A Comparison of the Antifungal Activity of Herbal Toothpastes against Other Brands of Toothpastes on Clinical Isolates of&lt;i&gt; Candida albicans&lt;/i&gt; and &lt;i&gt;Candida dubliniensis&lt;/i&gt;

Salameh

Asian Pacific Journal of Tropical Biomedicine

et al. 2012

In the present study, it has been demonstrated that toothpaste containing both herbal extracts and sodium fluoride as active ingredients are more effective in control of C. albicans, while toothpaste that containing monofluorophosphate as an active ingredient is less effective against C. albicans. Some herbal toothpaste formulations studied in our experiments, appear to be equally effective as the fluoride dental formulations and it can be used as an alternative to conventional formulations for individuals who have an interest in naturally-based products. Our results may provide invaluable information for dental professionals.

Section: Discussionsupporting

confidence: 94%

“…Most studies on antimicrobial activity of dentifrices have been focused on their potential to inhibit bacterial growth. In particular, little information was found in recent literature research concerning their antifungal potentials [2,12] .…”

Section: Discussionmentioning

confidence: 99%

Assessment of antifungal activity of herbal and conventional toothpastes against clinical isolates of Candida albicans

Salameh

Asian Pacific Journal of Tropical Biomedicine

et al. 2012

“…A range of dentifrices, including Parodontax, were previously assessed for antimicrobial potency against Candida albicans using a simple well diffusion assay (33). Antifungal effects were reported for certain herbal dentifrices that were approximately equivalent to those containing fluoride, although comparators formulated with antimicrobial active ingredients were not included (33).…”

Section: Discussionmentioning

confidence: 99%

“…Antifungal effects were reported for certain herbal dentifrices that were approximately equivalent to those containing fluoride, although comparators formulated with antimicrobial active ingredients were not included (33). A similar assessment of 14 herbal formulations reported modest and variable effects against four bacterial species.…”

Section: Discussionmentioning

confidence: 99%

Bacteriological Effects of Dentifrices with and without Active Ingredients of Natural Origin

Ledder

Latimer

Humphreys

et al. 2014

Appl Environ Microbiol

bCompounds of natural origin are increasingly used as adjuncts to oral hygiene. We have adopted four distinct approaches to assess the antibacterial activity of dentifrices containing natural active ingredients against oral bacteria in several test systems. Corsodyl Daily (CD), Kingfisher Mint (KM), and Parodontax fluoride (PF) were compared to a dentifrice containing fluoride (Colgate Cavity Protection [CCP]) and one containing triclosan (Colgate Total [CT]). The growth inhibitory and bactericidal potency of the formulations were determined for 10 isolated oral bacteria. Effects of single exposures of simulated supragingival plaques were then determined by epifluorescence and confocal microscopy, while the effects of repeated exposures were quantified by viable counting. Additionally, dense plaques, maintained in continuous culture, were repeatedly dosed, and the outcome was assessed by viable counting and eubacterial DNA profiling. The test dentifrices exhibited variable specificity and potency against oral bacteria in axenic culture. Of the herbal formulations, KM caused the largest viability reductions in simulated supragingival plaques, with CT causing the greatest reductions overall. Following single exposures, CD caused moderate reductions, while PF had no effect. After multiple dosing, all formulations significantly reduced numbers of total, facultative, and Gram-negative anaerobes, but only KM and CT caused greater reductions than the fluoride control. KM also reduced counts of streptococci (rank order of effectiveness: CT > KM > CCP > PF > CD). Marked changes in eubacterial DNA profiles were not detected for any herbal formulation in dense plaques, although KM markedly reduced viable counts of streptococci, in agreement with supragingival data. While both nonherbal comparators displayed antibacterial activity, the triclosan-containing formulation caused greater viability reductions than the herbal and nonherbal formulations.

“…So far, very few attempts have been made to formulate toothpaste containing clove oil or extract. Ellepola et al 2011 compared antifungal activity of various marketed toothpaste brands against clinical isolates of Candida albicans and Candida dubliniensis; and found that brand Dabur Herbal, United Arab Emirates containing clove oil was most active against Candida species and thereby made higher zone of inhibition (tested by Sabouraud agar plate method) 17 Abhay et al 2014. added clove oil to polyherbal toothpaste for taste masking of bitter extracts used.…”

mentioning

confidence: 99%

Pro-Argin Technology Based Formulation of Eugenol Containing Toothpaste

Shete¹,

Patmas²,

Patil³

2020

IJPER

Introduction: Formation of cavities and hyper sensitivity are few dental problems, manifested by dental pain. Since long back, volatile oil present in clove buds (Myrtaceae) have been used as dental analgesic. Various toothpastes containing clove oil are marketed. Eugenol is chemically, terpenoids, active principle present in clove oil. It has several pharmacological potentials. Pro-argin technology is novel approach for formulation of toothpaste with arginine (8%) and calcium carbonate. Aim: This research was aimed towards formulation of toothpaste containing eugenol by Pro-argin technology and its evaluation. Materials and Methods: Toothpaste containing eugenol was formulated with arginine (8%) and calcium carbonate by simple trituration. Formulation was then evaluated for various parameters like pH, spreadability, foaming ability, content determination and also analysed for texture. Results and Discussion: On formulation, brownish, aromatic fragrant toothpaste was obtained with acceptable pH, spreadability and foaming ability. About 92.48% of eugenol content of added quantity was determined. Conclusion: Eugenol can successfully be formulated in toothpaste by Pro-Argin approach. More than 90% content determination would facilitate maximum release of added eugenol.