A comparison of procaine penicillin with sulbactam-ampicillin in the treatment of peritonsillar abscesses

Abstract

The clinical efficacy of procaine penicillin and sulbactam-ampicillin was compared in patients with peritonsillar abscesses after peroral abscess drainage. Forty-two patients were randomly assigned to receive either procaine penicillin or sulbactam-ampicillin intramuscularly on an outpatient basis. The mean time required for clinical symptoms (throat pain, dysphagia and fever) to resolve was compared. No statistically significant difference was found between the clinical recoveries of patients using either antibiotic (P > 0.05). The authors conclude that intramuscular procaine penicillin can be safely prescribed on an outpatient basis to most patients with peritonsillar abscess after incision and drainage. In contrast, a broader spectrum and more expensive antibiotic, such as sulbactam-ampicillin, should be reserved for non-responders.

Medical and surgical treatment of peritonsillar, retropharyngeal, and parapharyngeal abscesses

“…Both Yilmaz et al [41] and Kieff et al [42] compared parenteral administration of penicillin with other broad spectrum antibiotics. In both studies the penicillin regimen was as effective as the broader spectrum antibiotics.…”

“…This data, then, would seem to dictate that the antibiotic treatment of PTA should include antimicrobials such as clindamycin, amoxicillin/clavulanate, or ampicillin/sulbactam. However, studies of the value of microbiologic analysis of the PTA fluid and assessments of the effectiveness of antibiotic regimens brings the use of these antibiotics versus oral or parenteral penicillin into question [1••, [41][42][43][44].…”

The role of oxidants and antioxidants in chronic tonsillitis and adenoid hypertrophy in children

“…If they do not respond to medical treatment and disturb the life of the patient significantly, the treatment of choice is surgery. Despite the frequency of these diseases and the significant morbidity they cause their pathogenesis is not exactly known [2,3].…”

Absceso y flegmón periamigdalino ¿Lo estamos haciendo bien?

“…No existió diferencia significativa al utilizar cualquiera de éstos 15,16 . Según los resultados obtenidos, la penicilina sódica sigue siendo un antimicrobiano de primera elección para este cuadro y no requiere de asociaciones 12 .…”