A comparison of propofol infusion and propofol/isoflurane anaesthesia in dexmedetomidine premedicated dogs

Abstract

The effects of propofol infusion were compared with propofol/isoflurane anaesthesia in six beagles premedicated with 10 microg/kg intramuscular (i.m.) dexmedetomidine. The suitability of a cold pressor test (CPT) as a stress stimulus in dogs was also studied. Each dog received isoflurane (end tidal 1.0%, induction with propofol) with and without CPT; propofol (200 microg/kg/min, induction with propofol) with and without CPT; premedication alone with and without CPT in a randomized block study in six separate sessions. Heart rate and arterial blood pressures and gases were monitored. Plasma catecholamine, beta-endorphin and cortisol concentrations were measured. Recovery profile was observed. Blood pressures stayed within normal reference range but the dogs were bradycardic (mean heart rate < 70 bpm). PaCO2 concentration during anaesthesia was higher in the propofol group (mean > 57 mmHg) when compared with isoflurane (mean < 52 mmHg). Recovery times were longer with propofol than when compared with the other treatments. The mean extubation times were 8 +/- 3.4 and 23 +/- 6.3 min after propofol/isoflurane and propofol anaesthesia, respectively. The endocrine stress response was similar in all treatments except for lower adrenaline level after propofol infusion at the end of the recovery period. Cold pressor test produced variable responses and was not a reliable stress stimulus in the present study. Propofol/isoflurane anaesthesia was considered more useful than propofol infusion because of milder degree of respiratory depression and faster recovery.

Clinical Comparison of Recovery from Total Intravenous Anesthesia with Propofol and Inhalation Anesthesia with Isoflurane in Dogs

“…However, in one study, dogs recovered slower with propofol TIVA than with propofol/isoflurane anesthesia [6]. The present study showed similar results.…”

“…The present study showed similar results. The prolongation of recovery using propofol TIVA is not compatible with the hypothesis that propofol provides lighter anesthetic planes [5,6]. The slower but smoother recovery in dogs with propofol TIVA may be a physio-pharmacologic feature of the agent and requires further investigation.…”

Recovery Profiles from Dexmedetomidine as a General Anesthetic Adjuvant in Patients Undergoing Lower Abdominal Surgery

“…This is similar to a finding in dogs that dexmedetomidine delayed recovery from propofol, but not from isoflurane. 5 Although these authors postulated a pharmacokinetic explanation, Dutta et al 6 showed that the pharmacokinetic parameters of propofol are not affected by the administration of dexmedetomidine in healthy volunteers. Furthermore, dexmedetomidine and propofol show pharmacodynamic interaction for the sedation and suppression of the motor response.…”

Clinicophysiological and haemodynamic effects of fentanyl with xylazine, medetomidine and dexmedetomidine in isoflurane-anaesthetised water buffaloes (<i>Bubalus bubalis</i>)

“…The high volatility of isoflurane, coupled with low blood solubility, provided relatively rapid induction and recovery and easy control of the depth of anaesthesia. In another study, the recovery time has been reported to be significantly shorter after isoflurane anaesthesia, in comparison to propofol infusion in dexmedetomidine premedicated dogs (Kuusela et al 2003). The short recovery time observed in these groups might be caused by a lower blood gas partition coefficient of isoflurane and faster changes in the alveolar concentration that induced recovery from anaesthesia more rapidly than other inhalant anaesthetics.…”