A conductive cell-delivery construct as a bioengineered patch that can improve electrical propagation and synchronize cardiomyocyte contraction for heart repair

Chen, Shanglin; Hsieh, Meng-Hsuan; Li, Shuhong; Wu, Jun; Weisel, Richard D.; Chang, Yen; Sung, Hsing‐Wen; Li, Ren‐Ke

doi:10.1016/j.jconrel.2020.01.027

Cited by 56 publications

(46 citation statements)

References 38 publications

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“…The electric pulse propagated twice as fast as compared to when MI heart was injected with gelatin alone. A cell-laden conductive patch also led to improved tissue regeneration with reduced scar size and shorter QRS intervals [95]. Table 4 shows the in vivo cardiac repair efficacy of the conductive scaffolds.…”

Section: Conductive Substrates For In Vivo Cardiac Repairmentioning

confidence: 97%

“…In this way, PG could be stimulated and electrically synchronised to AG under the influence of action potentials generated by the active group, as shown in Figure 3. Recent studies have confirmed that the conductive scaffold can decrease the resistivity of the fibrotic scar tissue in the infarcted region [25,[93][94][95]. In one of the studies, the Langendorff-perfused beating heart as the source of ionic current was placed on one side and a microelectrode array (MEA) was placed on the other side to measure the field potential amplitude, with a gelatin matrix cushion in the middle mimicking the inert scar tissue.…”

Section: The Underlying Mechanisms Of the Positive Role Of Conductive Substrates In Cardiac Tissue Engineeringmentioning

confidence: 99%

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Intrinsically Conductive Polymers for Striated Cardiac Muscle Repair

Haq

Carotenuto

et al. 2021

IJMS

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One of the most important features of striated cardiac muscle is the excitability that turns on the excitation-contraction coupling cycle, resulting in the heart blood pumping function. The function of the heart pump may be impaired by events such as myocardial infarction, the consequence of coronary artery thrombosis due to blood clots or plaques. This results in the death of billions of cardiomyocytes, the formation of scar tissue, and consequently impaired contractility. A whole heart transplant remains the gold standard so far and the current pharmacological approaches tend to stop further myocardium deterioration, but this is not a long-term solution. Electrically conductive, scaffold-based cardiac tissue engineering provides a promising solution to repair the injured myocardium. The non-conductive component of the scaffold provides a biocompatible microenvironment to the cultured cells while the conductive component improves intercellular coupling as well as electrical signal propagation through the scar tissue when implanted at the infarcted site. The in vivo electrical coupling of the cells leads to a better regeneration of the infarcted myocardium, reducing arrhythmias, QRS/QT intervals, and scar size and promoting cardiac cell maturation. This review presents the emerging applications of intrinsically conductive polymers in cardiac tissue engineering to repair post-ischemic myocardial insult.

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Section: Conductive Substrates For In Vivo Cardiac Repairmentioning

confidence: 97%

Section: The Underlying Mechanisms Of the Positive Role Of Conductive Substrates In Cardiac Tissue Engineeringmentioning

confidence: 99%

Intrinsically Conductive Polymers for Striated Cardiac Muscle Repair

Haq

Carotenuto

et al. 2021

IJMS

View full text Add to dashboard Cite

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“…[ 18 ] Self‐doped conductive polymer (poly‐3‐amino‐4‐ methoxybenzoic acid, PAMB) had 30 times higher conductivity compared with gelatin‐based Gelfoam (a commercial product). [ 95 ] As a result, the PAMB epicardial patch significantly increased electrical impulse propagation and synchronic cardiomyocyte contraction across the scar region. Mawad et al.…”

Section: Cardiac Bioelectronic Interfacementioning

confidence: 99%

Conjugated Polymer for Implantable Electronics toward Clinical Application

Liu

Feig

Bao

2021

Adv Healthcare Materials

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Owing to their excellent mechanical flexibility, mixed‐conducting electrical property, and extraordinary chemical turnability, conjugated polymers have been demonstrated to be an ideal bioelectronic interface to deliver therapeutic effect in many different chronic diseases. This review article summarizes the latest advances in implantable electronics using conjugated polymers as electroactive materials and identifies remaining challenges and opportunities for developing electronic medicine. Examples of conjugated polymer‐based bioelectronic devices are selectively reviewed in human clinical studies or animal studies with the potential for clinical adoption. The unique properties of conjugated polymers are highlighted and exemplified as potential solutions to address the specific challenges in electronic medicine.

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“…[ 24,25 ] As a result of their biocompatibility and intrinsic antioxidative and antibacterial properties, CPs have been extensively used in many biomedical applications, including wound healing dressings. [ 16,26–29 ] Among various known CPs, polyaniline (PANI), polypyrrole (PPy), and poly(3,4‐ethylenedioxythiophene) (PEDOT) are the most studied for the healing of wounds, owing to their excellent electro‐optical properties, easy availability, and versatile doping chemistry. [ 16 ] Figure displays the chemical structures of PANI, PPy, and PEDOT.…”

Section: Electroactive Wound Dressings That Incorporate Cpsmentioning

confidence: 99%

Conductive Materials for Healing Wounds: Their Incorporation in Electroactive Wound Dressings, Characterization, and Perspectives

Korupalli

Nguyen

et al. 2020

Adv Healthcare Materials

Self Cite

109

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The use of conductive materials to promote the activity of electrically responsive cells is an effective means of accelerating wound healing. This article focuses on recent advancements in conductive materials, with emphasis on overviewing their incorporation with non‐conducting polymers to fabricate electroactive wound dressings. The characteristics of these electroactive dressings are deliberated, and the mechanisms on how they accelerate the wound healing process are discussed. Potential directions for the future development of electroactive wound dressings and their potential in monitoring the course of wound healing in vivo concomitantly are also proposed.

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A conductive cell-delivery construct as a bioengineered patch that can improve electrical propagation and synchronize cardiomyocyte contraction for heart repair

Cited by 56 publications

References 38 publications

Intrinsically Conductive Polymers for Striated Cardiac Muscle Repair

Intrinsically Conductive Polymers for Striated Cardiac Muscle Repair

Conjugated Polymer for Implantable Electronics toward Clinical Application

Conductive Materials for Healing Wounds: Their Incorporation in Electroactive Wound Dressings, Characterization, and Perspectives

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