A Comparative Pilot Study of Two Dental Implant Metals in a Pig Model

Rodella, Luigi Fabrizio; Favero, Gaia; Sala, Lorenzo; Buffoli, Barbara; Castelli, Giovanni; Belloni, Vincenzo; Paganelli, Corrado; Rezzani, Rita

doi:10.1097/id.0b013e318200301a

Cited by 4 publications

(3 citation statements)

References 24 publications

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“…49,50 Our study found that several methods were used to evaluate bone deposition on implant surfaces, and the most prevalent were histological and histomorphometric analyses. 34,36,40,51 These are effective techniques in analyzing bone-implant contact, which is considered the primary outcome in studies evaluating the osseointegration of dental implants. All the presented methods are well-grounded in the literature and have their peculiarities in terms of assessing peri-implant bone formation.…”

Section: Discussionmentioning

confidence: 99%

Dental implants in large animal models with experimental systemic diseases: A systematic review

et al. 2023

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This systematic review aims to identify and discuss the most used methodologies in pre-clinical studies for the evaluation of the implementation of dental implants in systemically compromised pigs and sheep. This study provides support and guidance for future research, as well as for the prevention of unnecessary animal wastage and sacrifice. Preferred Reporting for Systematic Reviews and Meta-Analyses (PRISMA) was used as a guideline; electronic searches were performed in PubMed, Scopus, Scielo, Web of Science, Embase, Science Direct, Brazilian Bibliography of Dentistry, Latin American and Caribbean Literature in Health Sciences, Directory of Open Access Journals, Database of Abstracts of Reviews of Effects, and gray literature until January 2022 (PROSPERO/CRD42021270119). Sixty-eight articles were chosen from the 2439 results. Most studies were conducted in pigs, mainly the Göttinger and Domesticus breeds. Healthy animals with implants installed in the jaws were predominant among the pig studies. Of the studies evaluating the effect of systemic diseases on osseointegration, 42% were performed in osteoporotic sheep, 32% in diabetic sheep, and 26% in diabetic pigs. Osteoporosis was primarily induced by bilateral ovariectomy and mainly assessed by X-ray densitometry. Diabetes was induced predominantly by intravenous streptozotocin and was confirmed by blood glucose analysis. Histological and histomorphometric analyses were the most frequently employed in the evaluation of osseointegration. The animal models presented unique methodologies for each species in the studies that evaluated dental implants in the context of systemic diseases. Understanding the most commonly used techniques will help methodological choices and the performance of future studies in implantology.

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Section: Discussionmentioning

confidence: 99%

Dental implants in large animal models with experimental systemic diseases: A systematic review

et al. 2023

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“…Notably, 3 to 4 implants can be anchored per quadrant [ 284 ] with human or human-like implants 4 mm in diameter and 11 mm in length [ 286 ]. As for the tibia, the oral model may be useful for histological analyses such as cytotoxicity and viability of new compositions [ 287 , 288 , 289 , 290 ] but also for assessments on 1:1 scale models of mechanical properties [ 47 , 268 , 291 ], stress distribution [ 287 , 288 ], and the effects of different implant and abutment shapes [ 264 , 284 , 292 , 293 , 294 , 295 ]. Thanks to pigs having similar bone properties to those of humans, resistance to insertion [ 273 ] or removal torque can be measured during [ 296 ] or after healing [ 268 ].…”

Section: Appendix A1 Research In Non-human Primatesmentioning

confidence: 99%

“…It is possible to perform classical analysis such as measurement of bone area [ 273 ], marginal bone level [ 273 ], crestal bone loss [ 275 ], , resonance frequency [ 273 ], or implant stability quotient [ 297 ]. However, the main reason for selecting this site is almost always its suitability for bone-to-implant contact analysis [ 273 , 281 , 282 , 286 , 289 , 290 , 294 ]. This model is also used to assess the accuracy of new techniques, such as ultrasound imaging [ 298 ], comparison of intra-oral and cone beam computed tomography [ 299 , 300 ], magnetic resonance imaging [ 301 ], and resonance frequency analysis [ 302 ].…”

Section: Appendix A1 Research In Non-human Primatesmentioning

confidence: 99%

Pre-Clinical Models in Implant Dentistry: Past, Present, Future

et al. 2021

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Biomedical research seeks to generate experimental results for translation to clinical settings. In order to improve the transition from bench to bedside, researchers must draw justifiable conclusions based on data from an appropriate model. Animal testing, as a prerequisite to human clinical exposure, is performed in a range of species, from laboratory mice to larger animals (such as dogs or non-human primates). Minipigs appear to be the animal of choice for studying bone surgery around intraoral dental implants. Dog models, well-known in the field of dental implant research, tend now to be used for studies conducted under compromised oral conditions (biofilm). Regarding small animal models, research studies mostly use rodents, with interest in rabbit models declining. Mouse models remain a reference for genetic studies. On the other hand, over the last decade, scientific advances and government guidelines have led to the replacement, reduction, and refinement of the use of all animal models in dental implant research. In new development strategies, some in vivo experiments are being progressively replaced by in vitro or biomaterial approaches. In this review, we summarize the key information on the animal models currently available for dental implant research and highlight (i) the pros and cons of each type, (ii) new levels of decisional procedures regarding study objectives, and (iii) the outlook for animal research, discussing possible non-animal options.

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TiNOx coatings on roughened titanium and CoCr alloy accelerate early osseointegration of dental implants in minipigs

Durual

Rieder

Garavaglia

et al. 2013

Bone

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A Comparative Pilot Study of Two Dental Implant Metals in a Pig Model

Abstract: This study revealed no significant short-term difference between the use of titanium and a chrome-cobalt alloy in implant effectiveness in the process of osseointegration.

Cited by 4 publications

References 24 publications

Dental implants in large animal models with experimental systemic diseases: A systematic review

Dental implants in large animal models with experimental systemic diseases: A systematic review

Pre-Clinical Models in Implant Dentistry: Past, Present, Future

TiNOx coatings on roughened titanium and CoCr alloy accelerate early osseointegration of dental implants in minipigs

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