A comparative analysis of langerhans cell in oral epithelial dysplasia and oral squamous cell carcinoma using antibody CD-1a

Abstract

The present study suggests that there is a recruitment of LCs in the neoplastic process. Changes observed in LC distribution within the zones of dysplastic epithelium and tumor stroma can be interpreted as their pathophysiologic function.

A decreased peritumoral CD1a+ cell number predicts a worse prognosis in oral squamous cell carcinoma

“…A relationship between DCs and prognosis in patients affected by different cancers has been previously reported . However, for oral cancer, the present data are still unclear .…”

“…A relationship between DCs and prognosis in patients affected by different cancers has been previously reported . However, for oral cancer, the present data are still unclear . Thus, the purpose of this study was to evaluate the prognostic impact of intratumoral and peritumoral DCs in OSCC affecting the tongue and floor of the mouth.…”

Melanomas and Dysplastic Nevi Differ in Epidermal CD1c+ Dendritic Cell Count

“…Recently, presence of CD1a-positive DCs around the tumor cell nests was also observed to correlate with the absence of hematogenous spread in malignant melanoma of the skin [36]. In other human malignancies the decreased number of CD1a-positive DCs in tumor area is often associated with the progression of the disease and unfavourable prognosis [11, 14]. …”

“…The role of DCs in development and propagation of various human cancers including breast, colon, esophageal, lung, and oral carcinoma [9–14] has been previously described. However, the role of dendritic cells and their cutaneous subtypes in the evolution of primary malignant melanoma remains to be confirmed as there are very few publications addressing this issue.…”

CD207+/langerin positive dendritic cells in invasive and in situ cutaneous malignant melanoma

“…The DCs constitute a complex system of cells found in peripheral tissues as well as immunological organs, and their presence was also documented in a vast range of human malignant tumours [20–25]. Response to cancer cells involves the capture of foreign antigens by immature DC subsets, their entailing maturation, migration to the lymph nodes and presentation of antigen peptides to T cells via major histocompatibility complex (MHC) molecules.…”