Clinical course of nonvisceral soft tissue leiomyosarcoma in 225 patients from the Scandinavian Sarcoma Group

Abstract

BACKGROUND.Leiomyosarcoma of nonvisceral soft tissues is an uncommon malignant tumor; thus, only small numbers of cases have been reported. This study was based on a large series of patients from the Scandinavian Sarcoma Group Register acquired during a 15‐year period (from 1986 to 2001). Follow‐up information was available for all patients.METHODS.The authors analyzed the clinical features of 225 patients with cutaneous, subcutaneous, or deep‐seated leiomyosarcoma of the extremities, trunk wall, and superficial parts of the head and neck region to determine the natural course of the disease. Only patients who received their treatment at a specialist sarcoma center were included. Re‐evaluation of histopathology was performed.RESULTS.The age of the patients (121 women and 104 men) ranged from 20 years to 98 years (median, 70 years), and the tumors ranged in size from 0.6 cm to 35 cm (median, 4.0 cm). Eighty‐two percent of the tumors were classified as high grade. The median follow‐up for survivors was 5.5 years. The local treatment was adequate in 154 of 206 patients (75%) who were without metastasis at presentation. At 10 years, 84% of the 206 patients with localized disease at presentation were free from local recurrence, 66% remained metastasis free, and 49% were alive. Multivariate analysis showed that higher malignancy grade (P = .006), larger tumor size (P = .003), and deeper tumor location (P = .002) were correlated significantly with decreased metastasis‐free survival, inadequate local treatment was correlated with local recurrence (P = .007), and high malignancy grade was correlated with decreased overall survival (P = .007).CONCLUSIONS.The long‐term prognosis for patients with subcutaneous and deep‐seated soft tissue leiomyosarcoma remains poor despite the ability to achieve adequate local control through nonmutilating surgery with or without radiotherapy. Cancer 2007. © 2006 American Cancer Society.

Smooth muscle tumors of soft tissue and non-uterine viscera: biology and prognosis

“…There has been sometimes a quest for more accurate prediction (eg, plotting mitotic rate with recurrences/ metastases), but very small sample size in most series of soft tissue leiomyosarcomas has hampered The largest recent series from the Scandinavian Sarcoma Group showed a metastatic rate of 20% for subcutaneous and 60% for deep intramuscular leiomyosarcomas. 42 Tumors with lower mitotic rates may show longer recurrence-free survivals. Disruption of tumor (previous partial surgery) was found an adverse factor in one series.…”

Leiomyosarcoma of vascular origin: case report

“…Vascular LMS is a rare tumor origin the media of vessel walls, low extremities veins are the most commonly veins affected, furthermore, the popliteal and tibial veins even less frequently, some few cases have been published [1,[4][5][6] . The diagnostic of leiomyosarcoma, it must first be distinguished from other types of tumors, that differentiate these tumors from other soft tissue sarcomas it's not easy to do, a good histological and immunohistochemical study using markers are useful for the diagnosis.…”

“…Dzsinich et al (1992) [5] reported on 13 cases of vascular LMS, which 8/13 arose from the inferior cava vein 2/13 from the iliac vein, and 2/13 cases from the saphenous vein. Svarvar et al (2007) [6] reported on 225 patients with LMS of all types from the Scandinavian Sarcoma Group with a cumulative survival of 49% at 10 years. The tumours in Berlin's series (1984) [8] were located in the superficial femoral vein in 3 patients, in the great saphenous vein in one case, in the popliteal vein in one case, and in the axillary vein in one case.…”

“…Local [1,2] . It discus follow-up, and to three types a on, followed by LMS are a rare enous or arteria ors that origina ds to the femora MS could be c needs histolog or biopsy [5][6][7] . T cepted.…”

“…The CT show , it displaced th Figure 1). T ed a polypoida sistency, light emorrhagic foc mposed of diff Figure 3A, 3B itotic figures w chemistry reve in (SMA [4][5][6] . A correc hy [4] .…”