A combination of inhibiting microglia activity and remodeling gut microenvironment suppresses the development and progression of experimental autoimmune uveitis

Yang, Jingjing; Lin, Dan; Zhang, Renshu; Liu, Hui; Yu, Ailing; Vakal, Serhii; Li, Xingyi

doi:10.1016/j.bcp.2020.114108

Cited by 24 publications

(15 citation statements)

References 75 publications

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“…Oral administration of minocycline also conferred a higher abundance of intestinal Parabacteroides goldsteinii than placebo-treated EAU [36]. Furthermore, minocycline treatment significantly attenuated EAU disease severity [35]. However, this remains the only evidence of beneficial effects for antibiotic treatment in intestinal dysbiosis and ocular disease.…”

Section: Antibiotics Treatmentmentioning

confidence: 96%

“…In experiments, minocycline treatment was shown to restore the relative abundance of Ruminococcus bromii, Streptococcus hyointestinalis, and Desulfovibrio sp. ABHU2SB and thus can remodel the gut microenvironment of EAU rats [35]. Oral administration of minocycline also conferred a higher abundance of intestinal Parabacteroides goldsteinii than placebo-treated EAU [36].…”

Section: Antibiotics Treatmentmentioning

confidence: 97%

“…The combined administration of an antibiotic cocktail containing ampicillin, gentamicin, metronidazole, neomycin, and vancomycin reduces microbiome diversity and shifts the composition of gut microbiota [43,44], which in turn results in dysregulation of the host immune homeostasis and leads to an increased susceptibility to disease. On the other hand, however, the antibiotic minocycline is able to restore the architecture of gut microbiota in EAU rats, thereby ameliorating disease [35]. Thus, the jury is still out on the use of antibiotics for such purposes.…”

Section: Implications On Existing Therapymentioning

confidence: 99%

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A Review of the Impact of Alterations in Gut Microbiome on the Immunopathogenesis of Ocular Diseases

Chan

Wong

et al. 2021

JCM

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Recent studies have highlighted the association between ocular diseases and microbiota profiles of the host intestinal tract and oral cavity. There is mounting evidence supporting the existence of a ‘gut–eye axis’, whereby changes in gut microbiome alter host immunity, with consequential implications for ocular health and disease. In this review, we examined recent published findings on the association between gut microbiome and ocular morbidity, based on 25 original articles published between 2011 to 2020. The review included both clinical and in vivo animal studies, with particular focus on the influence of the microbiome on host immunity and metabolism. Significant associations between altered intestinal microbiome and specific ocular diseases and pathological processes, including Behçet’s syndrome, autoimmune uveitis, age-related macular degeneration, choroidal neovascularization, bacterial keratitis, and Sjögren-like lacrimal keratoconjunctivitis have been demonstrated. Furthermore, alterations in the gut microbiome resulted in quantifiable changes in the host immune response, suggesting immunopathogenesis as the basis for the link between intestinal dysbiosis and ocular disease. We also examined and compared different techniques used in the identification and quantification of gut microorganisms. With our enhanced understanding of the potential role of gut commensals in ophthalmic disease, the stage is set for further studies on the underlying mechanisms linking the gut microbiome, the host immune response, and the pathogenesis of ophthalmic disease.

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Section: Antibiotics Treatmentmentioning

confidence: 96%

Section: Antibiotics Treatmentmentioning

confidence: 97%

Section: Implications On Existing Therapymentioning

confidence: 99%

See 1 more Smart Citation

A Review of the Impact of Alterations in Gut Microbiome on the Immunopathogenesis of Ocular Diseases

Chan

Wong

et al. 2021

JCM

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“…Notably, antibiotics applied through the intraperitoneal route have limited effects on eliminating commensals and do not alter disease progression in EAU, suggesting that the amelioration of EAU by antibiotic treatment is not due to the anti-inflammatory effects of antibiotics themselves ( Nakamura et al., 2016 ). In another study, combining remodeling of the gut microbiome with immunosuppressive therapy significantly hindered the progression of EAU after inflammation onset ( Zhou et al., 2020 ). The microbiome of EAU mice is distinct from that of controls ( Horai and Caspi, 2019 ), which could be a result of robust immune activation by CFA.…”

Section: Role Of Microbiota In Ocular Diseasementioning

confidence: 99%

Microbiota and Ocular Diseases

Xue

Zou

et al. 2021

Front. Cell. Infect. Microbiol.

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Recent advances have identified significant associations between the composition and function of the gut microbiota and various disorders in organ systems other than the digestive tract. Utilizing next-generation sequencing and multiomics approaches, the microbial community that possibly impacts ocular disease has been identified. This review provides an overview of the literature on approaches to microbiota analysis and the roles of commensal microbes in ophthalmic diseases, including autoimmune uveitis, age-related macular degeneration, glaucoma, and other ocular disorders. In addition, this review discusses the hypothesis of the “gut-eye axis” and evaluates the therapeutic potential of targeting commensal microbiota to alleviate ocular inflammation.

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“…This is presumably due to the reason that host microbiota could shape the host immune system to dictate the proinflammatory effects of other proinflammatory stimuli (128). A recent study demonstrated that the combination of remodeling of gut microbiome and microglia inhibition significantly attenuate the progression of EAU after inflammation onset (129). A potential explanation is that antigens from commensals reprogram naïve CD4 + T cells to the regulatory T cells lineage to restrain lymphocyte response (130).…”

Section: Targeting Ocular Microbiota As Novel Therapies For Intraoculmentioning

confidence: 99%

Ocular Microbiota and Intraocular Inflammation

Wei

2020

Front. Immunol.

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The term ocular microbiota refers to all types of commensal and pathogenic microorganisms present on or in the eye. The ocular surface is continuously exposed to the environment and harbors various commensals. Commensal microbes have been demonstrated to regulate host metabolism, development of immune system, and host defense against pathogen invasion. An unbalanced microbiota could lead to pathogenic microbial overgrowth and cause local or systemic inflammation. The specific antigens that irritate the deleterious immune responses in various inflammatory eye diseases remain obscure, while recent evidence implies a microbial etiology of these illnesses. The purpose of this review is to provide an overview of the literature on ocular microbiota and the role of commensal microbes in several eye diseases. In addition, this review will also discuss the interaction between microbial pathogens and host factors involved in intraocular inflammation, and evaluate therapeutic potential of targeting ocular microbiota to treat intraocular inflammation.

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A combination of inhibiting microglia activity and remodeling gut microenvironment suppresses the development and progression of experimental autoimmune uveitis

Cited by 24 publications

References 75 publications

A Review of the Impact of Alterations in Gut Microbiome on the Immunopathogenesis of Ocular Diseases

A Review of the Impact of Alterations in Gut Microbiome on the Immunopathogenesis of Ocular Diseases

Microbiota and Ocular Diseases

Ocular Microbiota and Intraocular Inflammation

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