A Comparative Study of Early Bone Formation with PRF, Bio-Oss and Osteoid Hydroxyapatite after Tooth Extraction in Rabbits

Abstract

The objective of this study was to compare the ability of platelet-rich fibrin (PRF), Bio-Oss and osteoid hydroxyapatite (OHA) in early bone formation by filling tooth extraction sockets in rabbits. 48 rabbits were randomly divided into 4 groups: group A (PRF), group B (Bio-Oss), group C (OHA), and group D (control). One of the mandibular central incisors was extracted and instantly filled with graft materials. General, radiological and histological observations were evaluated 1, 2, 3, 4, 6, and 8 weeks later. In the first 4 weeks, the quantity of new bone in the PRF group alveolar defects was the best, and the bone mineral density was significantly higher. At the 6 th and 8 th weeks, the speed of new bone formation in the Bio-Oss group and the OHA group was better than that in the PRF group. Compared with the Bio-Oss group, the OHA group had osteoblasts which were more active and a slightly larger number of bone trabeculae. In addition, the control group was worse than other groups in bone-formation. These results indicate that PRF, OHA and Bio-Oss all can promote osteogenesis in tooth extraction sockets, but the effect of PRF is remarkable at the early time of bone formation. At the later stage, both Bio-Oss and OHA can repair bone defects and guide bone regeneration, and the potential bone formation ability of OHA is better.

Evaluation of the Effect of Platelet Rich Fibrin on Alveolar Socket Healing in Glucocorticoids-Induced Osteoporosis in Rabbits (Histological and Immuno-histomorphometric study)

“…These histological findings was in agree with investigator (37) who found that PRF has an osteo-promotive activity since it contains a high concentration of growth factors, such as transforming growth factor -beta 1,2 and vascular endothelial growth factor. These growth factors promote regeneration of blood vessel as well as proliferation and migration of osteoblasts.…”

Flapless osteotome‐mediated sinus floor elevation using platelet‐rich fibrin versus lateral approach using deproteinised bovine bone mineral for residual bone height of 2–6 mm: A randomised trial

“…Various growth factors, such as transforming growth factor‐β and vascular endothelial growth factor, are present inside fibrin clots. Thus, PRF appears to have osteoinductive and osteoconductive properties, which may significantly promote bone augmentation (Choukroun et al, 2006; Pei et al, 2015; Troedhan et al, 2015).…”

“…Thus, PRF appears to have osteoinductive and osteoconductive properties, which may significantly promote bone augmentation (Choukroun et al, 2006;Pei et al, 2015;Troedhan et al, 2015).…”

The endoscopically assisted transcrestal sinus floor elevation with platelet-rich fibrin at an immediate implantation of periapical lesion site

“…[7] Platelet-rich fibrin (PRF) has a 3D fibrin scaffold structure that is rich in platelets and various cytokines, which can effectively promote the regeneration of soft and hard tissues and control the inflammatory reaction. [8,9] The use of PRF as the only filling material can effectively promote bone regeneration in the case of sinus floor elevation. [10,11]…”