A comparative toxicological study on pike (Esox lucius L.) from the river Rhine and river Lahn

Koss, G.; Schüler, E.; Arndt, B.; Seidel, Jutta; Seubert, S.; Seubert, Andreas

doi:10.1016/0166-445x(86)90068-8

Cited by 14 publications

(7 citation statements)

References 19 publications

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“…The accumulation of HCP and coproporphyrin may be caused by a blockage of UROD and CPG activity by components of BKME. The effect is similar to that observed in the previous studies in birds, pike, and chick embryo liver cell culture (Marks et al, 1983;Koss et al, 1986;Kennedy and Fox, 1990).…”

Section: Porphyrin Profilessupporting

confidence: 89%

“…Recent studies have also shown an increase of highly carboxylated porphyrins (HCP, i.e., sum of uro-, hepta-, hexa-, and pentaporphyrin) in wild birds from the Great Lakes (Fox et al, 1988;Kennedy and Fox, 1990). A similar result has been found in pike (Esox lucius) from the Rhine River, heavily contaminated by hexachlorobenzene, hexachlorobiphenyl, DDT, and DDE (Koss et al, 1986). Furthermore, a dose-response relationship between exposure to hexachlorobenzene and levels of HCP in rats has also been reported (Kennedy and Wigfield, 1990).…”

Section: Introductionsupporting

confidence: 57%

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Suitability of carboxylated porphyrin profiles as a biochemical indicator in whitefish (Coregonus clupeaformis) exposed to bleached kraft pulp mill effluent

Xu¹,

Lesage²,

Munkittrick

1994

Environ. Toxicol. Water Qual.

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The hepatic carboxylated porphyrin profile was studied in whitefish exposed to bleached kraft pulp mill effluent (BKME). The distribution of the porphyrins was different between the samples from the BKME and the reference site, and fish exposed to BKME contained higher amounts of highly carboxylated porphyrins (HOP). The ratios of HCP to protoporphyrin, and coproporphyrin to protoporphyrin, were also significantly different between the two groups. In addition, the cytochrome P‐450 activity, liversomatic index, and gonadosomatic index were measured and compared with the prophyrin profile. The results suggest that BKME could inhibit porphyrinogen decarboxylases, and the porphyrin profile is useful as a biochemical indicator for identification of BKME exposure. © 1994 by John Wiley & Sons, Inc..

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Section: Porphyrin Profilessupporting

confidence: 89%

Section: Introductionsupporting

confidence: 57%

Suitability of carboxylated porphyrin profiles as a biochemical indicator in whitefish (Coregonus clupeaformis) exposed to bleached kraft pulp mill effluent

Xu¹,

Lesage²,

Munkittrick

1994

Environ. Toxicol. Water Qual.

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“…HCP levels in the livers of pike, Esox lucius, from the highly polluted Rhine River were markedly higher than those in pike from the less contaminated Lahn River [34]. Ours is the first report of elevated HCP levels in wild birds.…”

Section: -22mentioning

confidence: 56%

Porphyria in herring gulls: A biochemical response to chemical contamination of great lakes food chains

Fox

Norstrom

Wigfield

et al. 1988

Enviro Toxic and Chemistry

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Concentrations of highly carboxylated porphyrins (HCPs) in the livers of adult herring gulls (Larus argentatus) from colonies throughout the Great Lakes were found to be markedly elevated in comparison with those in gulls from coastal areas and in seven other species of birds consuming diets uncontaminated with polyhalogenated aromatic hydrocarbons (PHAHs). The highes levels were found in gulls from lower Green Bay (Lake Michigan), Saginaw Bay (Lake Huron) ant Lake Ontario. We suggest that the high levels of HCPs reflect PHAH‐induced derangement of heme biosynthesis. Determination of HCPs offers promise as a specific and sensitive biological marker of PHAH‐induced toxicity and as a measure of the toxicological significance of the chemical burden in gulls, terminal members of Great Lakes food chains.

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“…In recent years, water from the Rhine has caused elevated occurrence of chromosomal aberrations (Prein et al, 1978), chromosome breakage (Koss et al, 1986), tumours and porphyrin levels (Slooff and De Zwart, 1983) in fish compared to those from cleaner waters. These studies are valuable since they give information on the effects caused by the complex mixture of chemicals in the river.…”

Section: Hazard Assessmentmentioning

confidence: 99%

Animal Biomarkers as Pollution Indicators

Peakall¹

1992

255

175

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A comparative toxicological study on pike (Esox lucius L.) from the river Rhine and river Lahn

Cited by 14 publications

References 19 publications

Suitability of carboxylated porphyrin profiles as a biochemical indicator in whitefish (Coregonus clupeaformis) exposed to bleached kraft pulp mill effluent

Suitability of carboxylated porphyrin profiles as a biochemical indicator in whitefish (Coregonus clupeaformis) exposed to bleached kraft pulp mill effluent

Porphyria in herring gulls: A biochemical response to chemical contamination of great lakes food chains

Animal Biomarkers as Pollution Indicators

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