A colorimetric electronic tongue based on bi-functionalized AuNPs for fingerprint detection of cancer markers

Bordbar, Mohammad Mahdi; Samadinia, Hossein; Sheini, Azarmidokht; Halabian, Raheleh; Parvin, Shahram; Ghanei, Mostafa; Bagheri, Hasan

doi:10.1016/j.snb.2022.132170

Cited by 17 publications

(7 citation statements)

References 28 publications

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“…In this model, when four antigens with different chemical structures and sizes interact with nanoparticles that have a stabilized distribution at a specific detection site on paper, the repulsion between the nanoparticles decreases as steric hindrance is eliminated and the color of the receptor changes from red to purple, as in Figure 4 (2). The resulting colors are then analyzed with Image J software [ 105 ].…”

Section: Signal Detection Techniquesmentioning

confidence: 99%

“… ( 1 ) Detection of tumor-specific anti-p53 autoantibodies (anti-p53aAbs) (reprinted with permission from [ 104 ]; copyright 2022, Elsevier); ( 2 ) colorimetric cancer detection system called fingerprint response model (a) fabrication and application of the proposed sensor array and (b) interaction of sensor components and CA-125 cancer marker. (reprinted with permission from [ 105 ]; copyright 2022, Elsevier). …”

Section: Figurementioning

confidence: 99%

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Biomarker Detection in Early Diagnosis of Cancer: Recent Achievements in Point-of-Care Devices Based on Paper Microfluidics

et al. 2023

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Microfluidics is very crucial in lab-on-a-chip systems for carrying out operations in a large-scale laboratory environment on a single chip. Microfluidic systems are miniaturized devices in which the fluid behavior and control can be manipulated on a small platform, with surface forces on the platform being greater than volumetric forces depending on the test method used. In recent years, paper-based microfluidic analytical devices (μPADs) have been developed to be used in point-of-care (POC) technologies. μPADs have numerous advantages, including ease of use, low cost, capillary action liquid transfer without the need for power, the ability to store reagents in active form in the fiber network, and the capability to perform multiple tests using various measurement techniques. These benefits are critical in the advancement of paper-based microfluidics in the fields of disease diagnosis, drug application, and environment and food safety. Cancer is one of the most critical diseases for early detection all around the world. Detecting cancer-specific biomarkers provides significant data for both early diagnosis and controlling the disease progression. μPADs for cancer biomarker detection hold great promise for improving cure rates, quality of life, and minimizing treatment costs. Although various types of bioanalytical platforms are available for the detection of cancer biomarkers, there are limited studies and critical reviews on paper-based microfluidic platforms in the literature. Hence, this article aims to draw attention to these gaps in the literature as well as the features that future platforms should have.

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Section: Signal Detection Techniquesmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Biomarker Detection in Early Diagnosis of Cancer: Recent Achievements in Point-of-Care Devices Based on Paper Microfluidics

et al. 2023

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“…A unique feature of paper is its flexibility, allowing for making three-dimensional (3D) origami sensors associated with the vertical transfer of the sample along multiple layers of paper 24 . Origami (or 3D) systems are recommended in the preparation of sensors based on disease diagnosis, thereby reducing and even eliminating the effect of color, turbidity and viscosity of biological samples on the response of the sensor 23 .…”

Section: Introductionmentioning

confidence: 99%

An origami-based colorimetric sensor for detection of hydrogen peroxide and glucose using sericin capped silver nanoparticles

Mirzaei

Gholami

Sheini

et al. 2023

Sci Rep

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The hydrogen peroxide (H2O2) measurement is considered highly important in industrial wastewater quality assessment, environmental protection, and disease detection. Here, a simple high-performance paper-based sensor is proposed for rapid and in situ detection of H2O2. To this end, 3,3′,5,5′-tetramethylbenzidine is embedded in the sensor to act as a color indicator, whose reaction with hydrogen peroxide is catalyzed by a silver nanozyme modified by sericin. The result of the reaction clarified by the appearance of blue color in the sensor detection zone is received by a portable scanner, while also calculating its intensity by image analysis software. This method is sensitive to hydrogen peroxide in the concentration range of 0.5‒240 mg/dL, providing a detection limit of 0.15 mg/dL. The ability of the sensor to determine glucose is also evaluated by adding a layer containing glucose oxidase enzyme to the sensor structure. A desirable response is obtained in the range of 1.0‒160 mg/dL, together with a detection limit of 0.37 mg/dL. Accordingly, the proposed sensor shows satisfactory results compared to clinical methods for monitoring the amount of glucose in biological samples such as serum and saliva.

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“…The development of colorimetric methods is promising for the diagnosis of diseases, especially in a pandemic situation when mass testing is necessary [ 8 , 9 ]. These can be simple, portable, and economical, and can present high selectivity, with the possibility of making the diagnosis visually.…”

Section: Introductionmentioning

confidence: 99%

Molecular test for COVID-19 diagnosis based on a colorimetric genomagnetic assay

Oliveira

Leite

Miranda

et al. 2023

Analytica Chimica Acta

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A colorimetric electronic tongue based on bi-functionalized AuNPs for fingerprint detection of cancer markers

Cited by 17 publications

References 28 publications

Biomarker Detection in Early Diagnosis of Cancer: Recent Achievements in Point-of-Care Devices Based on Paper Microfluidics

Biomarker Detection in Early Diagnosis of Cancer: Recent Achievements in Point-of-Care Devices Based on Paper Microfluidics

An origami-based colorimetric sensor for detection of hydrogen peroxide and glucose using sericin capped silver nanoparticles

Molecular test for COVID-19 diagnosis based on a colorimetric genomagnetic assay

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