Pesticide Exposure and Risk of Rheumatoid Arthritis: A Systematic Review and Meta-Analysis

Chittrakul, Jiraporn; Sapbamrer, Ratana; Sirikul, Wachiranun

doi:10.3390/toxics10050207

Cited by 6 publications

(4 citation statements)

References 38 publications

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“…Exposure to these chemicals can cause both acute and chronic health consequences (4). Several studies have shown that exposure to OP was associated with chronic diseases such as asthma, rheumatoid arthritis, cancers, Alzheimer's disease, Parkinson's disease, and cognitive impairment (6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Exposure to organophosphate insecticides, inappropriate personal protective equipment use, and cognitive performance among pesticide applicators

Chittrakul

Sapbamrer

Hongsibsong

2022

Front. Public Health

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Inappropriate use of personal protective equipment (PPE) among pesticide applicators may increase urinary organophosphate (OP) metabolite levels and subsequently increase risks of cognitive performance. Therefore, this study aims to (1) compare urinary OP metabolite levels and cognitive performance between pre-and post-pesticide application seasons; (2) PPE use and factors associated with PPE use linked to increased urinary OP metabolite levels during pesticide application; and (3) the association between urinary OP metabolite levels and cognitive performance. This longitudinal follow-up study on 79 pesticide applicators was carried out between October 2021 and January 2022. The applicators were interviewed, collected urine samples, and tested for cognitive performance in pre-and post-pesticide application seasons. The results found that the levels of urinary OP metabolites in post-application season were significantly higher than those in pre-application season (p < 0.001). Multiple linear regression analysis found that increased total diethylphosphate (DEP) and total dialkylphosphate (DAP) levels were associated with not wearing gloves while mixing pesticides [beta (β) ± standard error (SE) = −43.74 ± 18.52, 95% confidence interval (95% CI) = −80.84, −6.64 for total DEP and −50.84 ± 19.26, 95% CI = −89.41, −12.26 for total DAP] and also with not wearing a mask while spraying pesticides (β ± SE = −31.76 ± 12.24, 95% CI = −56.28, −7.24 for total DEP and −33.20 ± 12.63, 95% CI = −58.49, −7.92 for total DAP) after adjusting for covariates. The scores of Montreal Cognitive Assessment-Thai, Thai Mental State Examination, and Mini-Cognitive test in post-pesticide application were significantly lower than those in pre-pesticide application (p < 0.001). However, no association was found between urinary OP metabolite levels and cognitive decline. Our findings indicate that inappropriate PPE use during pesticide application was the major factor affecting urinary OP metabolite levels among pesticide applicators. Wearing gloves when mixing pesticides and a mask when spraying pesticides were key factors in reducing occupational exposure to OP. Exposure to OP at low levels and for short periods of exposure may not affect cognitive performance significantly. Therefore, long-term exposure and exposure to high levels of OP should be investigated further.

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Section: Introductionmentioning

confidence: 99%

Exposure to organophosphate insecticides, inappropriate personal protective equipment use, and cognitive performance among pesticide applicators

Chittrakul

Sapbamrer

Hongsibsong

2022

Front. Public Health

Self Cite

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“…The mechanisms through which toxic chemical exposure may contribute to MS onset remains are not completely understood. Exposure to weed control agents can alter immune response, potentially resulting in inflammatory diseases, including rheumatoid arthritis and systematic lupus erythematosus 23 24. Glyphosate (RoundUp) can induce the nuclear factor-kappa B ( NF-κB ) signalling pathway in several human cell types14 15 25 inducing gene expression of proinflammatory cytokines like TNF- α, IL-1 and IL-6.…”

Section: Discussionmentioning

confidence: 99%

Gene–environment interactions increase the risk of paediatric-onset multiple sclerosis associated with household chemical exposures

Nasr

Schoeps

Ziaei

et al. 2023

J Neurol Neurosurg Psychiatry

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BackgroundWe previously reported an association between household chemical exposures and an increased risk of paediatric-onset multiple sclerosis.MethodsUsing a case–control paediatric multiple sclerosis study, gene–environment interaction between exposure to household chemicals and genotypes for risk of paediatric-onset multiple sclerosis was estimated.Genetic risk factors of interest included the two major HLA multiple sclerosis risk factors, the presence ofDRB1*15and the absence ofA*02,and multiple sclerosis risk variants within the metabolic pathways of common household toxic chemicals, includingIL-6(rs2069852),BCL-2(rs2187163) andNFKB1(rs7665090).Results490 paediatric-onset multiple sclerosis cases and 716 controls were included in the analyses. Exposures to insect repellent for ticks or mosquitos (OR 1.47, 95% CI 1.06 to 2.04, p=0.019), weed control products (OR 2.15, 95% CI 1.51 to 3.07, p<0.001) and plant/tree insect or disease control products (OR 3.25, 95% CI 1.92 to 5.49, p<0.001) were associated with increased odds of paediatric-onset multiple sclerosis. There was significant additive interaction between exposure to weed control products andNFKB1SNP GG (attributable proportions (AP) 0.48, 95% CI 0.10 to 0.87), and exposure to plant or disease control products and absence ofHLA-A*02(AP 0.56; 95% CI 0.03 to 1.08). There was a multiplicative interaction between exposure to weed control products andNFKB1SNP GG genotype (OR 2.30, 95% CI 1.00 to 5.30) but not for other exposures and risk variants. No interactions were found withIL-6andBCL-2SNP GG genotypes.ConclusionsThe presence of gene–environment interactions with household toxins supports their possible causal role in paediatric-onset multiple sclerosis.

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“…Among the various risk factors for the development of RA, a systematic review of relevant literature between 1956 and 2021 and a meta-analysis were conducted to investigate the association between pesticide exposure and RA [ 116 ]. A total of eight studies were eligible for inclusion (two cohort studies, four case–control studies, and two cross-sectional studies) and showed that exposure to insecticides (especially fonofos, carbaryl, and guanidines) contributes to an increased risk of RA.…”

Section: Immune-mediated Inflammatory Disease Development Is Enhanced...mentioning

confidence: 99%

Pesticides and Their Impairing Effects on Epithelial Barrier Integrity, Dysbiosis, Disruption of the AhR Signaling Pathway and Development of Immune-Mediated Inflammatory Diseases

Lima

Falcão

Rosa

et al. 2022

IJMS

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The environmental and occupational risk we confront from agricultural chemicals increases as their presence in natural habitats rises to hazardous levels, building a major part of the exposome. This is of particular concern in low- and middle-income countries, such as Brazil, known as a leading producer of agricultural commodities and consumer of pesticides. As long as public policies continue to encourage the indiscriminate use of pesticides and governments continue to support this strategy instead of endorsing sustainable agricultural alternatives, the environmental burden that damages epithelial barriers will continue to grow. Chronic exposure to environmental contaminants in early life can affect crucial barrier tissue, such as skin epithelium, airways, and intestine, causing increased permeability, leaking, dysbiosis, and inflammation, with serious implications for metabolism and homeostasis. This vicious cycle of exposure to environmental factors and the consequent damage to the epithelial barrier has been associated with an increase in immune-mediated chronic inflammatory diseases. Understanding how the harmful effects of pesticides on the epithelial barrier impact cellular interactions mediated by endogenous sensors that coordinate a successful immune system represents a crucial challenge. In line with the epithelial barrier hypothesis, this narrative review reports the available evidence on the effects of pesticides on epithelial barrier integrity, dysbiosis, AhR signaling, and the consequent development of immune-mediated inflammatory diseases.

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Pesticide Exposure and Risk of Rheumatoid Arthritis: A Systematic Review and Meta-Analysis

Cited by 6 publications

References 38 publications

Exposure to organophosphate insecticides, inappropriate personal protective equipment use, and cognitive performance among pesticide applicators

Exposure to organophosphate insecticides, inappropriate personal protective equipment use, and cognitive performance among pesticide applicators

Gene–environment interactions increase the risk of paediatric-onset multiple sclerosis associated with household chemical exposures

Pesticides and Their Impairing Effects on Epithelial Barrier Integrity, Dysbiosis, Disruption of the AhR Signaling Pathway and Development of Immune-Mediated Inflammatory Diseases

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