A decreased peritumoral <scp>CD</scp>1a+ cell number predicts a worse prognosis in oral squamous cell carcinoma

Jardim, Juscelino Freitas; Gondak, Rogério; Galvis, Marisol Miranda; Pinto, Clóvis Antônio Lopes; Kowalski, Luiz Paulo

doi:10.1111/his.13415

Cited by 40 publications

(37 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Seven different articles assessed the prognostic value of DC, using seven different markers 28,45,[53][54][55][56][57] (Table 2). High numbers of both immature CD209+ DC and plasmacytoid CD123+ DC were associated with decreased survival in one study, whereas high numbers of the other subsets of DC were mostly associated with improved survival.…”

Section: T Cells B Cells DC and Mast Cells Lack Evidence Of Prognosmentioning

confidence: 99%

Tissue-infiltrating immune cells as prognostic markers in oral squamous cell carcinoma: a systematic review and meta-analysis

Hadler‐Olsen

Wirsing

2019

Br J Cancer

View full text Add to dashboard Cite

BACKGROUND: Various immune cells have been suggested as prognostic markers for cancer patients. In this article, we present a systematic review and meta-analysis of studies assessing the prognostic value of tissue-infiltrating immune cells in oral cancer and discuss the reporting quality of these studies. METHODS: We performed a systematic literature search and included studies using immunohistochemistry and survival analysis to assess the prognostic value of tumour-infiltrating T cells, B cells, macrophages, dendritic cells, mast cells and natural killer cells in oral cancer. We performed meta-analysis of studies providing necessary statistical data and investigated the studies' adherence to the REporting recommendations for tumour MARKer prognostic studies (REMARK) guidelines. RESULTS: Of the 1960 articles identified, 33 were eligible for this systematic review and 8 were included in the meta-analysis. CD163+ M2 macrophages and CD57+ natural killer cells were the most promising predictors of survival in oral cancer patients. Many studies lacked important information on their design and conduct. CONCLUSION: Deficiencies in the reporting of study design and conduct make it difficult to draw reliable conclusions about the suggested markers. The prognostic value of CD163+ M2 macrophages and CD57+ natural killer cells should be validated in large, standardised studies.

show abstract

Section: T Cells B Cells DC and Mast Cells Lack Evidence Of Prognosmentioning

confidence: 99%

Tissue-infiltrating immune cells as prognostic markers in oral squamous cell carcinoma: a systematic review and meta-analysis

Hadler‐Olsen

Wirsing

2019

Br J Cancer

View full text Add to dashboard Cite

show abstract

“…There is a growing number of evidences supporting the hypothesis that different subtypes of DC play important roles in the immunosurveillance against neoplastic cells and that the distribution and/or the regular function of these cellular populations are altered in many human tumors including oral cancer, lip cancer, mycosis fungoids, cutaneous squamous cell carcinomas, and others (8)(9)(10)(11). Moreover, different authors have attributed a significant prognostic importance for DC in several of these malignant neoplasms (12,13), speculating that changes in these cells would not only predispose to neoplastic development, but it would also represent potential therapeutic targets for future chemotherapy schemes.…”

Section: Discussionmentioning

confidence: 99%

Distribution of Dendritic Cells in AIDS-Associated Oral Kaposi’s Sarcoma

et al. 2019

View full text Add to dashboard Cite

The aim of this study was to determine if the distribution of Langerhans cells (LC) and interstitial dendritic cells (IDC) is altered in AIDS-associated oral Kaposi’s sarcoma when compared to HIV-negative highly vascular oral lesions. Fifty-one cases of AIDS-associated oral Kaposi’s sarcoma and 20 of highly vascular oral lesions were retrospectively retrieved. All cases of Kaposi’s sarcoma were confirmed with immunoreactions against CD34 and HHV-8. Clinical data regarding sex, age and lesions location were obtained from pathology reports. Immunohistochemistry against CD207 (immature dendritic cells) and CD83 (mature dendritic cells) were done. LC were in the epithelium and IDC in the stroma. CD207+ cells predominated in the epithelium of the lesions, whereas CD83+ cells predominated in their stromal compartment. Kaposi’s sarcoma had a lower CD207+ immature LC count (p=0.02) and an increased CD207+ IDC than highly vascular oral lesions (p<0.001). Moreover, Kaposi’s sarcoma also showed an increased number of mature CD83+ IDC than highly vascular oral lesions (p<0.001). There were significant alterations in the distribution of LC and IDC in AIDS-associated Kaposi’s sarcoma when compared to HIV-negative vascular oral lesions, suggesting that changes in their concentrations may play a role in the pathogenesis of Kaposi’s sarcoma.

show abstract

“…Positive controls were included in all reactions in accordance with the manufacturer's protocols. The selection of the antibodies was based on their well-established biological properties and previous investigations in different neoplasms The immunohistochemical stains were evaluated by automated examination based on a previous methodology (25). All slides were scanned with the Scan Scope Aperio System (Aperio, Vista, CA, USA) obtaining a high-quality resolution digital image.…”

Section: Methodsmentioning

confidence: 99%

“…Once there are no studies that investigate DCs in HNC in HIV-positive patients, the quantification of these cells is prime for a better understanding of this subject and may reveal important data for future steps. However, a great variability of values has been noticed in studies investigating the density of DCs (19,(22)(23)(24)(25), which complicate the use of published data as reference for new studies.…”

Section: Introductionmentioning

confidence: 99%

Different methods of cell quantification can lead to different results: a comparison of digital methods using a pilot study of dendritic cells in HIV-positive patients

Fernandes

Heerden²,

Ribeiro³

et al. 2020

Med Oral

View full text Add to dashboard Cite

Background: Although new digital pathology tools have improved the positive cell quantification, there is a heterogeneity of the quantification methods in the literature. The aim of this study was to evaluate and propose a novel dendritic cells quantification method in squamous cell carcinoma comparing it with a conventional quantification method. Material and Methods: Twenty-six squamous cell carcinomas HIV-positive cases affecting the oropharynx, lips and oral cavity were selected. Immunohistochemistry for CD1a, CD83, and CD207 was performed. The immunohistochemical stains were evaluated by automated examination using a positive pixel count algorithm. A conventional quantification method (unspecific area method; UA) and a novel method (specific area method; SA) were performed obtaining the corresponding density of positive dendritic cells for the intratumoral and peritumoral regions. The Mann-Whitney U test was used to verify the influence of the quantification methods on the

show abstract

A decreased peritumoral CD1a+ cell number predicts a worse prognosis in oral squamous cell carcinoma

Abstract: Our results suggest that depletion of peritumoral CD1a+ cells is a strong independent prognostic factor, predicting a higher recurrence rates and worse survival outcomes.

Cited by 40 publications

References 29 publications

Tissue-infiltrating immune cells as prognostic markers in oral squamous cell carcinoma: a systematic review and meta-analysis

Tissue-infiltrating immune cells as prognostic markers in oral squamous cell carcinoma: a systematic review and meta-analysis

Distribution of Dendritic Cells in AIDS-Associated Oral Kaposi’s Sarcoma

Different methods of cell quantification can lead to different results: a comparison of digital methods using a pilot study of dendritic cells in HIV-positive patients

Contact Info

Product

Resources

About