A comprehensive review on secondary metabolites and health-promoting effects of edible lichen

Zhao, Yingshu; Wang, Mingfu; Xu, Baojun

doi:10.1016/j.jff.2020.104283

Cited by 60 publications

(42 citation statements)

References 98 publications

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“…Taking into consideration that a large number of lichenochemicals are organic polycyclic compounds of phenolic nature, [16] we determined the TPC of lichen species under investigation ( Figure 1). Besides this, it is claimed that a significant number of lichen species have been ethnomedically used for treating blood‐related issues [4,17] . Based on these premises, it might be reasonable to expect an interaction between lichenochemicals and blood coagulation.…”

Section: Discussionmentioning

confidence: 99%

New Insights into the Biological Activity of Lichens: Bioavailable Secondary Metabolites of Umbilicaria decussata as Potential Anticoagulants

Vaez

Davarpanah

2021

Chemistry & Biodiversity

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This study reports the in vitro anticoagulation activity of acetonic extract (AE) of 42 lichen species and the identification of potential bioavailable anticoagulant compounds from Umbilicaria decussata as a competent anticoagulant lichen species. Lichens’ AEs were evaluated for their anticoagulant activity by monitoring activated partial thromboplastin time (APTT) and prothrombin time (PT) assays. A strong, positive correlation was observed between total phenolics concentration (TPC) of species and blood coagulation parameters. U. decussata was the only species with the longest clotting time in both APTT and PT assays. The research was moved forward by performing in vivo assays using rats. The results corroborated the dose‐dependent impact of U. decussata’s AE on rats’ clotting time. Major secondary metabolites of U. decussata and their plasma‐related bioavailability were also investigated using LC‐ESI‐MS/MS. Atranol, orsellinic acid, D‐mannitol, lecanoric acid, and evernic acid were detected as possible bioavailable anticoagulants of U. decussata. Our findings suggest that U. decussata might be a potential anticoagulant lichen species that can be used for the prevention or treatment of coagulation‐related issues such as cardiovascular diseases (CVDs).

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Section: Discussionmentioning

confidence: 99%

New Insights into the Biological Activity of Lichens: Bioavailable Secondary Metabolites of Umbilicaria decussata as Potential Anticoagulants

Vaez

Davarpanah

2021

Chemistry & Biodiversity

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“…Lichens are rich in mineral elements, and good protein sources (5.95–16.2%). The literature data showed the presence of isoleucine, leucine, methionine, phenylalanine, threonine, tryptophan and valine as a result of the amino acid content in lichen thalli Rimelia reticulate from Africa [ 4 ]. For example, during the war in the territory of Bośnia and Hercegovina, fungi and also lichens were used by humans for food due to poor survival conditions [ 56 ].…”

Section: Nutritional Value Of Edible Mushrooms Lichens and Algaementioning

confidence: 99%

“…The growing interest in fungi, including lichen-forming fungi, in recent decades has been associated with the isolation of many bioactive substances in fungi, especially macrofungi, and the documentation of their health-promoting properties [ 4 , 58 , 63 , 64 ]. Antioxidants are of particular interest to researchers due to their ability to remove free radicals generated in the human body.…”

Section: Bioactive Compounds Of Fungi and Their Health-promoting Propertiesmentioning

confidence: 99%

“…About 700 species of fungi have been found to have therapeutic properties [ 1 ], so they may be a good source of biologically active compounds for use in the pharmaceutical industry. Many species of edible mushrooms, lichens and algae are a source of compounds with dietary and medicinal properties, exhibiting anticancer, immunostimulatory (glucans, glycoproteins, sesquiterpenoids, triterpenoids), anti-atherosclerosis (chitin, chitosans, statins), antibacterial and antifungal (antibiotic) as well as antioxidant (sterols, tocopherols, flavonoids, carotenoids, indole compounds and phenolic compounds) properties [ 2 , 3 , 4 , 5 , 6 ]. The healing and antioxidant effect of edible mushrooms, lichens and algae complements their nutritional value.…”

Section: Introductionmentioning

confidence: 99%

“…Most of them are characteristic only to lichen-forming fungi [ 18 ]. Lichen secondary metabolites, including amino acid derivatives, sugar alcohols, aliphatic acids, macrolytic lactones, monocyclic aromatic compounds, quinines, chromones, xanthones, dibenzofurans, depsides, depsidones, depsones, terpenoids, steroids, carotenoids, and diphenyl ethers indicate the great potential of lichens for pharmaceutical purposes [ 4 , 15 , 17 , 18 ]. Unlike medical mushrooms, their slow growth is a problem of the production of these substances in cultures [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Fungi and Algae as Sources of Medicinal and Other Biologically Active Compounds: A Review

2021

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Many species of fungi including lichenized fungi (lichens) and algae have the ability to biosynthesize biologically active compounds. They produce, among others, polysaccharides with anticancer and immunostimulatory properties: (1) Background: This paper presents the characteristics of the most important bioactive compounds produced by fungi and algae; (2) Methods: Based on the example of the selected species of mushrooms, lichens and algae, the therapeutic properties of the secondary metabolites that they produce and the possibilities of their use are presented; (3) Results: The importance of fungi, especially large-fruited mushrooms, lichens and algae, in nature and human life is discussed, in particular, with regard to their use in the pharmaceutical industry and their nutritional value; (4) Conclusions: The natural organisms, such as fungi, lichenized fungi and algae, could be used as supplementary medicine, in the form of pharmaceutical preparations and food sources. Further advanced studies are required on the pharmacological properties and bioactive compounds of these organisms.

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Overview of Lichen

Das,

Sarkar,

Devi

2024

Chemistry, Biology and Pharmacology of Lichen

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A comprehensive review on secondary metabolites and health-promoting effects of edible lichen

Cited by 60 publications

References 98 publications

New Insights into the Biological Activity of Lichens: Bioavailable Secondary Metabolites of Umbilicaria decussata as Potential Anticoagulants

New Insights into the Biological Activity of Lichens: Bioavailable Secondary Metabolites of Umbilicaria decussata as Potential Anticoagulants

Fungi and Algae as Sources of Medicinal and Other Biologically Active Compounds: A Review

Overview of Lichen

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