TiNOx coatings on roughened titanium and CoCr alloy accelerate early osseointegration of dental implants in minipigs

Durual, Stéphane; Rieder, Peter; Garavaglia, Giovanni; Filieri, Anna-Rita Musardo; Cattani-Lorente, Maria Angeles; Scherrer, Susanne S.; Wiskott, Anselm

doi:10.1016/j.bone.2012.09.014

Cited by 25 publications

(21 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, we have used an animal model to evaluate bone response to Ti implants and no significant differences in terms of histological and histomorphometric parameters were observed when plasma-nitrided surfaces were compared with untreated one. In agreement with this, it has been shown that, despite modifying surface characteristics, bone formation in close contact with Ti implants is not deeply affected by nitriding treatments 9 , 15 , 24 . Bone contact, area, and volume were not affected by nitride Ti produced by powder immersion reaction assisted coating when implanted in rat femora for 8 weeks 24 .…”

Section: Discussionsupporting

confidence: 68%

“…Nitrided Ti surfaces produced by glow-discharge plasma treatment had no effect on bone contact and area when implanted in rabbit tibia for 1, 3, and 6 weeks 15 . On the other hand, the increased bone contact with nitrided Ti surface produced by plasma vapor observed 2 weeks post-implantation decreased after 1 and 3 months 9 . As our evaluation was carried out at 6 weeks, a period in which the process of bone formation is completed in this animal model 12 , it is possible to suggest that some effect of plama-nitrided Ti implant surfaces on bone formation, if any, could be noticed in early time-points.…”

Section: Discussionmentioning

confidence: 87%

See 1 more Smart Citation

Bone tissue response to plasma-nitrided titanium implant surfaces

et al. 2015

View full text Add to dashboard Cite

A current goal of dental implant research is the development of titanium (Ti) surfaces to improve osseointegration. Plasma nitriding treatments generate surfaces that favor osteoblast differentiation, a key event to the process of osteogenesis. Based on this, it is possible to hypothesize that plasma-nitrided Ti implants may positively impact osseointegration. Objective The aim of this study was to evaluate the in vivo bone response to Ti surfaces modified by plasma-nitriding treatments.Material and Methods Surface treatments consisted of 20% N2 and 80% H2, 450°C and 1.5 mbar during 1 h for planar and 3 h for hollow cathode. Untreated surface was used as control. Ten implants of each surface were placed into rabbit tibiae and 6 weeks post-implantation they were harvested for histological and histomorphometric analyses.Results Bone formation was observed in contact with all implants without statistically significant differences among the evaluated surfaces in terms of bone-to-implant contact, bone area between threads, and bone area within the mirror area.Conclusion Our results indicate that plasma nitriding treatments generate Ti implants that induce similar bone response to the untreated ones. Thus, as these treatments improve the physico-chemical properties of Ti without affecting its biocompatibility, they could be combined with modifications that favor bone formation in order to develop new implant surfaces.

show abstract

Section: Discussionsupporting

confidence: 68%

Section: Discussionmentioning

confidence: 87%

Bone tissue response to plasma-nitrided titanium implant surfaces

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Hence patient safety must be assured using biocompatibility testing. The cell lines (hOBs and the 3T3 cells) cultured for the biocompatibility assays are standard well established cell lines commonly used for the biocompatibility evaluation of materials in our laboratory 15,16,25) . Biocompatibility assays revealed relatively good cell proliferations of both types of cells cultured, hOBs as well as the 3T3 cells, on both the resin substrates.…”

Section: Discussionmentioning

confidence: 99%

CAD/CAM milled complete removable dental prostheses: An <i>in vitro</i> evaluation of biocompatibility, mechanical properties, and surface roughness

Srinivasan

Gjengedal

Cattani-Lorente

et al. 2018

Dental Materials Journal

Self Cite

112

124

View full text Add to dashboard Cite

This study compared the biocompatibility, mechanical properties, and surface roughness of a pre-polymerized polymethyl methacrylate (PMMA) resin for CAD/CAM complete removable dental prostheses (CRDPs) and a traditional heat-polymerized PMMA resin. Two groups of resin substrates [Control (RC): conventional PMMA; Test (RA): CAD/CAM PMMA] were fabricated. Human primary osteoblasts and mouse embryonic-fibroblasts were cultured for biocompatibility assays. Mechanical properties and surface roughness were compared. ANOVA revealed no difference between the resin groups in the biocompatibility assays. RA demonstrated a higher elastic modulus (p=0.002), young's modulus (p=0.002), plastic energy (p=0.002), ultimate strength (p=0.0004), yield point (p=0.016), strain at yield point (p=0.037), and toughness (p<0.0001); while RC displayed a higher elastic energy (p<0.0001). Laser profilometry concluded a rougher surface profile (p<0.0001) for RA. This study concluded that the tested CAD/CAM resin was equally biocompatible and presented with improved mechanical properties than the traditional heat-polymerized PMMA resin used in the fabrication of CRDPs.

show abstract

“…In the literature, there are several reports on the biological reactions at TiN surfaces, mainly prepared by PVD and CVD techniques, including the responses of bone [42–44], soft tissues [42, 45] blood [16, 17, 46, 47], platelets [48], human mesenchymal stem cells [49], and osteoblasts [50, 51]. Several of those studies indicate that TiN surfaces have beneficial or comparable properties in comparison with other currently and frequently used materials.…”

Section: Discussionmentioning

confidence: 99%

Bone Response to Surface-Modified Titanium Implants: Studies on the Early Tissue Response to Implants with Different Surface Characteristics

Wexell

Thomsen

Aronsson

et al. 2013

International Journal of Biomaterials

View full text Add to dashboard Cite

In a series of experimental studies, the bone formation around systematically modified titanium implants is analyzed. In the present study, three different surface modifications were prepared and evaluated. Glow-discharge cleaning and oxidizing resulted in a highly stoichiometric TiO2 surface, while a glow-discharge treatment in nitrogen gas resulted in implants with essentially a surface of titanium nitride, covered with a very thin titanium oxide. Finally, hydrogen peroxide treatment of implants resulted in an almost stoichiometric TiO2, rich in hydroxyl groups on the surface. Machined commercially pure titanium implants served as controls. Scanning Auger Electron Spectroscopy, Scanning Electron Microscopy, and Atomic Force Microscopy revealed no significant differences in oxide thickness or surface roughness parameters, but differences in the surface chemical composition and apparent topography were observed. After surface preparation, the implants were inserted in cortical bone of rabbits and evaluated after 1, 3, and 6 weeks. Light microscopic evaluation of the tissue response showed that all implants were in contact with bone and had a large proportion of newly formed bone within the threads after 6 weeks. There were no morphological differences between the four groups. Our study shows that a high degree of bone contact and bone formation can be achieved with titanium implants of different surface composition and topography.

show abstract

TiNOx coatings on roughened titanium and CoCr alloy accelerate early osseointegration of dental implants in minipigs

Cited by 25 publications

References 36 publications

Bone tissue response to plasma-nitrided titanium implant surfaces

Bone tissue response to plasma-nitrided titanium implant surfaces

CAD/CAM milled complete removable dental prostheses: An <i>in vitro</i> evaluation of biocompatibility, mechanical properties, and surface roughness

Bone Response to Surface-Modified Titanium Implants: Studies on the Early Tissue Response to Implants with Different Surface Characteristics

Contact Info

Product

Resources

About