Pro-Argin Technology Based Formulation of Eugenol Containing Toothpaste

Abstract

Introduction: Formation of cavities and hyper sensitivity are few dental problems, manifested by dental pain. Since long back, volatile oil present in clove buds (Myrtaceae) have been used as dental analgesic. Various toothpastes containing clove oil are marketed. Eugenol is chemically, terpenoids, active principle present in clove oil. It has several pharmacological potentials. Pro-argin technology is novel approach for formulation of toothpaste with arginine (8%) and calcium carbonate. Aim: This research was aimed towards formulation of toothpaste containing eugenol by Pro-argin technology and its evaluation. Materials and Methods: Toothpaste containing eugenol was formulated with arginine (8%) and calcium carbonate by simple trituration. Formulation was then evaluated for various parameters like pH, spreadability, foaming ability, content determination and also analysed for texture. Results and Discussion: On formulation, brownish, aromatic fragrant toothpaste was obtained with acceptable pH, spreadability and foaming ability. About 92.48% of eugenol content of added quantity was determined. Conclusion: Eugenol can successfully be formulated in toothpaste by Pro-Argin approach. More than 90% content determination would facilitate maximum release of added eugenol.

Gelation characteristics of sodium alginate in presence of flavor molecules

“…To the best of our knowledge, there is no published work examining interaction between flavor molecules and calcium in hydrocolloid solutions. We only found a recent study on novel toothpaste formulations where no chemical reaction between eugenol and calcium carbonate was observed (Shete et al., 2020). Moreover, our data indicated no correlation between the AGT and physical properties of flavor molecules (e.g., solubility, boiling point, partition coefficient).…”