A closer look at the Autism Behavior Checklist: Discriminant validity and factor structure

Wadden, Norma P.; Bryson, Susan E.; Rodger, R. S.

doi:10.1007/bf02206875

Cited by 77 publications

(47 citation statements)

References 9 publications

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“…The presence of autistic symptoms in subjects with FraX was measured with the Autism Behavior Checklist (ABC), 19 whereas maladaptive behaviors associated with developmental disability were measured with the Aberrant Behavior Checklist (AbBC). 20 Higher scores on the ABC and AbBC indicate greater impairment.…”

Section: Cognitive-behavioral Assessmentmentioning

confidence: 99%

Neuroanatomy of fragile X syndrome is associated with aberrant behavior and the fragile X mental retardation protein (FMRP)

Gothelf

Furfaro

Hoeft

et al. 2007

Annals of Neurology

175

161

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Objective-To determine how neuroanatomic variation in children and adolescents with fragile X syndrome is linked to reduced levels of the fragile X mental retardation-1 protein and to aberrant cognition and behavior.Methods-This study included 84 children and adolescents with the fragile X full mutation and 72 typically developing control subjects matched for age and sex. Brain morphology was assessed with volumetric, voxel-based, and surface-based modeling approaches. Intelligence quotient was evaluated with standard cognitive testing, whereas abnormal behaviors were measured with the Autism Behavior Checklist and the Aberrant Behavior Checklist.Results-Significantly increased size of the caudate nucleus and decreased size of the posterior cerebellar vermis, amygdala, and superior temporal gyrus were present in the fragile X group. Subjects with fragile X also demonstrated an abnormal profile of cortical lobe volumes. A receiver operating characteristic analysis identified the combination of a large caudate with small posterior cerebellar vermis, amygdala, and superior temporal gyrus as distinguishing children with fragile X from control subjects with a high level of sensitivity and specificity. NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript cerebellar vermis were associated with lower fragile X mental retardation protein levels and more pronounced cognitive deficits and aberrant behaviors.Interpretation-Abnormal development of specific brain regions characterizes a neuroanatomic phenotype associated with fragile X syndrome and may mediate the effects of FMR1 gene mutations on the cognitive and behavioral features of the disorder. Fragile X syndrome provides a model for elucidating critical linkages among gene, brain, and cognition in children with serious neurodevelopmental disorders.Cognitive dysfunction and aberrant behaviors are the hallmarks of childhood neurodevelopmental disorders. Though current diagnostic constructs for these disorders are useful for professional communication and obtaining therapeutic services, the current taxonomic categories are likely to be too heterogeneous to support scientific investigation. 1 More homogeneous models are needed to overcome the problem of heterogeneity in our current taxonomy of neurodevelopmental disorders, so that genetic and neural mechanisms underlying the development and course of maladaptive cognition and behavior can be determined. 2Fragile X syndrome (FraX) is caused by a mutation in the FMR1 gene on chromosome Xq27.3; it is the most common known cause of inherited neurodevelopmental disability. As a causatively homogeneous disorder where affected children share a common genetic risk factor, FraX is a valuable model from which to learn about pathways leading from specific gene mutation to aberrant brain development and cognitive-behavioral symptoms. 2 Accordingly, the aim of this study was to determine the associations among levels of FMRP, neuroanatomic variation, and aberrant cognition and behavior in FraX using multi...

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Section: Cognitive-behavioral Assessmentmentioning

confidence: 99%

Neuroanatomy of fragile X syndrome is associated with aberrant behavior and the fragile X mental retardation protein (FMRP)

Gothelf

Furfaro

Hoeft

et al. 2007

Annals of Neurology

175

161

View full text Add to dashboard Cite

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“…Several studies have demonstrated that the rate of both false positives and false negatives produced by the Autism Behavior Checklist is quite high and that most higher functioning children are not identified by the cutoff of 67 (Sevin, Matson, Coe, Fee, & Sevin, 1991;Sponheun & Spurkland, 1996;Volkmar et al, 1988;Wadden, Bryson, & Rodger, 1991), Therefore, it is not recommended for use.…”

Section: Autism Diagnostic Measurementmentioning

confidence: 99%

Evidence-Based Assessment of Autism Spectrum Disorders in Children and Adolescents

Ozonoff¹,

Goodlin‐Jones²,

Solomon³

2005

Journal of Clinical Child & Adolescent Psychology

342

252

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“…[13][14][16][17][18][19] The results of such studies, however, vary significantly regarding the sample selection criteria and methodology.…”

Section: -21mentioning

confidence: 99%

“…Two studies [13][14][15][16][17][18][19][20][21] correctly classified 100% and 85%, respectively, of the children evaluated. However, such results were not obtained in other studies, [14][15][16][17] in which only 50% of the children were correctly classified. Neither speaking nor nonspeaking autistic children were correctly classified at cutoff point 68.…”

Section: -7mentioning

confidence: 99%

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Validity of Autism Behavior Checklist (ABC): preliminary study

Marteleto

Pedromônico

2005

Rev. Bras. Psiquiatr.

102

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A b s t r a c t Objective: To examine the concurrent and criterion validity of the Autism Behavior Checklist (ABC). Methods: Three groups, comprising 38 mothers of children previously diagnosed with autism (DSM IV-TR, 2002), 43 mothers of children with language disorders other than autism, and 52 mothers of children who had no linguistic or behavioral complaints, were interviewed. In order to minimize the effect of maternal level of education, the questionnaire was completed by the researcher. To determine the concurrent validation, ANOVA and discriminant analysis were used. The ROC curve was used to establish the cutoff score of the sample and to examine the criterion validity. Results: The mean total score was significantly higher in the group of mothers of autistic children than in the other groups. The ABC correctly identified 81.6% of the autistic children. The ROC curve cutoff score was 49, and the sensitivity was 92.1%, higher than the 57.89% found when a cutoff score of 68 was used. The specificity was 92.6%, similar to the 94.73% obtained with a cutoff score of 68. Conclusions: The ABC shows promise as an instrument for identifying children with autistic disorders, both in clinical and educational contexts, especially when a cutoff score of 49 is used.

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A closer look at the Autism Behavior Checklist: Discriminant validity and factor structure

Cited by 77 publications

References 9 publications

Neuroanatomy of fragile X syndrome is associated with aberrant behavior and the fragile X mental retardation protein (FMRP)

Neuroanatomy of fragile X syndrome is associated with aberrant behavior and the fragile X mental retardation protein (FMRP)

Evidence-Based Assessment of Autism Spectrum Disorders in Children and Adolescents

Validity of Autism Behavior Checklist (ABC): preliminary study

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