A comparative study of grape seed extract and vitamin E effects on silica-induced pulmonary fibrosis in rats

Hemmati, Ali Asghar; Nazari, Zahra; Samei, Mehdi

doi:10.1016/j.pupt.2008.04.004

Cited by 51 publications

(28 citation statements)

References 25 publications

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“…In another study, 7,12-dimethylobenz[a]anthracene (a tumour factor) caused significant decrease in CAT and GPX activity, but after addition of the novel synthetic organoselenium compounds to the diet, the activity of both enzymes strongly increased, which was ascribed to strong nucleophilic (and henceantioxidant) properties of such compounds [18]. On the other hand, previous data on grape seed extract, containing natural antioxidants, used to ameliorate the fibrogenic effect of silica, suggest that dietary factors may also play an important role in the prevention of lungs against oxidative stress [23]. Grape seeds, similarly to quinoa studied in the present work, are rich in antioxidant phytochemicals, mainly phenolic compounds, and flavanols.…”

Section: Discussionmentioning

confidence: 95%

Effect of Diet Supplemented with Quinoa Seeds on Oxidative Status in Plasma and Selected Tissues of High Fructose-Fed Rats

Paśko

Bartoń

Zagrodzki

et al. 2010

Plant Foods Hum Nutr

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Oxidative stress plays an important role as a mediator of damage produced by fructose metabolism. This work was designed to investigate the effect of diet supplemented with quinoa seeds on oxidative stress in plasma, heart, kidney, liver, spleen, lung, testis and pancreas of fructose administered rats. Fructose administration (310 g/kg fodder for 5 weeks) caused oxidative stress that was manifested by the increase in plasma malondialdehyde (MDA) (p<0.05), and by the non-significant changes in the enzymatic antioxidant potential in plasma and most of tissues. Co-administration of quinoa seeds (310 g/kg fodder) maintained normal activities of some enzymes. It also influenced the oxidative stress as was evidenced by decreasing MDA in plasma, and decreasing the activities of antioxidant enzymes (erythrocyte superoxide dismutase - eSOD, catalase -CAT, plasma glutathione peroxidase - pGPX). These findings demonstrate that quinoa seeds can act as a moderate protective agent against potential of fructose-induced changes in rats by reducing lipid peroxidation and by enhancing the antioxidant capacity of blood (plasma) and heart, kidney, testis, lung and pancreas.

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Section: Discussionmentioning

confidence: 95%

Effect of Diet Supplemented with Quinoa Seeds on Oxidative Status in Plasma and Selected Tissues of High Fructose-Fed Rats

Paśko

Bartoń

Zagrodzki

et al. 2010

Plant Foods Hum Nutr

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“…Also, the mechanism for the hepatoprotective effects of PAC in the development of liver fibrosis may be related to the reduction of lipid peroxidation by its antioxidative activity (Shin et al 2010). Moreover, it can exert its effect by scavenging ROS (Hemmati et al 2008).…”

Section: Discussionmentioning

confidence: 99%

Proanthocyanidin as a cytogenetic protective agent against adverse effects of plant growth regulators supplementation in rats

2013

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The aim of the present study was to investigate the protective role of grape seed extract (containing proanthocyandin) against the adverse effects of plant growth regulators (GA 3 (gibberellic acid) and IAA (indoleacetic acid)). The present data showed that the administration of either GA 3 and IAA caused undesirable changes in both hepatic and testicular structure. This was evidenced by a disturbed hepatic strands, pyknotic nuclei, central vein with collapsed endothelium, dilatation in bile sinusoids, congested blood vessel, binucleatd hepatocytes, lymphocytic infiltration, vacuolation, giant hepatic cells, increased Kupffer cells and karyoryxis. Additionally, it was shown that degenerative changes in the testis, spermatogenic arrest, moderate tubular necrosis, Leydig cell degeneration and reduction in the number and size of the seminiferous tubules with some spermatogonia detached from the basement membrane. Concerning flow cytometric study of the liver a significant decrease in G0/1 % and a significant increase in S phase %, G2/ M %, P 53 % and apoptosis % (sub G1) were detected. However, in testis the data recorded a significant decrease in the percentage of mature sperm (percentage of haploid cells) and a significant increase in the percentage of spermatide, diploid cells, P 53 and of apoptotic cells. On the other hand, a distinct recovery of the mentioned hepatic and testicular histopathological and cytogenetic disorders was observed when proanthocyanidin was supplemented to rats administered either of the plant growth hormones (GA 3 and IAA).

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“…The first group was kept on saline and served as control. The second group was orally (16 G ball-tipped feeding needle with syringe) administered 150 mg/kg/day GSE for 30 days 21 and served as GSE group. The third group was injected subcutaneously with 50 mg/kg GM twice daily for 15 days 1,22 and served as GM group.…”

Section: Experimental Designmentioning

confidence: 99%

Renoprotective Effect of Grape Seed Extract against Oxidative Stress Induced by Gentamicin and Hypercholesterolemia in Rats

Salem

2011

Renal Failure

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Rationale: Kidneys are dynamic organs and represent one of the major systems maintaining the body homeostasis; they are affected by many chemicals and drugs. Grape seed extract (GSE) has been targeted to prevent drug-induced renal toxicity. Objectives: This study investigates the possible renoprotective effect of GSE against oxidative stress, renal impairment, and hypercholesterolemia (HC) induced by gentamicin (GM) and cholesterol-enriched diet. Seventy adult male Wistar rats (160 ± 10 g) were divided into seven groups: (1) served as control, (2) GSE, (3) GM, (4) GSE + GM, (5) hypercholesterolemic (HC) group, (6) GM + HC group, and (7) GM + HC + GSE. Kidney functions, inflammatory mediators, cytokines, lipid profile, nitric oxide (NO), cyclic guanosine monophosphate (cGMP), and oxidative and antioxidative stress parameters were assessed in all groups. Main findings: GM induced renal dysfunction, which was exacerbated by the presence of HC as confirmed by laboratory determinations. Administration of GSE attenuated the renal toxicity evidenced in significant reduction in elevated kidney function, inflammatory cytokines as well as lipid profile, NO, cGMP, enzymatic, and nonenzymatic antioxidants. Conclusion: Administration of GSE simultaneously with GM attenuated oxidative stress, diminished renal toxicity, and improved lipid profile induced by GM and HC.

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A comparative study of grape seed extract and vitamin E effects on silica-induced pulmonary fibrosis in rats

Cited by 51 publications

References 25 publications

Effect of Diet Supplemented with Quinoa Seeds on Oxidative Status in Plasma and Selected Tissues of High Fructose-Fed Rats

Effect of Diet Supplemented with Quinoa Seeds on Oxidative Status in Plasma and Selected Tissues of High Fructose-Fed Rats

Proanthocyanidin as a cytogenetic protective agent against adverse effects of plant growth regulators supplementation in rats

Renoprotective Effect of Grape Seed Extract against Oxidative Stress Induced by Gentamicin and Hypercholesterolemia in Rats

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