A Continuously Active Antimicrobial Coating effective against Human Coronavirus 229E

Ikner, Luisa A.; Torrey, Jason R.; Gundy, Patricia M.; Gerba, Charles P.

doi:10.1101/2020.05.10.20097329

Cited by 12 publications

(14 citation statements)

References 11 publications

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“…The risk of acquiring a SARS-CoV-2 infection indirectly, through transfer of virus from a contaminated HITES to a susceptible mucous membrane through the intermediacy of the hands, therefore may remain for weeks after the initial surface contamination event. The requirement for frequent sanitization of HITES is driven by the possibility for recontamination of these environmental surfaces by infected persons 52 . Infectivity data addressing the frequency of recontamination of HITES with SARS-CoV-2 have not yet appeared in the literature, to our knowledge.…”

Section: Discussionmentioning

confidence: 99%

Microbicidal actives with virucidal efficacy against SARS-CoV-2 and other beta- and alpha-coronaviruses and implications for future emerging coronaviruses and other enveloped viruses

Ijaz

Nims

Zhou³

et al. 2021

Sci Rep

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Mitigating the risk of acquiring coronaviruses including SARS-CoV-2 requires awareness of the survival of virus on high-touch environmental surfaces (HITES) and skin, and frequent use of targeted microbicides with demonstrated efficacy. The data on stability of infectious SARS-CoV-2 on surfaces and in suspension have been put into perspective, as these inform the need for hygiene. We evaluated the efficacies of formulated microbicidal actives against alpha- and beta-coronaviruses, including SARS-CoV-2. The coronaviruses SARS-CoV, SARS-CoV-2, human coronavirus 229E, murine hepatitis virus-1, or MERS-CoV were deposited on prototypic HITES or spiked into liquid matrices along with organic soil loads. Alcohol-, quaternary ammonium compound-, hydrochloric acid-, organic acid-, p-chloro-m-xylenol-, and sodium hypochlorite-based microbicidal formulations were evaluated per ASTM International and EN standard methodologies. All evaluated formulated microbicides inactivated SARS-CoV-2 and other coronaviruses in suspension or on prototypic HITES. Virucidal efficacies (≥ 3 to ≥ 6 log10 reduction) were displayed within 30 s to 5 min. The virucidal efficacy of a variety of commercially available formulated microbicides against SARS-CoV-2 and other coronaviruses was confirmed. These microbicides should be useful for targeted surface and hand hygiene and disinfection of liquids, as part of infection prevention and control for SARS-CoV-2 and emerging mutational variants, and other emerging enveloped viruses.

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Section: Discussionmentioning

confidence: 99%

Microbicidal actives with virucidal efficacy against SARS-CoV-2 and other beta- and alpha-coronaviruses and implications for future emerging coronaviruses and other enveloped viruses

Ijaz

Nims

Zhou³

et al. 2021

Sci Rep

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“…The spray coating technique is a versatile and inexpensive approach that is the most common strategy used by the governments for disinfection and protection of public surfaces, 104 for example, antimicrobial coated surfaces with SurfaceWise2™ (a quaternary ammonium polymer coating) prepared and tested against human coronavirus. 105 The results of the developed antiviral surface coating showed the effectiveness of the spray coating technique to reduce the concentration of the viruses by greater than 90% in 10 min and greater than 99.9% after 2 h of contact. The coating formulation when tested in suspension yielded a greater than 99.99% reduction of HCoV 229E within 10 min of contact.…”

Section: Antiviral Coatings Against Sars-cov-2mentioning

confidence: 95%

Fight against COVID-19: The case of antiviral surfaces

et al. 2021

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The COVID-19 pandemic is the largest global public health outbreak in the 21st century so far. Based on World Health Organization reports, the main source of SARS-CoV-2 infection is transmission of droplets released when an infected person coughs, sneezes, or exhales. Viral particles can remain in the air and on the surfaces for a long time. These droplets are too heavy to float in air and rapidly fall down onto the surfaces. To minimize the risk of the infection, entire surrounding environment should be disinfected or neutralized regularly. Development of the antiviral coating for the surface of objects that are frequently used by the public could be a practical route to prevent the spread of the viral particles and inactivation of the transmission of the viruses. In this short review, the design of the antiviral coating to combat the spread of different viruses has been discussed and the technological attempts for minimizing the coronavirus outbreak have been highlighted.

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“…The outcome of this study yields an opportunity toward controlling the COVID-19 transmission from contaminated fomites. 109 However, more studies are needed to further evaluate the effectiveness of the proposed antiviral coating.…”

Section: Synthetic Antimicrobial Polymersmentioning

confidence: 99%

Antibacterial and Antiviral Functional Materials: Chemistry and Biological Activity toward Tackling COVID-19-like Pandemics

Balasubramaniam

Prateek

Ranjan

et al. 2020

ACS Pharmacol. Transl. Sci.

188

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The ongoing worldwide pandemic due to COVID-19 has created awareness toward ensuring best practices to avoid the spread of microorganisms. In this regard, the research on creating a surface which destroys or inhibits the adherence of microbial/viral entities has gained renewed interest. Although many research reports are available on the antibacterial materials or coatings, there is a relatively small amount of data available on the use of antiviral materials. However, with more research geared toward this area, new information is being added to the literature every day. The combination of antibacterial and antiviral chemical entities represents a potentially path-breaking intervention to mitigate the spread of disease-causing agents. In this review, we have surveyed antibacterial and antiviral materials of various classes such as small-molecule organics, synthetic and biodegradable polymers, silver, TiO2, and copper-derived chemicals. The surface protection mechanisms of the materials against the pathogen colonies are discussed in detail, which highlights the key differences that could determine the parameters that would govern the future development of advanced antibacterial and antiviral materials and surfaces.

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A Continuously Active Antimicrobial Coating effective against Human Coronavirus 229E

Cited by 12 publications

References 11 publications

Microbicidal actives with virucidal efficacy against SARS-CoV-2 and other beta- and alpha-coronaviruses and implications for future emerging coronaviruses and other enveloped viruses

Microbicidal actives with virucidal efficacy against SARS-CoV-2 and other beta- and alpha-coronaviruses and implications for future emerging coronaviruses and other enveloped viruses

Fight against COVID-19: The case of antiviral surfaces

Antibacterial and Antiviral Functional Materials: Chemistry and Biological Activity toward Tackling COVID-19-like Pandemics

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