Prognostic factors in soft tissue sarcoma

Rydholm, Anders; Gustafson, Pelle; Alvegård, Thor; Sæter, Gunnar; Blomqvist, Carl

doi:10.1080/17453674.1999.11744824

Cited by 13 publications

(15 citation statements)

References 62 publications

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“…Soft tissue sarcomas comprise a group of rare neoplasms, usually with poor prognosis. [42][43][44][45] Because the prognostication system of these tumors, due to their tremendous histological heterogeneity and ambiguities in grading, 46 remains imperfect, 45 there is a need for the search of new markers useful in predicting the clinical outcomes of patients with soft tissue sarcomas. To the best of our knowledge this is the first paper in which a wide cytokine serum profile in soft tissue sarcomas patients was analyzed for its clinical significance.…”

Section: Cytokine Serum Levels During Follow-upmentioning

confidence: 99%

Cytokine serum levels in soft tissue sarcoma patients: Correlations with clinico‐pathological features and prognosis

Rutkowski

Kamińska

Kowalska

et al. 2002

Intl Journal of Cancer

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We investigated the correlations between serum levels of selected proinflammatory, hematopoietic and angiogenic cytokines and soluble cytokine receptors with the clinicopathological features and prognosis in soft tissue sarcoma patients. Serum levels of 9 cytokines (TNF␣, IL-1ra, IL-6, IL-8, IL-10, M-CSF, G-CSF, VEGF, bFGF) and 4 free cytokine receptors (sIL-2R␣, sIL-6R, TNFRI, TNFRII) were measured by means of an enzyme-linked immunoadsorbent assay kit in 156 soft tissue sarcoma patients before the treatment and in 50 healthy controls. Serum levels of 10 cytokines and cytokine receptors were also assayed during patients' follow-up after the treatment. Significantly elevated pretreatment serum levels of 11/13 cytokines and cytokine receptors were found in sarcoma patients, as compared to healthy controls.

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Section: Cytokine Serum Levels During Follow-upmentioning

confidence: 99%

Cytokine serum levels in soft tissue sarcoma patients: Correlations with clinico‐pathological features and prognosis

Rutkowski

Kamińska

Kowalska

et al. 2002

Intl Journal of Cancer

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“…Os resultados do tratamento dos pacientes com STM têm mostrado pouco avanço nos últimos anos e a indicação do uso da quimioterapia adjuvante é controversa (3)(4)(5) . Estudos iniciais mostraram melhora na sobrevida global e na sobrevida livre de doença, mas trabalhos subseqüentes não conseguiram comprovar o benefício da quimioterapia (10)(11) .…”

Section: Discussionunclassified

“…O tempo de seguimento foi também suficiente para detectar a ocorrência de metástases, já que a maioria destas ocorre nos dois primeiros anos de seguimento (13)(14) . A disseminação metastática foi observada em 40% dos casos, compatível com a literatura, que mostra incidência de metástases variando de 26,1% a 56,1% (2)(3)(4)(5)13,15) . Os fatores determinantes foram o tamanho maior do que 10cm, a localização extracompartimental, o alto grau de malignidade histológica e a presença de necrose e invasão vascular detectadas pela histologia.…”

Section: Discussionunclassified

“…A necessidade do tratamento quimioterápico adjuvante não é consenso na literatura e sua indicação depende de vários fatores prognósticos. A combinação desses fatores cria sistemas de estadiamento que pretendem separar os pacientes de acordo com a expectativa de evolução da doença (4) . Vários fatores têm sido associados com o prognós-tico nos STM, como idade, sexo, localização, profundidade, tamanho, tipo histológico, grau de malignidade histológica, necrose tumoral, invasão vascular à microscopia e aneuploidias.…”

Section: Introductionunclassified

“…Vários fatores têm sido associados com o prognós-tico nos STM, como idade, sexo, localização, profundidade, tamanho, tipo histológico, grau de malignidade histológica, necrose tumoral, invasão vascular à microscopia e aneuploidias. Alguns desses fatores são consensuais, enquanto outros não têm mostrado resultados consistentes (3)(4)(5)(6)(7)(8) . Dentre esses fatores, os mais associados ao desenvolvimento de metástases são o alto grau de malignidade histológica, o tamanho inicial do tumor, a profundidade em relação à fáscia muscular e a presença de necrose e invasão vascular detectadas pela histologia (4)(5)(6)(7) .…”

Section: Introductionunclassified

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Fatores prognósticos para o desenvolvimento de metástases nos sarcomas de tecidos moles

Teixeira¹,

Araújo²,

Andrade³

et al. 2008

Rev. bras. ortop.

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10cm (p = 0,007), com o alto grau de malignidade (p = 0,007), com a presença de necrose (p = 0,002) e com a presença de invasão vascular (p = 0,034). A idade (p = 1,000), o sexo (0,709), a localização em segmentos corporais (p = 0,298), a profundidade (p = 0,288), a margem cirúrgica (p = 0,419) e a manipulação prévia do tumor (p = 1,000) não apresentaram correlação com a ocorrência de metástases a distância. Na análise multivariada apenas a localização extracompartimental (p = 0,008), o tamanho (p = 0,018) e a presença de invasão vascular (p = 0,043) foram significativos. CONCLUSÃO: O desenvolvimento de metástases a distância nos pacientes com sarcoma de tecidos moles depende da localização extracompartimental, do tamanho (> 10cm), do alto grau de malignidade histológica, da presença de necrose e da invasão vascular à histologia.]]>

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Benefit of Surgical Treatment of Lung Metastasis in Soft Tissue Sarcoma

Rehders

Hosch²,

Scheunemann³

et al. 2007

Arch Surg

104

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Interventions: Sternotomy or anterior lateral thoracotomy was performed for metastasectomy, including wedge resection or lobectomy.Main Outcome Measure: The effects of clinical and pathologic factors on disease-specific survival were analyzed using the log rank test and a multivariate Cox proportional hazards model.Results: Primary tumor size was pT1 in 13 patients and pT2 in 48 patients. The differentiation was high in 7 patients, intermediate in 19 patients, and low in 35 patients. The mean number of resected pulmonary metastatic lesions was 5 (range, 1-48). An anterolateral thoracotomy was performed in 39 patients, and sternotomy in 22 patients. There were no significant postoperative complications that required surgical revision. The perioperative mortality was 0%. At a mean follow-up of 60 months, the mean survival time after metastasectomy was 33 months (range, 2-125 months). The 5-year survival was 25%. The number of resected lung metastatic lesions had no prognostic relevance (P=.37). Conclusions:Patients with lung metastasis from soft tissue sarcomas benefit from surgical excision. This treatment has low complication rates and has a favorable influence on the course of the disease. Long-term survival is possible even when recurrent pulmonary disease is resected.

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Prognostic factors in soft tissue sarcoma

Cited by 13 publications

References 62 publications

Cytokine serum levels in soft tissue sarcoma patients: Correlations with clinico‐pathological features and prognosis

Cytokine serum levels in soft tissue sarcoma patients: Correlations with clinico‐pathological features and prognosis

Fatores prognósticos para o desenvolvimento de metástases nos sarcomas de tecidos moles

Benefit of Surgical Treatment of Lung Metastasis in Soft Tissue Sarcoma

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