A comparison of the prognoses for deep and subcutaneous sarcomas of the extremities.

Peabody, Terrance D.; Monson, David K.; Montag, Anthony; Schell, Michael J.; Finn, Henry A.; Simon, Michael A.

doi:10.2106/00004623-199408000-00007

Cited by 65 publications

(52 citation statements)

References 23 publications

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“…The importance of increasing tumor size as an adverse prognostic factor is in line with earlier studies on soft tissue LMS and other histopathologic sarcoma types. 8,10,[11][12][13]18,[29][30][31]39,40,41 Histologic malignancy grade is considered to be the most important prognostic factor in adult soft tis- sue sarcomas. Our multivariate analysis showed that histopathologic malignancy grade is a significant prognostic factor for metastatic disease and death.…”

Section: Discussionmentioning

confidence: 99%

Clinical course of nonvisceral soft tissue leiomyosarcoma in 225 patients from the Scandinavian Sarcoma Group

Svarvar¹,

Böhling²,

Berlin³

et al. 2007

Cancer

127

133

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BACKGROUND.Leiomyosarcoma of nonvisceral soft tissues is an uncommon malignant tumor; thus, only small numbers of cases have been reported. This study was based on a large series of patients from the Scandinavian Sarcoma Group Register acquired during a 15‐year period (from 1986 to 2001). Follow‐up information was available for all patients.METHODS.The authors analyzed the clinical features of 225 patients with cutaneous, subcutaneous, or deep‐seated leiomyosarcoma of the extremities, trunk wall, and superficial parts of the head and neck region to determine the natural course of the disease. Only patients who received their treatment at a specialist sarcoma center were included. Re‐evaluation of histopathology was performed.RESULTS.The age of the patients (121 women and 104 men) ranged from 20 years to 98 years (median, 70 years), and the tumors ranged in size from 0.6 cm to 35 cm (median, 4.0 cm). Eighty‐two percent of the tumors were classified as high grade. The median follow‐up for survivors was 5.5 years. The local treatment was adequate in 154 of 206 patients (75%) who were without metastasis at presentation. At 10 years, 84% of the 206 patients with localized disease at presentation were free from local recurrence, 66% remained metastasis free, and 49% were alive. Multivariate analysis showed that higher malignancy grade (P = .006), larger tumor size (P = .003), and deeper tumor location (P = .002) were correlated significantly with decreased metastasis‐free survival, inadequate local treatment was correlated with local recurrence (P = .007), and high malignancy grade was correlated with decreased overall survival (P = .007).CONCLUSIONS.The long‐term prognosis for patients with subcutaneous and deep‐seated soft tissue leiomyosarcoma remains poor despite the ability to achieve adequate local control through nonmutilating surgery with or without radiotherapy. Cancer 2007. © 2006 American Cancer Society.

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Section: Discussionmentioning

confidence: 99%

Clinical course of nonvisceral soft tissue leiomyosarcoma in 225 patients from the Scandinavian Sarcoma Group

Svarvar¹,

Böhling²,

Berlin³

et al. 2007

Cancer

127

133

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“…Our initial evaluation consisted of a physical examination, a pre-operative extremity MRI scan, a computed tomography (CT) scan of the chest and abdomen to determine the presence of metastases, and a review of the outside pathologic material with the musculoskeletal pathologist [17,18]. After a multidisciplinary meeting with radiation and medical oncologists, a treatment plan for each patient was formulated with wide excision, adjuvant chemotherapy and radiotherapy, and soft-tissue reconstruction.…”

Section: Discussionmentioning

confidence: 99%

Outcomes of re-excision after unplanned excisions of soft-tissue sarcomas

et al. 2005

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“…However, there is a close correlation between tumor size, localization and depth; proximal and deep-seated tumors are larger. In most studies, size seems to be the relevant factor (Gustafson 1994, Peabody et al 1994; together with histologic malignancy grade, size seems to be the strongest prognosticator. Nevertheless, Coindre et al (1996) and Pisters et al (1996) in a large series reported that both tumor size and tumor depth were of independent prognostic importance.…”

Section: Patient Characteristics Tumor Localization and Sizementioning

confidence: 99%