This paper presents a practical solution to a problem facing high-fan-in, high-bandwidth synchronized TCP workloads in datacenter Ethernets-the TCP incast problem. In these networks, receivers can experience a drastic reduction in application throughput when simultaneously requesting data from many servers using TCP. Inbound data overfills small switch buffers, leading to TCP timeouts lasting hundreds of milliseconds. For many datacenter workloads that have a barrier synchronization requirement (e.g., filesystem reads and parallel data-intensive queries), throughput is reduced by up to 90%. For latency-sensitive applications, TCP timeouts in the datacenter impose delays of hundreds of milliseconds in networks with round-trip-times in microseconds.Our practical solution uses high-resolution timers to enable microsecond-granularity TCP timeouts. We demonstrate that this technique is effective in avoiding TCP incast collapse in simulation and in real-world experiments. We show that eliminating the minimum retransmission timeout bound is safe for all environments, including the wide-area.

We study the feasibility of extending the lifetime of a wireless sensor network by exploiting mobility. In our system, a small percentage of network nodes are autonomously mobile, allowing them to move in search of energy, recharge, and deliver energy to immobile, energy-depleted nodes. We term this approach energy harvesting. We characterize the problem of uneven energy consumption, suggest energy harvesting as a possible solution, and provide a simple analytical framework to evaluate energy consumption and our scheme. Data from initial feasibility experiments using energy harvesting show promising results.

This paper presents a practical solution to a problem facing high-fan-in, high-bandwidth synchronized TCP workloads in datacenter Ethernets-the TCP incast problem. In these networks, receivers can experience a drastic reduction in application throughput when simultaneously requesting data from many servers using TCP. Inbound data overfills small switch buffers, leading to TCP timeouts lasting hundreds of milliseconds. For many datacenter workloads that have a barrier synchronization requirement (e.g., filesystem reads and parallel data-intensive queries), throughput is reduced by up to 90%. For latency-sensitive applications, TCP timeouts in the datacenter impose delays of hundreds of milliseconds in networks with round-trip-times in microseconds.Our practical solution uses high-resolution timers to enable microsecond-granularity TCP timeouts. We demonstrate that this technique is effective in avoiding TCP incast collapse in simulation and in real-world experiments. We show that eliminating the minimum retransmission timeout bound is safe for all environments, including the wide-area.

Despite significant advances in standard of care therapies, the 5-year survival rate for metastatic colorectal cancer (CRC) remains around 12%. Immunotherapy has not provided the stellar advances in colorectal cancer that has been seen in other malignancies. Immunotherapy appears to play a pivotal role in microsatellite unstable CRC tumors where the response rates are profound. These results have led to FDA approval of pembrolizumab for MSI-H CRC tumors. Additional research into several new immune agents including IDO inhibitors, vaccine therapy and combinatorial agents are being evaluated for CRC. This review will provide an overview of the approaches currently being investigated.

Background:Periorbital hyperpigmentation (POH) is one of the most commonly encountered conditions in routine dermatology practice. There are only few published studies about its prevalence, classification, and pathogenesis but none showing its association with habits, and other medical conditions in Indian patients.Aims:To determine prevalence and type of POH, common causative factors, and its association with personal habits and other disorders within various age and sex groups.Materials and Methods:Two hundred patients attending the dermatology OPD were included in study and were subjected to detailed history, careful clinical and Wood's lamp examination, eyelid stretch test and laboratory investigations. Clinical photographs of all patients were taken.Results:POH was most prevalent in 16-25 years age group (47.50%) and in females (81%) of which majority were housewives (45.50%). Commonest form of POH was constitutional (51.50%) followed by post inflammatory (22.50%). Lower eyelids were involved in 72.50%. Grade 2 POH was seen in 58%. Wood's lamp examination showed POH to be dermal in 60.50%. Faulty habits were observed viz. lack of adequate sleep (40%), frequent cosmetic use (36.50%), frequent eye rubbing (32.50%), and lack of correction for errors of refraction like myopia in 12% patients. Strong association of POH with stress (71%), atopy (33%) and family history (63%) was noted.Conclusions:Periorbital hyperpigmentation is a multi-factorial entity. It is absolutely essential to classify the type of POH and determine underlying causative factors in order to direct appropriate measures for better and successful outcome in future.