no treatment has been demonstrated to facilitate mucosal recovery in infants with acute intestinal damage.…”