A comparative study of microneedling with platelet-rich plasma plus topical minoxidil (5%) and topical minoxidil (5%) alone in androgenetic alopecia

Shah, Kaksha B; Shah, Aarti; Solanki, Rekha; Raval, Ranjan C

doi:10.4103/ijt.ijt_75_16

Cited by 64 publications

(75 citation statements)

References 14 publications

(16 reference statements)

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“…Moreover, the increase in transepidermal drug delivery is observed for at least 72 hr after the procedure (Lima, Lima, Paixão, & Miot, ). The microtraumatization creates micropores, which results in increased transdermal water loss (Šuca et al, ), however, the result of the study has demonstrated that prompt recovery of skin barrier function is achieved within several hours from device usage (Shah, Shah, Solanki, & Raval, ).…”

Section: Most Commonly Used Devicesmentioning

confidence: 99%

See 1 more Smart Citation

Is skin microneedling a good alternative method of various skin defects removal

Zduńska

Kołodziejczak

Rotsztejn

2018

Dermatologic Therapy

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Skin microneedling accelerates the process of skin regeneration through the creation of numerous microinjuries which emerge when skin is deeply punctured with very thin needles. The whole procedure evokes various reactions which can be divided into three major phases: inflammation, proliferation, and remodeling. It activates platelet growth factors which are responsible for the stimulation of fibroblasts to produce collagen and elastin. Moreover, skin breakdown enhances penetration of active ingredients. Treatment can be performed with the use of different devices, all equipped with needles of various lengths. Due to the fact that skin microneedling stimulates the synthesis of significant rebuilding and structural skin elements (collagen, elastin, proteoglycan), it is used in the treatment of many skin defects of different etiologies (e.g., photoaging, wrinkles, loss of elasticity, hypo‐ or hypertrophic scars, pigmentation changes, infraorbital dark circles, teleangiectasia, stretch marks, cellulite, alopecia, and vitiligo). In order to accelerate postsurgical regeneration and/or to enhance effects, microneedling is combined with the application of UV light (photodynamic therapy with ALA), LED light, platelet‐rich plasma, chemical peels, stem cells, retinoids and other pharmaceuticals, and vitamins. High effectiveness, limited number of side effects, and short recovery time, make skin microneedling a popular cosmetic, and medical treatment.

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Section: Most Commonly Used Devicesmentioning

confidence: 99%

“…Fifty patients were randomly divided into two groups of 25 patients. There was a significant improvement ( p < 0.05) in Group B as compared to Group A. Microneedling with PRP is safe and effective for the management of androgenetic alopecia (Shah et al, ).…”

Section: Main Indications For the Application Of Microneedlingmentioning

confidence: 99%

Is skin microneedling a good alternative method of various skin defects removal

Zduńska

Kołodziejczak

Rotsztejn

2018

Dermatologic Therapy

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“…Platelet‐rich plasma was applied one to eight times during a treatment period, which lasted from one to 5 months. Three studies applied co‐interventions (minoxidil, finasteride, or polydeoxyribonucleotide) in addition to PRP in the experimental group and applied the same intervention in the control group without PRP . The rest of 10 studies compared platelet‐rich plasma to placebo (normal saline or distilled water) .…”

Section: Resultsmentioning

confidence: 99%

Autologous platelet‐rich plasma therapy for pattern hair loss: A systematic review

Dervishi

Peternel

et al. 2019

J of Cosmetic Dermatology

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Background Androgenetic alopecia (male pattern and female pattern hair loss) is characterized by thinning of the scalp hair. Intradermal injection of autologous platelet‐rich plasma (PRP) might have an effect on hair regrowth. Aims The aim was to evaluate efficacy and safety of platelet‐rich plasma compared to placebo or no treatment in people with pattern hair loss. Patients/Methods We searched the databases CENTRAL and MEDLINE on December 24, 2018 and included randomized controlled trials (RCTs). Primary outcomes were mean change of hair density from baseline and serious treatment‐related adverse events. Secondary outcome was mean change of hair thickness from baseline. Time point of outcome assessment was 6 months after start of treatment. Results We identified 13 relevant randomized controlled trials with 356 randomized (343 analyzed) people or half‐head areas who received PRP in a simple parallel or half‐head design. The pooled data of seven studies (171 analyzed people or half‐head areas) were favorable in the PRP group on hair density. We estimated a mean difference from baseline of 30.35 associated with a wide 95% confidence interval (1.77‐58.93), a considerable heterogeneity (I2 = 100%), and unclear risk of bias in most of the studies. Regarding hair thickness, data were also favorable in the PRP group, but these data were limited to a single study. We did not identify serious treatment‐related adverse events. Conclusion The results of seven RCTs indicated that autologous platelet‐rich plasma was associated with an increase of hair density when compared to placebo.

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“…Reference lists were also reviewed to minimize the risk of missing relevant articles. After a comprehensive full‐text review of all articles identified by our search strategy, a total of 15 articles met inclusion and exclusion criteria for analysis . One article reported on and compared 3 preparation methods and was treated as 3 separate studies for the purpose of tabulating study characteristics .…”

Section: Methodsmentioning

confidence: 99%