A Comparative Study of Thyroid Hormone and Lipid Status of Patient with and without Diabetes in Adults

Abstract

Introduction: Lipid and thyroid function abnormalities are common in IDDM and NIDDM. Very few studies have addressed this issue in Bangladesh though Bangladeshi population is very much susceptible to patient with diabetes. Aims: To study on lipid profile and thyroid function in IDDM and NIDDM and the effect of glycemic control on it. Patients and Methods: This was a retrospective study carried out in the Dept. of Endocrinology, BIRDEM, Dhaka, Bangladesh during the period of January, 2012 to May, 2012. In this study, population consisted of 120 subjects (Age between 40-72 years; and Sex matched) divided into two groups: patient with diabetes 60 subjects (male-30, female-30) and patient without diabetes 60 subjects (male-30, female-30). Plasma glucose, HbA1c and serum lipids were measured by enzymatic method. Thyroid hormones were measured by a Chemiluminescent Micro particle Immunoassay (CMIA). Results: The statistical significance was evaluated by Student's t-test, Correlation-Coefficient test. All Values are given as mean ± SD. The level of serum TSH in patient with diabetes (3.43 ± 2.71) was significantly (p < 0.05) increased compared to patient without diabetes subjects (1.98 ± 1.72). TSH levels were positively correlated with fasting plasma glucose (r = 0.240, p < 0.05), serum cholesterol (r = 0.290, p < 0.020) and triglyceride concentration (r = 0.246, p < 0.05). On the other hand, free T 4 levels were inversely correlated with postprandial blood glucose (r = −0.256, p < 0.046). Conclusions: It may be concluded that the lipid and thyroid function abnormalities with others socio-demographic and biophysical risk factors were more common in patient with diabetes cases rather than patient without diabetes cases. Therefore, further prospective studies with larger number of patients are required to strengthen the observations of the present study.

Correlation Between Glycosylated Haemoglobin, Lipid Profile and Thyroid Function Among Patients With Type 2 Diabetes Mellitus

“…Since the measurement of HbA1c levels is important not only for monitoring of diabetes, the results of our study showed an obvious elevation of HbA1c levels in patients diagnosed with DM are in corroboration with the results of Vikhe et al, and Saha et al [10,11] Consequently impaired lipid metabolism resulting from uncontrolled hyperglycaemia has been implicated in cardiovascular complications in diabetes patients, this fact support our result which showed a relation between HbA1c, total cholesterol and LDL in patients with DM, which are also confirmed by Khan et al, [12] who stated that HbA1c exhibited direct correlations with cholesterol and LDL Our observation on the lack of variation in TSH level is not in harmony with the results of Cappelli et al, [13] these differences appear to be also due to DM medications. Furthermore, the result of correlation test showed a positive correlation between HbA1c and TSH in type 2 DM, these observations are consistent with previous studies Udiong et al, [14] who reported significant association between HbA1c and TSH.…”

“…[9,10] The presence of diabetes is also related to the insufficiency of the replacement of thyroid hormone in elderly patients with hypothyroidism. [11] Since, adequate glycemic control can delay development of diabetic complication, the purpose of this study was to measure HbA1c in diabetic patients and bring out a possible correlation between thyroid hormones, HbA1c and different types of lipids, in order to highlight the significance of such a correlation which can prevent exacerbation of cardiovascular risk-related mortality.…”

Thyroid Hormonal Status in Newly Diagnosed Type 2 Diabetes Mellitus

“…HbA1c (10.11 ± 1.08) % and (5.52 ± 0.52) % in group I and group II respectively is higher in this study both in diabetic and non-diabetic individuals than the study conducted by Vikhe et al (7.38 ± 0.72% and 5.12 ± 0.21 in diabetic and non-diabetic subjects respectively (11). Saha et al (6) found HbA1C in diabetic and non-diabetic subjects are almost same as present study.…”

Prospective Study of Thyroid Function and Its Correlation With Lipid Parameter in Patients With Diabetes and Hypertensive Diabetes

“…9 Saha et al in their study of 120 subjects in Bangladesh compared the thyroid function between patients with and without diabetes and they reported significantly higher level of lipid parameters as compared to non-diabetes patients, which is contrary to present study data as we have compared the lipid parameters between diabetes and hypertensive diabetes, which signifies that hypertension does not contribute in abnormal thyroid function. 10 Saha et al also correlated different lipid parameters with thyroid functions and reported that total cholesterol and HDL-C were negatively correlated with T4, whereas total cholesterol and triglyceride were positively correlated with TSH. 10 A study done by Singh et al including 80 T2DM Punjabi population revealed higher level of thyroid function, lower level of HDL-C and raised level of LDL-C, triglyceride, total cholesterol and VLDL-C as compared to non-diabetic patients.…”