A Comparison Between Rome III and Rome IV Criteria in Children with Chronic Abdominal Pain: A Prospective Observational Cohort Study

Demirören, Kaan; Güney, Bünyamin; Bostancı, Muharrem; Ekici, Deniz

doi:10.5152/tjg.2022.21893

Cited by 6 publications

(7 citation statements)

References 26 publications

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“…Finally, in 2016, the Rome III criteria for functional gastrointestinal disorders, including IBS, upon which the inclusion and exclusion criteria for this study was based, was supplanted by the Rome IV criteria. While the Rome IV criteria for IBS changed to become more inclusive, 26 published studies are inconsistent in their report of how the prevalence of IBS has changed due to this modification 27–29 . We therefore believe that the change in diagnostic criteria is unlikely to have an impact on the improvements in SBM frequency and abdominal pain demonstrated with linaclotide treatment in this study.…”

Section: Discussionmentioning

confidence: 73%

“…While the Rome IV criteria for IBS changed to become more inclusive, 26 published studies are inconsistent in their report of how the prevalence of IBS has changed due to this modification. [27][28][29] We therefore believe that the change in diagnostic criteria is unlikely to have an impact on the improvements in SBM frequency and abdominal pain demonstrated with linaclotide treatment in this study.…”

Section: Discussionmentioning

confidence: 83%

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Safety and efficacy of linaclotide in children aged 7–17 years with irritable bowel syndrome with constipation

Di Lorenzo,

Nurko,

Hyams

et al. 2023

J. pediatr. gastroenterol. nutr.

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ObjectivesLinaclotide, a guanylate cyclase‐C agonist, was recently approved in the United States for the treatment of children 6–17 years old with functional constipation. This study evaluated the safety and efficacy of various linaclotide doses in children 7–17 years old with irritable bowel syndrome with constipation (IBS‐C).MethodsIn this 4‐week, randomized, double‐blind, placebo‐controlled, parallel‐group, Phase 2 study, children with IBS‐C were randomized to once‐daily placebo or linaclotide (Dose A: 18 or 36 µg, B: 36 or 72 µg, and C: 72 µg or 145 µg, or 290 µg); those aged 7–11 years in a 1:1:1:1 allocation based on weight (18 to <35 kg:18 µg, 36 µg, or 72 µg; or ≥35 kg: 36 µg, 72 µg, or 145 µg), and those aged 12–17 years in a 1:1:1:1:1 allocation (the higher option of Doses A–C or 290 µg). The primary efficacy endpoint was a change from baseline in 4‐week overall spontaneous bowel movement (SBM) frequency rate over the treatment period. Adverse events and clinical laboratory measures were also assessed.ResultsEfficacy, safety, and tolerability were assessed in 101 patients. In the intent‐to‐treat population, numerical improvement was observed in overall SBM frequency rate with increasing linaclotide doses (A: 1.62, B: 1.52, and C: 2.30, 290 µg: 3.26) compared with placebo. The most reported treatment‐emergent adverse events were diarrhea and pain, with most cases being mild and none being severe.ConclusionsLinaclotide was tolerated well in this pediatric population, showing numerical improvement in SBM frequency compared with placebo.

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Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 83%

Safety and efficacy of linaclotide in children aged 7–17 years with irritable bowel syndrome with constipation

Di Lorenzo,

Nurko,

Hyams

et al. 2023

J. pediatr. gastroenterol. nutr.

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“…Subsequently, the Rome criteria provided more structured definitions. Rome II criteria (1999) emphasized symptom duration and frequency, while Rome III (2006) and Rome IV (2016) offered more detailed classifications, including subcategories like Functional Abdominal Pain Syndrome and Irritable Bowel Syndrome [ 41 , 42 ]. This nuanced categorization underscores the importance of recognizing alarm signs indicative of organic abnormalities and acknowledges the complex interplay of psychosocial, genetic, and environmental factors through the gut-brain axis in FAP.…”

Section: Discussionmentioning

confidence: 99%

Effect of cognitive-behavior therapy for children with functional abdominal pain: a meta-analysis

Huang,

Jia,

Zhang

et al. 2024

BMC Gastroenterol

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Background Cognitive-Behavior Therapy (CBT) is the validated non-pharmacological treatment for chronic pain in pediatric patients. While some suggested CBT were comparable to the usual care in reducing children’s functional abdominal pain. This meta-analysis was designed to systematically review the literature for RCTs that investigated the efficacy of CBT in children with functional abdominal pain (FAP). Methods PubMed, Embase, and the Cochrane library were searched for papers published up to October 2022. Studies applying different CBT delivery methods (in-person, web-based, phone-based) were included in this meta-analysis to evaluate the comprehensive effectiveness of CBT compared with usual care. Weighted and standardized mean difference with the 95% confidence intervals were used for the synthesis of the results. Primary outcome was the decrease of functional disability inventory (FDI) and the secondary outcomes were the decrease of severity in pain intensity, depression, anxiety, gastrointestinal symptoms, and improvement in physical quality of life (QoL). Results A total of 10 RCTs with 1187 children were included in the final analysis. The results showed that CBT resulted in better effect in reducing functional disability inventory (SMD=-2.282, 95%CI: -4.537 to -0.027, P = 0.047), pain intensity (SMD=-0.594, 95%CI: -1.147 to -0.040, P = 0.036), and improving QoL (SMD = 14.097, 95%CI: 0.901 to 27.292, P = 0.036) compared with the control groups. Comparable effects were observed in the severity of depression (SMD=-0.493, 95%CI: -1.594 to 0.608, P = 0.380), anxiety (SMD=-0.062, 95%CI: -0.640 to 0.517, P = 0.835), and gastrointestinal symptoms (SMD=-1.096 95%CI: -2.243 to 0.050, P = 0.061) between CBT and usual treatment. Conclusions We observed the differences in post-treatment FAP and pain intensity for children receiving CBT compared with children receiving treatment as usual. CBT in the setting of FAP demonstrates promising developments and highlights the need for future research.

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“…FAPDs are one of the most common disorders in paediatric outpatient clinics and have a high prevalence worldwide [ 14 – 16 ]. Oswari et al [ 17 ] reported that the prevalence of FAPDs in Indonesia among children aged 10–17 years was 11.5% in a study of 1,813 based on Rome III criteria; FD was the most common subtype, with a high prevalence in females.…”

Section: Discussionmentioning

confidence: 99%

Functional abdominal pain disorders in children in southern Anhui Province, China are related to academic stress rather than academic performance

Bao

Chu

et al. 2023

BMC Pediatr

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Background Functional abdominal pain disorders (FAPDs) are one of the most common gastrointestinal disorders in children. The aim of this study was to investigate the prevalence of FAPDs in children in southern Anhui Province, China and their association with academic stress. Methods In this cross-sectional survey, we randomly selected children aged 6–17 years from 11 public schools in southern Anhui Province. FAPDs were diagnosed according to the Rome IV criteria, and a custom-designed questionnaire was used to investigate the association between academic stress and FAPDs in children. Results A total of 2,344 children aged 6–17 years were enrolled. The mean age was 12.4 ± 3.0 years. Of these children, 335 (14.3%) were diagnosed with FAPDs according to the Rome IV criteria. Among the children with FAPDs, 156 (46.6%) were boys, and 179 (53.4%) were girls. The prevalence was higher in girls than in boys. The most common disorder was irritable bowel syndrome (IBS) (n = 182 (7.8%)). Other types of FAPDs included functional abdominal pain–not otherwise specified (FAPNOS) (n = 70 (3.0%)), functional dyspepsia (FD) (n = 55 (2.3%)), and abdominal migraine (AM) (n = 28 (1.2%)). Academic stress, not meeting parental expectations, poor relationships with parents, and sleep disturbances were independent risk factors for FAPDs in children; academic performance was not associated with the development of FAPDs. Conclusion There was a high prevalence of FAPDs among children in southern Anhui Province, China, and IBS was the most common subtype of functional abdominal pain. Academic stress, rather than academic performance, was associated with FAPDs in children.

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A Comparison Between Rome III and Rome IV Criteria in Children with Chronic Abdominal Pain: A Prospective Observational Cohort Study

Cited by 6 publications

References 26 publications

Safety and efficacy of linaclotide in children aged 7–17 years with irritable bowel syndrome with constipation

Safety and efficacy of linaclotide in children aged 7–17 years with irritable bowel syndrome with constipation

Effect of cognitive-behavior therapy for children with functional abdominal pain: a meta-analysis

Functional abdominal pain disorders in children in southern Anhui Province, China are related to academic stress rather than academic performance

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