Systematic review of platelet‐rich plasma (<scp>PRP</scp>) preparation and composition for the treatment of androgenetic alopecia

Kramer, MaryJo E; Keaney, Terrence

doi:10.1111/jocd.12679

Cited by 51 publications

(34 citation statements)

References 46 publications

(86 reference statements)

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“…Nevertheless, the data from this small pilot study does suggest it may be possible to determine the most significant growth factors, and their optimal concentrations for efficacy, with larger trials involving comparative cohorts. Attempts to objectively investigate the effects of PRP, with quantification of hair growth and comparison to defined PRP characteristics, should be a priority …”

Section: Discussionmentioning

confidence: 99%

“…Attempts to objectively investigate the effects of PRP, with quantification of hair growth and comparison to defined PRP characteristics, should be a priority. [32,51,52]…”

Section: Limitationsmentioning

confidence: 99%

“…Pilot studies have also evaluated the efficacy of PRP for treating alopecia areata and were found to improve hair growth . Recent reviews of PRP for the treatment of hair loss conclude that, though clearly still in a nascent stage, the use of PRP for alopecia is promising and the side effects are relatively limited …”

Section: Introductionmentioning

confidence: 99%

“…[28][29][30] Recent reviews of PRP for the treatment of hair loss conclude that, though clearly still in a nascent stage, the use of PRP for alopecia is promising and the side effects are relatively limited. [31][32][33] With the current study, we aimed to investigate the effects of intradermal PRP injections on androgenetic alopecia (AGA) and quantify select growth factors in PRP. We used an intra-control, defined area, quantitative analysis, placebo-controlled design in a pilot study to determine the effects of PRP on hair growth in AGA subjects.…”

Section: Introductionmentioning

confidence: 99%

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Growth factor concentrations in platelet‐rich plasma for androgenetic alopecia: An intra‐subject, randomized, blinded, placebo‐controlled, pilot study

Siah

Guo

Chu

et al. 2020

Experimental Dermatology

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Background Platelet‐rich plasma (PRP), processed from autologous peripheral blood, is used to treat androgenetic alopecia (AGA). Objective To determine the efficacy of PRP for hair growth promotion in AGA patients in a randomized, blinded, placebo‐controlled, pilot clinical trial (NCT02074943). Methods The efficacy of an 8 week, five session, PRP treatment course was determined by measuring hair density and hair caliber changes in 10 AGA affected patients. For each PRP sample, the concentrations of selected growth factors were determined using a multiplex assay system. The clinical results were then correlated with the growth factor concentrations in PRP. Results At 16 weeks, 8 weeks after the last PRP injection, treated areas exhibited increased mean hair density (+12.76%) over baseline compared to placebo (+0.99%). Mean hair caliber decreased in both treated and placebo regions (−16.22% and −19.46%, respectively). Serial analysis of PRP significant variability in concentrations between patients. Overall, there was a positive correlation between GDNF concentration and hair density (P = .004). Trends, though not statistically significant, were also observed for FGF2 and VEGF. Limitations Small sample size and lack of comparative cohorts receiving protocol variations limit confidence in the study data. Conclusions This small pilot clinical trial suggests PRP treatment may be beneficial for AGA. However, the variable hair growth responses between patients indicate there is a significant opportunity to improve PRP therapy protocols for hair growth promotion. The variability in growth factor concentration in PRP suggests standardization of growth factors postprocessing might improve hair growth responses.

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Section: Discussionmentioning

confidence: 99%

“…Attempts to objectively investigate the effects of PRP, with quantification of hair growth and comparison to defined PRP characteristics, should be a priority. [32,51,52]…”

Section: Limitationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Growth factor concentrations in platelet‐rich plasma for androgenetic alopecia: An intra‐subject, randomized, blinded, placebo‐controlled, pilot study

Siah

Guo

Chu

et al. 2020

Experimental Dermatology

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“…The use of PRP has been increasing, and different techniques have been described; among them, tubes with ACD-A, tubes with ficoll and kits for cellular separation have been used. [5][6][7][8] Esra et al 9 made a comparison of the aforementioned concluding that the use of tubes with ACD-A is superior to the tubes with ficoll, and no statistically significant difference was found with the cellular separation kits. 9 We used ACD-A tubes with good results.…”

Section: Discussionmentioning

confidence: 99%

Consistency and reproducibility in the platelet‐rich plasma preparation method: Mexican experience

Ancer-Arellano

Villarreal‐Martínez

Vazquez-Martínez

et al. 2019

Int J Lab Hematology

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Effect of Platelet-Rich Plasma Injection for Rejuvenation of Photoaged Facial Skin

et al. 2018

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IMPORTANCE There remains little experimental evidence and no randomized clinical trial to date to confirm the benefit of platelet-rich plasma (PRP) for facial rejuvenation. OBJECTIVE To investigate whether PRP injection improves the visual appearance, including texture and color, of photodamaged facial skin. DESIGN, SETTING, AND PARTICIPANTS In this randomized clinical trial, participants and raters were masked to groupings. The setting was an academic-based, urban outpatient dermatology practice in Chicago, Illinois. Participants were adults aged 18 to 70 years with bilateral cheek rhytids of Glogau class II or greater. The duration of the study was August 21, 2012, to February 16, 2016. INTERVENTIONS Each participant received 3 mL intradermal injections of PRP to one cheek and sterile normal saline to the contralateral cheek. MAIN OUTCOMES AND MEASURES Primary outcomes were photoaging scores (with subscores for fine lines, mottled pigmentation, roughness, and sallowness) as rated by 2 masked dermatologists. Secondary outcomes included participant self-assessment scores of improvement on a 5-point scale (worsening, no change, mild improvement, moderate improvement, or significant improvement), participant overall satisfaction scores on a 4-point scale (not satisfied, slightly satisfied, moderately satisfied, or very satisfied), and participant-reported or investigator-observed adverse events. RESULTS Of 27 enrolled participants, 19 (mean [SD] age, 46.37 [10.88] years; 17 female) were analyzed. Reported adverse events, which were not associated with the study agent, included redness (n = 18), swelling (n = 16), bruising (n = 14), pruritus (n = 1), skin scaling (n = 1), and dryness of skin (n = 1). No participants reported any adverse events at 12 months. Mean (SD) photoaging scores rated by 2 dermatologists showed no significant difference between PRP and normal saline for fine lines (baseline, 1.

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Systematic review of platelet‐rich plasma (PRP) preparation and composition for the treatment of androgenetic alopecia

Abstract: The current reporting of PRP preparation methodology and final composition is inconsistent and insufficient to enable comparison between studies and determination of efficacy for particular treatment applications.

Cited by 51 publications

References 46 publications

Growth factor concentrations in platelet‐rich plasma for androgenetic alopecia: An intra‐subject, randomized, blinded, placebo‐controlled, pilot study

Growth factor concentrations in platelet‐rich plasma for androgenetic alopecia: An intra‐subject, randomized, blinded, placebo‐controlled, pilot study

Consistency and reproducibility in the platelet‐rich plasma preparation method: Mexican experience

Effect of Platelet-Rich Plasma Injection for Rejuvenation of Photoaged Facial Skin

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