Role of Cardiac Myocytes Heart Fatty Acid Binding Protein Depletion (H-FABP) in Early Myocardial Infarction in Human Heart (Autopsy Study)

Shabaiek, Amany; Ismael, Nour El-Hoda; Elsheikh, Samar A. M.; Amin, Hebat Allah

doi:10.3889/oamjms.2016.018

Cited by 10 publications

(4 citation statements)

References 12 publications

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“…As such, both hs-TnT and h-FABP are sensitive indicators of myocardial injury. Previous studies have reported that the concentration of h-FABP in peripheral blood in patients with MI is related to coronary artery disease severity and can be used to assess the area of MI and cardiovascular prognosis in patients with acute ST-segment elevation MI (STEMI) [ 17 ]. The results of our study show that the increase in hs-TnT and h-FABP after PCI in the ticagrelor group was significantly smaller than in the clopidogrel group.…”

Section: Discussionmentioning

confidence: 99%

Comparison of ticagrelor and clopidogrel on platelet function and prognosis in unstable angina

Liu

Chen

et al. 2022

Eur J Clin Pharmacol

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Purpose This study aims to compare the effects of ticagrelor and clopidogrel on platelet function, cardiovascular prognosis, and bleeding in patients with unstable angina pectoris. Methods Patients with unstable angina pectoris undergoing percutaneous coronary intervention (PCI) were enrolled (January 2018–December 2019). In total, 212 patients were treated with ticagrelor (90 mg twice daily) and 210 patients were treated with clopidogrel (75 mg once daily). Thromboelastography and light transmission aggregometry were used to measure the platelet aggregation rate (PAR). High-sensitivity troponin T (hs-TnT), pro-brain natriuretic peptide (NT-proBNP), high-sensitivity C-reactive protein (CRP), and heart-type fatty acid–binding protein (h-FABP) were measured to assess myocardial injury after PCI. Cardiovascular prognosis and bleeding events were evaluated in hospital and 12 months after discharge. Results The PAR was significantly slower with ticagrelor (P < 0.001). hs-TnT, NT-proBNP, CRP, and h-FABP increased after compared with before PCI in both groups (P < 0.05). hs-TnT (P < 0.001) and h-FABP (P < 0.001) increased more significantly with clopidogrel. The in-hospital and 12-month major adverse cardiovascular event (MACE) rates were not significantly different between the two groups. The in-hospital total bleeding event rate was higher with ticagrelor (P < 0.05). Minor bleeding and total bleeding were more frequent at the 12-month follow-up in the ticagrelor group (P < 0.05). Conclusion Ticagrelor was more effective in suppressing the PAR than clopidogrel and reduced PCI-induced myocardial injury in patients with unstable angina pectoris. However, it increased in-hospital and 12-month bleeding events and had no benefit on in-hospital and 12-month MACEs.

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Section: Discussionmentioning

confidence: 99%

Comparison of ticagrelor and clopidogrel on platelet function and prognosis in unstable angina

Liu

Chen

et al. 2022

Eur J Clin Pharmacol

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“…h-FABP is a low-molecular-weight protein (14.5 kDa) comprised of 132-amino acid residues found in cardiomyocytes [15]. Like CK-MB and cTnI, h-FABP is released rapidly into the bloodstream when these cells are damaged by acute ischemia [16, 17]. However, in our study, we found no significant changes in the levels of h-FABP, in contrast to increased CK-MB and cTnI after PCI.…”

Section: Discussionmentioning

confidence: 99%

Effects of Trimetazidine Pretreatment on Endothelial Dysfunction and Myocardial Injury in Unstable Angina Patients Undergoing Percutaneous Coronary Intervention

Shao

Shi

Tse

et al. 2019

Cardiology Research and Practice

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Objectives. Trimetazidine is an anti-ischemic medication licensed for the treatment of angina pectoris. However, the molecular mechanisms underlying its action remain incompletely elucidated. In this study, therefore, we examined the potential beneficial effects of trimetazidine on myocardial injury and endothelial dysfunction in patients with unstable angina in the perioperative period of percutaneous coronary intervention (PCI). Methods. A total of 97 patients with unstable angina were randomly divided into trimetazidine (n = 48) and control (n = 49) groups. All subjects received standard medical therapy. The trimetazidine group additionally received 20 mg trimetazidine three times daily 24 hours before and after PCI. Serum levels of creatine kinase-muscle/brain (CK-MB), cardiac troponin I (cTnI), heart-type fatty acid-binding protein (h-FABP), von Willebrand factor (vWF), and nitric oxide (NO) were measured before and the morning following PCI. Results. In the control group, levels of CK-MB, cTnI, and vWF were significantly elevated (P<0.05) and NO level was decreased after PCI (P<0.05). By contrast, no significant changes in the levels of these proteins were observed in the trimetazidine group after PCI (P>0.05). Moreover, h-FABP levels were not significantly altered after PCI whether in the control or in the trimetazidine group (P>0.05). Finally, a time-dependent increase in the levels of h-FABP from 0 to 6 hours after PCI, followed by a progressive decline, was observed (P<0.05). Conclusions. PCI induces endothelial dysfunction and myocardial damage in patients with unstable angina. Trimetazidine therapy in the perioperative period can reduce this damage.

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“…H-FABP can be used to determine myocardial infarct size in patients with ST-segment elevation myocardial infarction (STEMI) and to evaluate their cardiovascular prognoses. Studies have shown that the increased levels of hs-TnT and h-FABP after PCI are significantly lower with ticagrelor administration than with clopidogrel administration, thus proving the myocardial protective effect of ticagrelor [ 50 ]. Compared to clopidogrel, pretreatment with a loading dose of ticagrelor can significantly reduce the incidence of perioperative MI associated with PCI.…”

Section: Clinical Efficacy Of Ticagrelor In Disease Treatmentmentioning

confidence: 99%

Progress in the clinical effects and adverse reactions of ticagrelor

Wei,

Wang,

et al. 2024

Thrombosis J

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Background Ticagrelor is a novel receptor antagonist that selectively binds to the P2Y12 receptor, thereby inhibiting adenosine diphosphate (ADP)-mediated platelet aggregation. Compared to clopidogrel, ticagrelor has the advantages of a fast onset, potent effects, and a reversible platelet inhibition function, which make this drug clinically suitable for treating acute coronary syndrome (ACS), especially acute ST-segment elevation myocardial infarction (STEMI). Objective This review was performed to determine the basic characteristics, clinical effects, and adverse reactions of ticagrelor. Methods Relevant trials and reports were obtained from the MEDLINE, Embase, and Cochrane Library databases. Results Ticagrelor is rapidly absorbed by the body after oral administration, exhibits inherent activity without requiring metabolic activation, and binds reversibly to the P2Y12 receptor. Ticagrelor has been recommended in ACS treatment guidelines worldwide due to its advantageous pharmacological properties and significant clinical benefits. Ticagrelor inhibits platelet aggregation, inhibits inflammatory response, enhances adenosine function, and has cardioprotective effects. However, ticagrelor also causes adverse reactions such as bleeding tendency, dyspnea, ventricular pause, gout, kidney damage, and thrombotic thrombocytopenic purpura in clinical treatment. Therefore, it is necessary to pay attention to risk assessments when using ticagrelor. Conclusion Ticagrelor is a promising drug for the effective treatment of ACS. When using ticagrelor, individualized treatment should be provided based on the specific conditions of the patients to avoid serious adverse events.

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Role of Cardiac Myocytes Heart Fatty Acid Binding Protein Depletion (H-FABP) in Early Myocardial Infarction in Human Heart (Autopsy Study)

Cited by 10 publications

References 12 publications

Comparison of ticagrelor and clopidogrel on platelet function and prognosis in unstable angina

Comparison of ticagrelor and clopidogrel on platelet function and prognosis in unstable angina

Effects of Trimetazidine Pretreatment on Endothelial Dysfunction and Myocardial Injury in Unstable Angina Patients Undergoing Percutaneous Coronary Intervention

Progress in the clinical effects and adverse reactions of ticagrelor

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