Towards a Structural Understanding of the Anti‐Ulcer and Anti‐Gastritis Drug Bismuth Subsalicylate

Clean and Efficient Synthesis Using Mechanochemistry: Coordination Polymers, Metal-Organic Frameworks and Metallodrugs

“…The structure of bismuth disalicylate hydrate is currently the only known crystal structure for a bismuth salicylate complex without auxiliary organic ligands. As a potential model for the bismuth subsalicylate active drug ingredient, it is in striking contrast to previously proposed 81 model discrete oxo-cluster structures involving additional acetone ligands, which were obtained by hydrolysis of bismuth salicylate in acetone solution. Recrystallization of bismuth disalicylate hydrate from a DMF solution, however, leads to the formation of analogous clusters but decorated with DMF ligands (Figure 10c).…”

“…These include the recent reports on the gas carbon dioxide uptake by mechanochemical treatment of metal-organic silver(I)-phosphine complexes, 82 as well as on the reversible mechanochromism and mechanoluminescence in metalorganic materials. 83,84 In particular, Bowmaker and co-workers 81 have reported that manual grinding of solid silver carbonate, Ag 2 CO 3 with triphenylphosphine (PPh 3 ) in air and in the presence of liquid ethanol leads to the absorption of one equivalent of water (present in the form of air moisture) and one equivalent of CO 2 gas to yield bis(triphenylphosphino)silver(I) hydrogencar-bonate (CCDC code OTAHUN) which can again release CO 2 upon thermal treatment. Monitoring of the reaction through solid-state infrared spectroscopy suggests a two-step mechanism involving the formation of the solid tetrakis(triphenylphosphino)silver(I) carbonate as the intermediate ( Figure 11).…”

Synthesis and structural studies of the simplest bismuth(iii) oxo-salicylate complex: [Bi4(μ3-O)2(HO-2-C6H4CO2)8]·2Solv (Solv = MeCN or MeNO2)

“…Subsequent hydrolysis of these compounds by dissolution in wet solvents leads to a variety of bismuth-oxo alkoxides and carboxylates. 7,20 Recently, Friščić et. al.…”

Arylstibonic acids [H8(RSb)12O28]; precursors to organometallic isopolyoxostibonates [Na2H9(RSb)12O30]−, (R = aryl)

“…Main group elements, including As and Sb, have been incorporated into the framework to give hetero-POMs [6]. However there are very few previous reports of iso-POMs from the p-block elements [7].…”