A Comparative Analysis of Fluoride-Contaminated Groundwater and Sodium Fluoride-Induced Reproductive Toxicity and Its Reversibility in Male Rats

Chaithra, B; Sarjan, Halugudde Nagaraja; Shivabasavaiah,

doi:10.1007/s12011-019-01994-y

Cited by 20 publications

(5 citation statements)

References 42 publications

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“…Similarly, previous studies have also documented reduced sperm count and increased sperm abnormalities in mice exposed to F-contaminated drinking water (Wei et al, 2016;Sun et al, 2017). Toxic effects of NaF and F on male reproduction have been reported, taking the form of reduced sperm motility, testicular steroidogenesis, increased sperm abnormalities, histological alterations in the testis, and the loss of different stages of spermatozoa and spermatogenesis in the lumen of the Frontiers in Environmental Science frontiersin.org seminiferous tubules of the testis (Chaithra et al, 2020). Furthermore, recent studies have documented the finding that F exposure can lead to mitochondrial damage and ROS accumulation, leading to mitochondrial fission/fusion imbalances (Zhou et al, 2020).…”

Section: Discussionmentioning

confidence: 54%

Cytotoxic effects of heavy metals on functional attributes of boar sperm: an in vitro study

Kadirvel,

Diengdoh,

Deori

et al. 2023

Front. Environ. Sci.

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Objective: Reproductive toxicology is a field that deals with the effects of heavy metals on various aspects of reproduction, including sperm count, motility, viability, spermatogenesis, follicular atresia, hormonal imbalance, and oocyte maturation, among others. The present study was carried out to examine the effects of heavy metals, viz., arsenic (As), lead (Pb), and fluoride (F), on boar sperm quality parameters in vitro.Materials and Methods: Forty (40) ejaculates from six (6) boars, averaging eight ejaculates per boar, were collected with the gloved hand technique using a dummy sow. Six (6) different concentrations were selected for the in vitro study: 5, 10, 25, 50, 100, and 200 µM for As and Pb, and 5, 10, 25, 50, 100, and 200 mM for F. The ejaculates were co-incubated with heavy metals at these different concentrations and assessed after different incubation periods (0, 0.5, and 1 h) for sperm functional attributes, viz., sperm progressive motility, viability and membrane integrity, and sperm mitochondrial membrane potential (MMP). The combined effects of heavy metals on sperm functional attributes were also evaluated at different doses (5, 10, 25, 50, 100, and 200 μM/μM for As–Pb; 5, 10, 25, 50, 100, and 200 μM/mM for As–F; and 5, 10, 25, 50, 100, and 200 μM/mM for Pb–F).Results: The present study revealed a highly significant (p <0.001) decrease in sperm progressive motility, viable sperm, membrane integrity, and sperm MMP in samples treated with heavy metals under different incubation periods; furthermore, the longer the incubation time, the greater the toxicity. There was also a significant (p <0.05) decrease in sperm motility, membrane integrity, and MMP in the samples treated with combined heavy metals (As–Pb, As–F, and Pb–F), as compared to the control, after different incubation periods. A significant (p <0.05) reduction in sperm quality attributes was recorded even at the lowest concentrations in the case of heavy metal combinations.Conclusion: It can be concluded that As, Pb, and F are toxic to boar spermatozoa in vitro, causing reductions in sperm functional attributes in a dose- and time-dependent manner.

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Section: Discussionmentioning

confidence: 54%

Cytotoxic effects of heavy metals on functional attributes of boar sperm: an in vitro study

Kadirvel,

Diengdoh,

Deori

et al. 2023

Front. Environ. Sci.

View full text Add to dashboard Cite

show abstract

“…Similarly, previous studies have also documented reduced sperm count and increased sperm abnormalities in mice exposed to F-contaminated drinking water (Wei et al, 2016;Sun et al, 2017). Toxic effects of NaF and F on male reproduction have been reported, taking the form of reduced sperm motility, testicular steroidogenesis, increased sperm abnormalities, histological alterations in the testis, and the loss of different stages of spermatozoa and spermatogenesis in the lumen of the Frontiers in Environmental Science frontiersin.org 08 Kadirvel et al 10.3389/fenvs.2023.1296606 seminiferous tubules of the testis (Chaithra et al, 2020). Furthermore, recent studies have documented the finding that F exposure can lead to mitochondrial damage and ROS accumulation, leading to mitochondrial fission/fusion imbalances (Zhou et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Recent Research Advances on Heavy Metals, Microplastics, Persistent Organic Pollutants, and Solid Waste in Aquatic and Terrestrial Ecosystems

Zhang,

Xu,

Guo

et al. 2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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“…An animal study has documented that fluoride impairs male rabbits' reproductive functions, with such effect related to fluoride exposure time [80]. In that study, exposure to NaF-and F-contaminated groundwater resulted in a significant reduction in total sperm count, sperm motility, concentration of serum testosterone compared to control in a dose dependent manner and reversible on short-term exposure [84]. Negative effects were also reported in female mice, confirming the negative effects of excess fluoride on fertility.…”

Section: Fertility and Perinatal Periodmentioning

confidence: 99%

Dietary Micronutrients from Zygote to Senility: Updated Review of Minerals’ Role and Orchestration in Human Nutrition throughout Life Cycle with Sex Differences

et al. 2021

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Micronutrients such as selenium, fluoride, zinc, iron, and manganese are minerals that are crucial for many body homeostatic processes supplied at low levels. The importance of these micronutrients starts early in the human life cycle and continues across its different stages. Several studies have emphasized the critical role of a well-balanced micronutrient intake. However, the majority of studies looked into or examined such issues in relation to a specific element or life stage, with the majority merely reporting the effect of either excess or deficiency. Herein, in this review, we will look in depth at the orchestration of the main element requirements across the human life cycle beginning from fertility and pregnancy, passing through infancy, childhood, adolescence, and reaching adulthood and senility, with insight on the interactions among them and underlying action mechanisms. Emphasis is given towards approaches to the role of the different minerals in the life cycle, associated symptoms for under- or overdoses, and typical management for each element, with future perspectives. The effect of sex is also discussed for each micronutrient for each life stage as literature suffice to highlight the different daily requirements and or effects.

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A Comparative Analysis of Fluoride-Contaminated Groundwater and Sodium Fluoride-Induced Reproductive Toxicity and Its Reversibility in Male Rats

Cited by 20 publications

References 42 publications

Cytotoxic effects of heavy metals on functional attributes of boar sperm: an in vitro study

Cytotoxic effects of heavy metals on functional attributes of boar sperm: an in vitro study

Recent Research Advances on Heavy Metals, Microplastics, Persistent Organic Pollutants, and Solid Waste in Aquatic and Terrestrial Ecosystems

Dietary Micronutrients from Zygote to Senility: Updated Review of Minerals’ Role and Orchestration in Human Nutrition throughout Life Cycle with Sex Differences

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