A compact and highly sensitive light-emitting diode-induced fluorescence detector for capillary flow systems

Geng, Xuhui; Wu, Dapeng; Guan, Yafeng

doi:10.1016/j.talanta.2011.11.015

Cited by 22 publications

(13 citation statements)

References 16 publications

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“…Capacitively coupled contactless conductivity (C 4 D) [4][5][6][7], LED induced fluorescence (LEDIF) [8,9] and electrochemical detectors [10,11] are quite promising tools for the minia-turization of analytical devices due to small-scale integrated circuits (IC) available on the market, which are suitable for detector fabrication. However, the design of such detectors is still a challenge and only a few state-of-the-art devices could be found in the literature [7,8].…”

Section: Introductionmentioning

confidence: 99%

“…Particular attention should be paid to lab-on-a-robot [12] or planetary rover [13,14] detection systems due to their special requirements for power consumption and size. LEDIF detectors are common alternatives to stand-alone systems; however, a single LED can consume 20 to 50 mW of power [8,9]. LEDIF detectors are common alternatives to stand-alone systems; however, a single LED can consume 20 to 50 mW of power [8,9].…”

Section: Introductionmentioning

confidence: 99%

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Capacitance‐to‐digital: A single chip detector for capillary electrophoresis

2014

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A capacitance-to-digital converter integrated circuit was implemented in an automated CE device as a single chip detector. In this paper, design and hardware issues related to the fabrication and application of a miniature detector for contactless measurement of complex impedance are discussed. The capacitance-to-digital converter integrated circuit was used as the whole detector. The advantage of this setup is that the single integrated circuit provides digital data and neither additional signal conditioning nor analog-to-digital converter is required. Different separation conditions were used to evaluate the detection characteristics of the constructed detection unit. A 1 μM LOD for sodium and a 1.6 μM LOD for potassium ions were revealed for the detector. The detection system designed is competitive with miniaturized contactless conductivity detectors or UV absorbance detectors with respect to overall parameters (sensitivity, resolution, power consumption properties, and size). The obtained separation and detection results show that such detection technique can be used as an extremely low power consuming and space saving solution for CE detection with potential applications in environmental monitoring, process control, and various analytical measurements.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Capacitance‐to‐digital: A single chip detector for capillary electrophoresis

2014

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“…An LOD of 0.15 nM (SNR¼3) was achieved finally. Compared with our previous LED-FD [14], a five-fold enhancement on the SNR was obtained. The new detector was combined with an Agilent 1200 Series HPLC system to separate and detect four kinds of amino acids to demonstrate its applicability.…”

Section: Introductionmentioning

confidence: 59%

“…From Fig. 3d, the LOD (SNR ¼3) of our improved detector was estimated to be 0.15 nM, which was only 1/5 of our latest report [14]. The size of the whole detector was only 9 cm Â 9 cm Â 4 cm (W Â L Â H).…”

Section: System Characteristicsmentioning

confidence: 68%

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Signal-to-noise ratio enhancement of the compact light-emitting diode-induced fluorescence detector

Geng

et al. 2012

Talanta

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Recent developments in capillary and microchip electroseparations of peptides (2011–2013)

Kašička

2013

Electrophoresis

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The review presents a comprehensive survey of recent developments and applications of capillary and microchip electroseparation methods (zone electrophoresis, ITP, IEF, affinity electrophoresis, EKC, and electrochromatography) for analysis, isolation, purification, and physicochemical and biochemical characterization of peptides. Advances in the investigation of electromigration properties of peptides, in the methodology of their analysis, including sample preseparation, preconcentration and derivatization, adsorption suppression and EOF control, as well as in detection of peptides, are presented. New developments in particular CE and CEC modes are reported and several types of their applications to peptide analysis are described: conventional qualitative and quantitative analysis, determination in complex (bio)matrices, monitoring of chemical and enzymatical reactions and physical changes, amino acid, sequence and chiral analysis, and peptide mapping of proteins. Some micropreparative peptide separations are shown and capabilities of CE and CEC techniques to provide relevant physicochemical characteristics of peptides are demonstrated.

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A compact and highly sensitive light-emitting diode-induced fluorescence detector for capillary flow systems

Cited by 22 publications

References 16 publications

Capacitance‐to‐digital: A single chip detector for capillary electrophoresis

Capacitance‐to‐digital: A single chip detector for capillary electrophoresis

Signal-to-noise ratio enhancement of the compact light-emitting diode-induced fluorescence detector

Recent developments in capillary and microchip electroseparations of peptides (2011–2013)

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