1992
DOI: 10.1007/978-94-011-2346-4
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Animal Biomarkers as Pollution Indicators

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Cited by 255 publications
(182 citation statements)
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References 358 publications
(479 reference statements)
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“…We examined tadpole livers for evidence of histopathology such as necrosis, lesions, hepatocyte degeneration and vacuolation. PAHs can also 2 3 2 interfere with the heme biosynthetic pathway and lead to hepatic porphyria in which the liver accumulates excess uroporphyrin (Peakall 1992). Because uroporphyrin is the porphyrin most affected by PCBs and other PAHs, we measured uroporphyrin levels in tadpole livers.…”
Section: Introductionmentioning
confidence: 99%
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“…We examined tadpole livers for evidence of histopathology such as necrosis, lesions, hepatocyte degeneration and vacuolation. PAHs can also 2 3 2 interfere with the heme biosynthetic pathway and lead to hepatic porphyria in which the liver accumulates excess uroporphyrin (Peakall 1992). Because uroporphyrin is the porphyrin most affected by PCBs and other PAHs, we measured uroporphyrin levels in tadpole livers.…”
Section: Introductionmentioning
confidence: 99%
“…Because uroporphyrin is the porphyrin most affected by PCBs and other PAHs, we measured uroporphyrin levels in tadpole livers. Additionally, induction of cytochrome P450 (cyp P450) enzymes, a large family of metabolizing and detoxifying liver enzymes, has been used as a sensitive biomarker for organic pollutant exposure (Peakall 1992). …”
Section: Introductionmentioning
confidence: 99%
“…Assessment of the effects of hazardous chemicals on human health has concentrated on the individual, and on organ, cellular, and subcellular causes of ill health (5,8). This has led to investigations aimed at identifying the mechanisms of action of the causative agents.…”
Section: Introductionmentioning
confidence: 99%
“…At every level of ecological organization, from the individual to ecosystems, there are indicators or measures (biomarkers or bioindicators) of well-being (5,6). At the population level, population stability is the end point of concern (21).…”
Section: Introductionmentioning
confidence: 99%
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