A comparative study of immunohistochemical markers in the detection of early myocardial infarction (an autopsy study)

Amin, Hebat Allah; Abdelal, Heba; Shabaiek, Amany; Osman, Ghada S.; Mousa, Amany M.

doi:10.1097/01.xej.0000465414.47169.95

Cited by 2 publications

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“…Many studies have proved the usefulness of variable immunohistochemical markers (especially Troponin, myoglobin, C5a, S100a1 and desmin) in the diagnosis of early myocardial injury has been promoted because most of them can be visible very early after the beginning of the symptoms (chest pain and angina attacks) [ 13 - 16 ].…”

Section: Discussionmentioning

confidence: 99%

Role of Cardiac Myocytes Heart Fatty Acid Binding Protein Depletion (H-FABP) in Early Myocardial Infarction in Human Heart (Autopsy Study)

Shabaiek

Ismael²,

Elsheikh³

et al. 2016

Open Access Maced J Med Sci

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BACKGROUND:Many immunohistochemical markers have been used in the postmortem detection of early myocardial infarction.AIM:In the present study we examined the role of Heart-type fatty acid binding protein (H-FABP), in the detection of early myocardial infarction.MATERIAL AND METHODS:We obtained samples from 40 human autopsy hearts with/without histopathological signs of ischemia.RESULTS:All cases of definite and probable myocardial infarction showed a well-defined area of H-FABP depletion. All of the control cases showed strong H-FABP expression, except two markedly autolysed myocardial samples that showed affected antigenicity.CONCLUSION:Thus, we suggest H-FABP as being one of the valuable tools facing the problem of postmortem detection of early myocardial infarction/ischemia, but not in autolysis.

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Section: Discussionmentioning

confidence: 99%