A Common Feature of Pesticides: Oxidative Stress—The Role of Oxidative Stress in Pesticide-Induced Toxicity

Sule, Rasheed; Condon, Liam; Gomes, Aldrin V.

doi:10.1155/2022/5563759

Cited by 183 publications

(132 citation statements)

References 288 publications

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“…ROS can cause damage to biomolecules leading to cell and tissue injury [ 76 ]. Moreover, it is recorded that acetochlor/herbicides mainly induce an increased lipid peroxidation and ROS production process, leading to damage to DNA, proteins, lipids, and carbohydrates that consequently affect the immune functions [ 77 – 82 ].…”

Section: Discussionmentioning

confidence: 99%

[Retracted] Acetochlor Affects Bighead Carp (Aristichthys Nobilis) by Producing Oxidative Stress, Lowering Tissue Proteins, and Inducing Genotoxicity

Mahmood

Hussain

Ghaffar

et al. 2022

BioMed Research International

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Acetochlor is persistently used in the agroproduction sector to control broadleaf weeds. Due to frequent and continuous applications, this herbicide can reach nearby water bodies and may induce deleterious changes in aquatic life. Therefore, investigation of harmful impacts of different environmental pollutants, including herbicides, is vital to knowing the mechanisms of toxicity and devising control strategies. The current experiment included bighead carp ( n = 80 ) to estimate adverse impacts. Fish were randomly placed in 4 different experimental groups (T0-T3) and were treated for 36 days with acetochlor at 0, 300, 400, and 500 μg/L. Fresh blood without any anticoagulant was obtained and processed for nuclear and morphological changes in erythrocytes. At the same time, various visceral organs, including the gills, liver, brain, and kidneys, were removed and processed on days 12, 24, and 36 to determine oxidative stress and various antioxidant biomarkers. Comet assays revealed significantly increased DNA damage in isolated cells of the liver, kidneys, brain, and gills of treated fish. We recorded increased morphological and nuclear changes ( P ≤ 0.05 ) in the erythrocyte of treated fish. The results on oxidative stress showed a higher quantity of oxidative biomarkers and a significantly ( P ≤ 0.05 ) low concentration of cellular proteins in the gills, liver, brain, and kidneys of treated fish compared to unexposed fish. Our research findings concluded that acetochlor renders oxidative stress in bighead carp.

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Section: Discussionmentioning

confidence: 99%

[Retracted] Acetochlor Affects Bighead Carp (Aristichthys Nobilis) by Producing Oxidative Stress, Lowering Tissue Proteins, and Inducing Genotoxicity

Mahmood

Hussain

Ghaffar

et al. 2022

BioMed Research International

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“…In addition, inhibition of the transcription levels of pro-inflammatory cytokines, which are related to oxidative stress, might be caused by insecticides. This results in increasing ROS and DNA damage, as well as the induction of apoptosis [ 36 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

Pesticide Exposure and Risk of Rheumatoid Arthritis: A Systematic Review and Meta-Analysis

Chittrakul

Sapbamrer

Sirikul

2022

Toxics

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Rheumatoid arthritis (RA) is a disease that affects people all over the world and can be caused by a variety of factors. Exposure to pesticides is one of the risk factors for the development of RA. However, the evidence of exposure to pesticides linked with the development of RA is still controversial. This study aimed to investigate the association between exposure to pesticides and RA by a systematic review of relevant literature and a meta-analysis. Full-text articles published in PubMed, Web of Science, Scopus, and Google Scholar between 1956 and 2021 were reviewed and evaluated. A total of eight studies were eligible for inclusion (two cohort studies, four case-control studies, and two cross-sectional studies). The adjusted odds ratio for pesticide exposure on RA was 1.20 for insecticides (95% CI = 1.12–1.28), 0.98 for herbicides (95% CI = 0.89–1.08), 1.04 for fungicides (95% CI = 0.86–1.27), and 1.15 in for non-specific pesticides (95% CI = 1.09–1.21). There is some evidence to suggest that exposure to insecticides (especially fonofos, carbaryl, and guanidines) contributes to an increased risk of RA. However, the evidence is limited because of a small number of studies. Therefore, further epidemiological studies are needed to substantiate this conclusion.

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“…This might be due to a high resistance of CG components in porcine oocytes to DT exposure. A number of studies have shown that environmental pollutant exposure generally activates the process of oxidative stress in cells [ 51 ]. Concomitantly, the increased oxidative stress induces DNA damage and excessive autophagy, thereby impairing cellular functions [ 40 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

Melatonin Rescues Dimethoate Exposure-Induced Meiotic and Developmental Defects of Porcine Oocytes

Jiang

Ding

et al. 2022

Animals

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Dimethoate (DT) is an environmental pollutant widely used in agricultural fields and home gardens. Studies have shown that exposure to DT causes reproductive defects in both male and female animals. However, the effects of DT exposure on oocyte maturation and the approach to counteract it are not yet known. Here, we investigated the toxicity of DT on porcine oocyte maturation and the protective effects of melatonin (MT) on DT-exposed oocytes. DT exposure with 1.5 mM partially inhibited cumulus cell expansion and significantly reduced the rate of first polar body extrusion (pb1) during oocyte maturation. Parthenogenetically activated embryos derived from DT-exposed oocytes could not develop to the 2-cell and blastocyst stage. Furthermore, DT exposure led to a significant increase in the rates of misaligned chromosomes, disorganized spindles, and abnormal actin assembly. DT exposure severely disrupted the distribution patterns of mitochondria in oocytes but did not change the subcellular localizations of cortical granules. Importantly, MT supplementation rescued the meiotic and developmental defects of DT-exposed oocytes through repressing the generation of excessive reactive oxygen species (ROS) and autophagy, and DNA damage accumulation. These results demonstrate that melatonin protects against meiotic defects induced by DT during porcine oocyte maturation.

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A Common Feature of Pesticides: Oxidative Stress—The Role of Oxidative Stress in Pesticide-Induced Toxicity

Cited by 183 publications

References 288 publications

[Retracted] Acetochlor Affects Bighead Carp (Aristichthys Nobilis) by Producing Oxidative Stress, Lowering Tissue Proteins, and Inducing Genotoxicity

[Retracted] Acetochlor Affects Bighead Carp (Aristichthys Nobilis) by Producing Oxidative Stress, Lowering Tissue Proteins, and Inducing Genotoxicity

Pesticide Exposure and Risk of Rheumatoid Arthritis: A Systematic Review and Meta-Analysis

Melatonin Rescues Dimethoate Exposure-Induced Meiotic and Developmental Defects of Porcine Oocytes

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