Safety and efficacy of linaclotide in children aged 7–17 years with irritable bowel syndrome with constipation
Carlo Di Lorenzo,
Samuel Nurko,
Jeffrey S. Hyams
et al.
Abstract:ObjectivesLinaclotide, a guanylate cyclase‐C agonist, was recently approved in the United States for the treatment of children 6–17 years old with functional constipation. This study evaluated the safety and efficacy of various linaclotide doses in children 7–17 years old with irritable bowel syndrome with constipation (IBS‐C).MethodsIn this 4‐week, randomized, double‐blind, placebo‐controlled, parallel‐group, Phase 2 study, children with IBS‐C were randomized to once‐daily placebo or linaclotide (Dose A: 18 o… Show more
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