Efficacy of Jessener solution versus intralesional steroid in treatment of alopecia areata

Abstract

Background Alopecia areata is an autoimmune condition that causes non‐scarring hair loss. To date, there is no single cure and treatment remains challenging. Objectives To evaluate the efficacy of Jessener solution versus intralesional steroid in treatment of Alopecia Areata. Methods This study included 40 patients who presented with multifocal patchy alopecia areata (AA). For each patient, three patches were randomly selected to be treated one with intralesional steroid, another with topical Jessner solution and the third with normal saline. Three sessions were done 3 weeks apart and were followed up for 3 months. Response was assessed clinically and by trichoscope. Results Fifteen percent of patches coated with Jessner or injected with steroids showed an excellent response while 20% of patches coated with Jessner and 32.5% patches injected with steroids showed a good response. A significant difference was observed between the three modalities of treatment regarding the prognostic score for response (p < 0.001) as patches coated with Jessner and those steroid injected showed a significant higher response rate than patches injected with saline (p < 0.001) while no significant difference was reported between patches either treated with Jessner or steroids (p > 0.05). Conclusion Jessners solution can be a novel and feasible and well tolerated modality of treatment for patients suffering from alopecia areata.

Dermoscopy-assisted prevalence of hair loss after COVID-19 vaccination among an Egyptian population: a cross-sectional study

“…Alopecia areata (AA), characterized by patchy hair loss from the scalp, is an autoimmune condition precipitated by loss of immune privilege in the hair bulge leading to concentrates of natural killer (NK) cells within hair follicles [ 11 , 12 ]. In the present study, new onset AA and recurrent AA were among the reported hair loss features among participants.…”

“…Moreover; this exaggerated production of IFNs can contribute to suppressing immunity and further promoting the development of AA. These findings suggest a potential role of vaccines to trigger autoimmunity, as observed in patients vaccinated for hepatitis B and hepatitis A that showed a significantly higher prevalence of alopecia areata [ 12 ].…”

Higher percentage of CD34+ stem cells and elevated efficacy in androgenetic alopecia treatment observed in CGF prepared from 640 nm laser‐pretreated blood: A preliminary study

“…A follow‐up visit was performed 1 month after treatment, and hair growth on the left and right sides of the scalp was obtained for each patient using a trichoscope (Beining, Nanjing) 23 according to the literature. The number of new hair growths and malnourished hairs was recorded under the trichoscope by two dermatologists who did not participate in the CGF preparation and administration.…”