A comparative study of therapeutic response to intralesional injections of platelet-rich plasma versus triamcinolone acetonide in alopecia areata

Balakrishnan, Anumod; Joy, Bifi; Thyvalappil, Anoop; Mathew, Pretty; Sreenivasan, Ajayakumar; Sridharan, Rajiv

doi:10.4103/idoj.idoj_6_20

Cited by 18 publications

(24 citation statements)

References 16 publications

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“…Balakrishnan et al found no statistically significant difference between the SALT scores of the two groups when compared at different timepoints; however, the response in the PRP group was better than that in the TrA group [16]. When the decrease in the SALT score at different timepoints was investigated, there was a significant difference in the decrease in the SALT score between the PRP group and the TrA group at the second evaluation, 4 weeks after the first treatment session (p = 0.028) [16]. After the last evaluation (12 weeks after the first treatment session), there was no statistically significant difference between the two groups [16].…”

Section: Main Characteristics Of the Included Studiesmentioning

confidence: 96%

“…When the decrease in the SALT score at different timepoints was investigated, there was a significant difference in the decrease in the SALT score between the PRP group and the TrA group at the second evaluation, 4 weeks after the first treatment session (p = 0.028) [16]. After the last evaluation (12 weeks after the first treatment session), there was no statistically significant difference between the two groups [16]. Trink et al found that the SALT score decreased significantly in the PRP group compared with the TrA group (p < 0.001) [20].…”

Section: Main Characteristics Of the Included Studiesmentioning

confidence: 99%

“…Our systematic search provided a total of 2747 articles; after duplicate removal, we screened 2002 duplicate-free articles. After the title, abstract, and full-text selection, we identified six RCTs matching our PICO framework [15][16][17][18][19][20]; of these articles, we could use four RCTs for our quantitative synthesis [15,[17][18][19]. The results of the other two articles [16,20] and the results of two additional articles, which also included a placebo as a comparator [18,20], are discussed in the systematic review with the secondary outcomes.…”

Section: Search and Selectionmentioning

confidence: 99%

“…All studies included in our systematic review and meta-analysis showed a significant decrease in the SALT scores for PRP and TrA groups [15][16][17][18][19][20].…”

Section: Main Characteristics Of the Included Studiesmentioning

confidence: 99%

“…Several studies have reported promising results of PRP in the treatment of AA [15][16][17][18][19][20], but there has been no systematic evaluation of randomized trials reporting on the therapeutic effect of PRP on AA to date. Our aim was to investigate the therapeutic effects of PRP in the treatment of limited patchy AA by conducting a systematic review and meta-analysis, comparing PRP with the first line of treatment in limited patchy AA, TrA [10,13].…”

Section: Introductionmentioning

confidence: 99%

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588 Platelet-rich plasma in alopecia areata – a steroid-free treatment modality. A systematic review and meta-analysis of randomized clinical trials

Meznerics

Illés

Dembrovszky

et al. 2022

Journal of Investigative Dermatology

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Section: Main Characteristics Of the Included Studiesmentioning

confidence: 96%

Section: Main Characteristics Of the Included Studiesmentioning

confidence: 99%

Section: Search and Selectionmentioning

confidence: 99%

“…All studies included in our systematic review and meta-analysis showed a significant decrease in the SALT scores for PRP and TrA groups [15][16][17][18][19][20].…”

Section: Main Characteristics Of the Included Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

588 Platelet-rich plasma in alopecia areata – a steroid-free treatment modality. A systematic review and meta-analysis of randomized clinical trials

Meznerics

Illés

Dembrovszky

et al. 2022

Journal of Investigative Dermatology

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Autologes plättchenreiches Plasma in der Behandlung der Alopezie

Reith¹

2021

Aktuelle Dermatologie

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ZusammenfassungAutologes plättchenreiches Plasma wird aufgrund seiner wundheilenden Eigenschaften vielfach angewandt u. a. in Orthopädie, Chirurgie und Dermatologie. Zunehmend stellt plättchenreiches Plasma außerdem bei bestimmten Formen der Alopezie eine interessante neue Behandlungsoption dar, sei es als alleinige Therapie oder auch als Adjuvans im Rahmen einer Haartransplantation. Kontrollierte klinische Studien an kleineren Patientengruppen zeigten vielfach positive Ergebnisse, größere Studien stehen bislang noch aus. Die Wirkung auf das Haarwachstum wird sehr wahrscheinlich über die in plättchenreichem Plasma enthaltenen Wachstumsfaktoren und Zytokine vermittelt.

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Efficacy of Jessener solution versus intralesional steroid in treatment of alopecia areata

Elshahid

Kadah

Hassan

et al. 2022

J of Cosmetic Dermatology

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Background Alopecia areata is an autoimmune condition that causes non‐scarring hair loss. To date, there is no single cure and treatment remains challenging. Objectives To evaluate the efficacy of Jessener solution versus intralesional steroid in treatment of Alopecia Areata. Methods This study included 40 patients who presented with multifocal patchy alopecia areata (AA). For each patient, three patches were randomly selected to be treated one with intralesional steroid, another with topical Jessner solution and the third with normal saline. Three sessions were done 3 weeks apart and were followed up for 3 months. Response was assessed clinically and by trichoscope. Results Fifteen percent of patches coated with Jessner or injected with steroids showed an excellent response while 20% of patches coated with Jessner and 32.5% patches injected with steroids showed a good response. A significant difference was observed between the three modalities of treatment regarding the prognostic score for response (p < 0.001) as patches coated with Jessner and those steroid injected showed a significant higher response rate than patches injected with saline (p < 0.001) while no significant difference was reported between patches either treated with Jessner or steroids (p > 0.05). Conclusion Jessners solution can be a novel and feasible and well tolerated modality of treatment for patients suffering from alopecia areata.

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A comparative study of therapeutic response to intralesional injections of platelet-rich plasma versus triamcinolone acetonide in alopecia areata

Cited by 18 publications

References 16 publications

588 Platelet-rich plasma in alopecia areata – a steroid-free treatment modality. A systematic review and meta-analysis of randomized clinical trials

588 Platelet-rich plasma in alopecia areata – a steroid-free treatment modality. A systematic review and meta-analysis of randomized clinical trials

Autologes plättchenreiches Plasma in der Behandlung der Alopezie

Efficacy of Jessener solution versus intralesional steroid in treatment of alopecia areata

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