CD207+/langerin positive dendritic cells in invasive and  in situ  cutaneous malignant melanoma

Dyduch, Grzegorz; Tyrak, Katarzyna Ewa; Glajcar, Anna; Szpor, Joanna; Okoń, Krzysztof

doi:10.5114/ada.2017.67845

Cited by 5 publications

(7 citation statements)

References 56 publications

(53 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Immature LCs are potent inducers of immune tolerance; however, upon maturation these cells are capable of activating effective antigen-specific immune responses ( 132 ). Infiltration of immature CD207 + /Langerin + DCs in the peritumoral area of invasive cutaneous malignant melanoma (CMM) is correlated with increased tumor growth, a high mitotic rate, and CMM ulcer development, all leading to disease exacerbation and a worse prognosis ( 133 ). Also, the infiltration of Langerin + cells in Hodgkin lymphomas and in nasopharyngeal carcinomas has been associated with the already well-characterized, strong immunosuppressive tumor microenvironment in these two types of cancers ( 134 ).…”

Section: Interaction With the Immune Systemmentioning

confidence: 99%

Fucosylated Antigens in Cancer: An Alliance toward Tumor Progression, Metastasis, and Resistance to Chemotherapy

et al. 2018

View full text Add to dashboard Cite

Aberrant glycosylation of tumor cells is recognized as a universal hallmark of cancer pathogenesis. Overexpression of fucosylated epitopes, such as type I (H1, Lewisa, Lewisb, and sialyl Lewisa) and type II (H2, Lewisx, Lewisy, and sialyl Lewisx) Lewis antigens, frequently occurs on the cancer cell surface and is mainly attributed to upregulated expression of pertinent fucosyltransferases (FUTs). Nevertheless, the impact of fucose-containing moieties on tumor cell biology is not fully elucidated yet. Here, we review the relevance of tumor-overexpressed FUTs and their respective synthesized Lewis determinants in critical aspects associated with cancer progression, such as increased cell survival and proliferation, tissue invasion and metastasis, epithelial to mesenchymal transition, epithelial and immune cell interaction, angiogenesis, multidrug resistance, and cancer stemness. Furthermore, we discuss the potential use of enhanced levels of fucosylation as glycan biomarkers for early prognosis, diagnosis, and disease monitoring in cancer patients.

show abstract

Section: Interaction With the Immune Systemmentioning

confidence: 99%

Fucosylated Antigens in Cancer: An Alliance toward Tumor Progression, Metastasis, and Resistance to Chemotherapy

et al. 2018

View full text Add to dashboard Cite

show abstract

“…These mechanisms are probably responsible for the association of worse prognosis in different neoplasms with high degree infiltration with DCs, and especially CD123-and CD207-positive cells. These correlations are observed in melanoma, when the infiltration is higher in different parts of the tumour [28,29]. The infiltration with CD123-positive cells as bad predictor is also described in breast cancer, where the high degree of infiltration is an in dependent prognostic factor for determining survival and prognosis [30,31].…”

Section: Discussionmentioning

confidence: 83%

CD11c- and CD123-positive dendritic cells in development of antitumour immunity in non-small cell lung cancer patients

Minkov¹,

Gulubova²,

Ivanova³

et al. 2019

pjp

View full text Add to dashboard Cite

Our aim was to analyzed the significance of CD11c and CD123 positive DCs and their relations with some clinical and pathologic parameters of patients with nonsmall cell lung cancer (NSCLC). The immunohistochemical expression of CD11c and CD123, was evaluated in 40 patients with NSCLC. After analysis we found that 35.3% of the patients in the T3-4 tumour stage had a high CD11c infiltration in the tumour stroma, while 100% of the patients in the T1-2 tumour stage had low infiltration (p = 0.03). We also found that 71.4% of patients in the M1 stage had a high infiltration with CD123 in the tumour stroma, whereas only 15.6% of patients without metastases had high infiltration, analogous data are also found in comparing the distribution of CD123 in the tumour border (p = 0.002 or p = 0.002). Comparing the density of CD123 in the border of lymph node involvement, we found that only 7.14% of patients without metastases had low infiltration with dendritic cells, whereas in patients with metastatic lymph nodes that percentage was 41.7% (p = 0.008). In conclusion results suggest that CD11c-and CD123-positive DCs play an important role in antitumour immunity and can be predictive factor for tumour development in patients with NSCLC.

show abstract

“…83 Post-hoc analysis of the Sunbelt trial results regarding the impact of ulceration of the primary tumor on adjuvant IFNtreatment efficacy in sentinel node positive patients demonstrated that a significant improvement of disease-free survival was observed only in IFN-treated patients with an ulcerated primary. 78,84 While IFN therapy use in melanoma has declined since the completion of these trials, the results indicate a clear difference in the tumor immune response when ulceration is present in the primary tumor. The impact of ulceration should therefore be considered in the evaluation of any melanoma immune-based treatment.…”

Section: Interferonsmentioning

confidence: 99%

“…More immunosuppressed dendritic cells [77] ↑ peritumoral CD207/langerin+ dendritic cells [78] ↓ LAMP+ dendritic cells [77] Cytokine profile ↑ IL6 gene expression [12] Response to therapy ↑ response to adjuvant IFN [11,[80][81][82][83][84] Clinical, Cosmetic and Investigational Dermatology 2022:15 https://doi.org/10.2147/CCID.S372287…”

Section: Dendritic Cellsmentioning

confidence: 99%

See 1 more Smart Citation

Ulcerated Cutaneous Melanoma: A Review of the Clinical, Histologic, and Molecular Features Associated with a Clinically Aggressive Histologic Phenotype

Barricklow¹,

DiVincenzo²,

Carson³

et al. 2022

CCID

View full text Add to dashboard Cite

The presence of ulceration in melanoma is associated with poor clinical outcomes and is the third most powerful predictor of survival in the AJCC Melanoma Staging System after tumor thickness and mitotic activity. The aggressive biological behavior associated with ulceration has been hypothesized to be the result of an intrinsic biological attribute that favors dissemination and presents locally with the loss of epidermal integrity. Among the features of ulcerated melanoma, many show promise as potential prognostic tools, markers of differential immunogenicity and indicators of oncogenic drivers of invasion and metastasis. The incidence of ulcerated melanoma is greater in males, increases with age and with systemic inflammatory risk factors (diabetes, smoking, low vitamin D, elevated body mass index). Patients with ulcerated primary tumors seem to exclusively benefit from adjuvant interferon (IFN) therapy, which is likely the consequence of an altered tumor microenvironment. When ulceration is present, there is a higher density of macrophages and dendritic cells and enhanced expression of pro-inflammatory cytokines, such as IL-6. There is also an increased expression of proteins involved in tumor antigen presentation in ulcerated melanomas. Histologically, vascular density, vasculogenic mimicry and angiotropism are all significantly correlated with ulceration in melanoma. The presence of ulceration is associated with reduced protein expression of E-cadherin and PTEN and elevated levels of N-cadherin and the matrix metalloproteinases. Differential microRNA expression also holds promise as a potential prognostic biomarker of malignancy and disease spread within the setting of ulceration. However, the molecular and cellular differences associated with the ulcerated state are complex and further study will aid in determining how these differences can be harnessed to improve care for patients with melanoma.

show abstract

CD207+/langerin positive dendritic cells in invasive and in situ cutaneous malignant melanoma

Cited by 5 publications

References 56 publications

Fucosylated Antigens in Cancer: An Alliance toward Tumor Progression, Metastasis, and Resistance to Chemotherapy

Fucosylated Antigens in Cancer: An Alliance toward Tumor Progression, Metastasis, and Resistance to Chemotherapy

CD11c- and CD123-positive dendritic cells in development of antitumour immunity in non-small cell lung cancer patients

Ulcerated Cutaneous Melanoma: A Review of the Clinical, Histologic, and Molecular Features Associated with a Clinically Aggressive Histologic Phenotype

Contact Info

Product

Resources

About