A comparative study of different β-whiUockite ceramics in rabbit cortical bone with regard to their biodegradation behaviour

Klein, Gerhart P.; Groot, K. de; Driessen, A. A.; Lübbe, H

doi:10.1016/0142-9612(86)90072-4

Cited by 66 publications

(23 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the case of ZnTCP and MgTCP, the specimens had the same porosity and different equilibrium solubility while, in the case of pure TCP, the specimens had the same solubility and different porosity. Regarding microporosity of TCP, it is reported that an increase in the microporosity of TCP has a greater effect on resorption than an increase in macroporosity [3,39,40]. These phenomena are qualitatively similar to the effect of microporosity and macroporosity on the dissolution rates.…”

Section: Discussionsupporting

confidence: 69%

Interlaboratory studies on in vitro test methods for estimating in vivo resorption of calcium phosphate ceramics

et al. 2015

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 69%

Interlaboratory studies on in vitro test methods for estimating in vivo resorption of calcium phosphate ceramics

et al. 2015

View full text Add to dashboard Cite

“…We expected that ␤-TCP would be degraded and absorbed because it is known to be biodegradable. 34,35 Indeed, even large particles on the TCPC surface were severely degraded and absorbed 10 weeks after implantation in this study. By contrast, there have been reports indicating that HA is both bioinert 36,37 and subject to biodegradation.…”

Section: Discussionmentioning

confidence: 90%

Bioactive bone cement: Comparison of apatite and wollastonite containing glass-ceramic, hydroxyapatite, and ?-tricalcium phosphate fillers on bone-bonding strength

Kobayashi

Nakamura

Okada

et al. 1998

J. Biomed. Mater. Res.

View full text Add to dashboard Cite

A study was conducted to compare the bone-bonding strengths of three types of bioactive bone cement, consisting of either apatite- and wollastonite-containing glass-ceramic (AW-GC) powder, hydroxyapatite (HA) powder, or beta-tricalcium phosphate (beta-TCP) powder as an inorganic filler and bisphenol-a-glycidyl methacrylate (Bis-GMA) based resin as an organic matrix. Seventy percent (w/w) filler was added to the cement. Rectangular plates (10 x 15 x 2 mm) of each cement were made and abraded with #2000 alumina powder. After soaking in simulated body fluid for 2 days, the AW cement (AWC) and HA cement (HAC) formed bonelike apatite over their entire surfaces, but the TCP cement (TCPC) did not. Plates of each type of cement were implanted into the tibial metaphyses of male Japanese white rabbits, and the failure loads were measured by a detaching test at 10 and 25 weeks after implantation. The failure loads of AWC, HAC, and TCPC were 3.95, 2.04, and 2.03 kgf at 10 weeks and 4.36, 3.45, and 3.10 kgf at 25 weeks, respectively. The failure loads of the AWC were significantly higher than those of the HAC and TCPC at 10 and 25 weeks. Histological examination by contact microradiogram and Giemsa surface staining of the bone-cement interface revealed that all the bioactive bone cements were in direct contact with bone. However, scanning electron microscopy and energy-dispersive X-ray microanalysis showed that only AWC had contacted to the bone via a Ca-P rich layer formed at the interface between the AW-GC powder and the bone, which might explain its high bone-bonding strength. Neither the HAC nor the TCPC contacted the bone through such a layer between each powder and the bone, although the HAC and TCPC directly contacted with bone. Our results indicate that all three types of abraded and prefabricated cement have bonding strength to bone, but AWC has superior bone-bonding strength compared to HAC and TCPC.

show abstract

“…The deficiency of Mg in bone has been suggested as a possible risk factor for osteoporosis in humans (11). Mg is known to reduce the degradation rate of calcium phosphate biomaterials (18)(19)(20) and to influence the crystallization of mineral substances (12,13,(21)(22)(23)(24)(25)(26)(27). The substituted low-Mg-containing apatite sample decreased the osteoinductive properties of biomaterials, whereas the substituted high-Mg-containing apatite had a toxic effect on bone cells (12).…”

Section: Introductionmentioning

confidence: 99%

Structural Characterization and Biological Fluid Interaction of Sol−Gel-Derived Mg-Substituted Biphasic Calcium Phosphate Ceramics

Gomes

Renaudin

Jallot

et al. 2009

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Sol-Gel chemistry has been used to prepare undoped and Mg-substituted biphasic calcium phosphate (BCP) ceramics composed of hydroxyapatite (HAp) and whitlockite ( -TCP) phases. Different series of samples have been synthesized with different Mg-doping levels (from 0 to 5 atomic % of Ca atoms substituted) and different temperatures of calcination (from 500 to 1100°C). All of the powdered samples were systematically treated by Rietveld refinement to extract the quantitative phase analysis and the structural and microstructural parameters, to locate the Mg crystallographic sites, and to refine the composition of the Mg-substituted phases. The temperature dependence of the weight amount ratio between HAp and -TCP is not monotonic because of the formation of minor phases such as Ca 2 P 2 O 7 , CaO, MgO, and CaCO 3 and certainly an amorphous phase. On the other hand, the Mg stabilizing feature on the -TCP phase has been evidenced and explained. The mechanism of stabilization by small Mg 2+ is different from that by large Sr 2+ . Nevertheless, in both cases, the -TCP stabilization is realized by an improvement of the environment of the Ca4 site unusually face-coordinated to a PO 4 tetrahedron. The substitution of a Mg atom in the Ca5 site allows considerable improvement of the bond valence sum of the unusual Ca4 polyhedron. The temperatures of calcination combined with the amount of Mg atoms introduced allow monitoring of the phase composition of the BCP ceramics as well as their microstructural properties. The bioactivity properties of the BCP samples are improved by the presence of Mg atoms in the structure of the -TCP phase. The mechanism of improvement is mainly attributed to an accelerated kinetic of precipitation of a calcium phosphate layer at the surface comprising HAp and/or -TCP phases.

show abstract

A comparative study of different β-whiUockite ceramics in rabbit cortical bone with regard to their biodegradation behaviour

Cited by 66 publications

References 6 publications

Interlaboratory studies on in vitro test methods for estimating in vivo resorption of calcium phosphate ceramics

Interlaboratory studies on in vitro test methods for estimating in vivo resorption of calcium phosphate ceramics

Bioactive bone cement: Comparison of apatite and wollastonite containing glass-ceramic, hydroxyapatite, and ?-tricalcium phosphate fillers on bone-bonding strength

Structural Characterization and Biological Fluid Interaction of Sol−Gel-Derived Mg-Substituted Biphasic Calcium Phosphate Ceramics

Contact Info

Product

Resources

About