A comparative randomized open label study to evaluate efficacy, safety and cost effectiveness between topical 2% sertaconazole and topical 1% butenafine in tinea infections of skin

Abstract

Background:Dermatophytoses are the superficial fungal infections of skin, hair, and nail. Butenafine is a benzylamine group of antifungal that inhibits the biosynthesis of ergosterol by blocking squalene epoxidase. Sertaconazole is a newer imidazole antifungal which inhibits the biosynthesis of ergosterol by inhibiting 14-α lanosterol demethylase. The study was done to compare a newer antifungal with a relatively older one.Aim:To compare the efficacy, safety and cost effectiveness of topical 2% sertaconazole cream and 1% butenafine in tinea infections of skin.Materials and Methods:Patients were randomly allocated to two treatment groups. They were advised to apply the drug topically twice a day for one month on the lesions. They were followed up at an interval of 10 days. Clinical score and Global Evaluation Response were assessed at baseline and during each follow up.Results:A total 125 patients were recruited, out of them 111 completed the whole study. Median Sign and Symptom Score of tinea on the baseline was 9 [5,9] that was reduced to 0 [0,4] by 2% sertaconazole while it was 9 [6,9] in the butenafine group on the baseline that was reduced to 0 [0,6] at the end of the treatment. 98% and 90% of the patients got complete clearance of the lesions with butenafine and sertaconazole, respectively. Treatment with butenafine was more cost effective as compared to sertaconazole.Conclusion:1% butenafine is more efficacious, cost effective, and equally safe as compared to 2% sertaconazole in the tinea infections of skin.

Efficacy and tolerability of topical sertaconazole versus topical terbinafine in localized dermatophytosis: A randomized, observer-blind, parallel group study

“…The absence of significant differences between the two is possibly due to the unique fungicidal action of sertaconazole which includes direct fungal cell membrane damage and subsequent leakage of intracellular contents. [2021]…”

To Compare the Efficacy of Once a Day Versus Twice Daily Application of Amorolfine 0.25% Cream- A Single-Blinded, Randomized, Control Study

“…The present study and other studies have noted that dermatophytosis is mostly the disease of younger age. [9,10] Males were more affected than females, i.e. group A 22 (73.33%) and Group B 19 (63.33%), which may be due to outdoor working conditions.…”

“…Current study and most of the other studies had similar observation, which overall noted that dermatophytosis infects young population, males outnumber females, and tinea corporis is more common than cruris. [9,10,11,12] Global assessment of patients in Table 2 indicates response rate was more in group B from beginning to end. After 6 weeks (3 rd visit), clinical and mycological cure was 24 (80%) patients in group A, while it was 26 (86.67%) in Group B.…”

Comparison of Efficacy and Safety of Topical 1% Butenafine and Topical 1% Ciclopirox Olamine in the Treatment of Tinea Pedis and Evaluation of the Effects on the Quality of Life of These Treatmens: A Randomized Single-Blind Trial

“…Thaker et al (8) have compared topical sertaconazole and butenafine in the skin tinea infections and have found significant decrease in the scores of signs and symptoms. However, the higher improvement has been obtained with butenafine therapy according to Global Evaluation Response scores.…”