Evidence-Based Assessment of Autism Spectrum Disorders in Children and Adolescents

Ozonoff, Sally J; Goodlin‐Jones, Beth L.; Solomon, Marjorie

doi:10.1207/s15374424jccp3403_8

Cited by 342 publications

(267 citation statements)

References 144 publications

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“…Social behavior and related parameters were analyzed along two axes, skills or abilities (e.g., adaptive socialization skills) and problem/aberrant behavior (e.g., social withdrawal), which were related to central ''gold standard'' measures of autistic behavior (e.g., ADI-R) and to DSM-IV diagnostic criteria. Supporting this scheme are our findings of parallel continua of severity of the aforementioned social behavior parameters and autistic behavior impairment by DSM-IV/ADI-R , and current views on evidence-based research on idiopathic ASD [Ozonoff et al, 2005].…”

Section: Subjectssupporting

confidence: 62%

Autism spectrum disorder in Fragile X syndrome: Differential contribution of adaptive socialization and social withdrawal

Budimirović

Bukelis

Cox

et al. 2006

American J of Med Genetics Pt A

130

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The present study extends our previous work on characterizing the profile of social behavior abnormalities in boys with Fragile X (FraX) and autism spectrum disorder (ASD) using clinically oriented behavioral rating scales and standardized instruments. The goal was to further distinguish behavioral parameters contributing to the diagnostic classification of FraX þ ASD. The study design included two cohorts of boys with FraX (3-8 years), a larger main cohort for crosssectional analyses (n ¼ 56, 24 with ASD), and a longitudinal subset (n ¼ 30, 11 with ASD) of the main cohort with up to 3 yearly observations. The focus was on the relative contribution of delayed adaptive socialization and social withdrawal, including item components of their corresponding rating instruments, to the diagnosis of ASD in boys with FraX. Using a combination of regression analyses, we demonstrated that: (1) as delayed socialization, social withdrawal is also a correlate of FraX þ ASD; (2) items of social withdrawal scales representing avoidance were the main predictors of ASD status, particularly in older boys; (3) adaptive socialization skills reflecting rules of social behavior and recognition and labeling of emotions, linked to verbal reasoning abilities, were selectively associated with FraX þ ASD; (4) adaptive socialization is the primary determinant over time of ASD status in boys with FraX; and (5) integrated adaptive socialization-social withdrawal models allow the identification of distinctive FraX þ ASD subgroups. Altogether, our findings suggest that two distinct but interrelated social behavior abnormalities, one linked to impaired cognitive processes (delayed socialization) and the second one to disturbance in limbic circuits (avoidance), play a role in the development of ASD in boys with FraX.

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Section: Subjectssupporting

confidence: 62%

Autism spectrum disorder in Fragile X syndrome: Differential contribution of adaptive socialization and social withdrawal

Budimirović

Bukelis

Cox

et al. 2006

American J of Med Genetics Pt A

130

View full text Add to dashboard Cite

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“…Finally, the child had to meet criteria for a diagnosis of either Autism or Autism Spectrum Disorder on the Autism Diagnostic Observation Schedule-General (ADOS-G; Lord et al 2002), Module 4. The ADOS-G is a gold standard of ASD evaluation (Ozonoff et al 2005), and trained members of the PEERS team who had established ADOS coding reliability completed administration of the ADOS-G. Of note, given that this study was commenced prior the publication of the DSM-5, it is not clear whether all participants would meet new criteria for an ASD diagnosis given the required presence of restricted or repetitive interest and behaviors. An additional requirement was that teens not have comorbid severe mental health disorders (e.g., psychotic disorders).…”

Section: Randomization and Inclusion Criteriamentioning

confidence: 99%

“…Parenting stress as assessed by the SIPA has been found to relate to the quality of parents' perceptions of their parenting alliance, other psychological measures of adolescent and parent functioning, and the quality of the marital relationship and family system (Sheras et al 1998). Ozonoff et al (2005) identified the SIPA as a psychometrically sound measure for use with parents of adolescents with ASD. Within this study, Cronbach's alpha suggested strong internal consistency (.95) at pre and post intervention.…”

Section: Stress Index For Parents Of Adolescents (Sipa)mentioning

confidence: 99%

Parent and Family Outcomes of PEERS: A Social Skills Intervention for Adolescents with Autism Spectrum Disorder

Karst

Hecke

Carson

et al. 2014

J Autism Dev Disord

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Raising a child with an Autism Spectrum Disorder (ASD) is associated with increased family chaos and parent distress. Successful longterm treatment outcomes are dependent on healthy systemic functioning, but the family impact of treatment is rarely evaluated. The Program for the Education and Enrichment of Relational Skills (PEERS) is a social skills intervention designed for adolescents with high-functioning ASD. This study assessed the impact of PEERS on family chaos, parenting stress, and parenting self-efficacy via a randomized, controlled trial. Results suggested beneficial effects for the experimental group in the domain of family chaos compared to the waitlist control, while parents in the PEERS experimental group also demonstrated increased parenting self-efficacy. These findings highlight adjunctive family system benefits of PEERS intervention and suggest the need for overall better understanding of parent and family outcomes of ASD interventions.

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“…3 Behavioral intervention is more effective the earlier it is initiated. [4][5][6][7] Therefore, the identification of biological markers of autism would have a number of ramifications: markers could assist in the early and accurate diagnosis of the disorder; they may identify particular biological targets for treatment; and they could be used to define subgroups for specific treatments as well as for genetic studies.…”

Section: Introductionmentioning

confidence: 99%

A proteomic study of serum from children with autism showing differential expression of apolipoproteins and complement proteins

Corbett

Kantor²,

Schulman³

et al. 2006

Mol Psychiatry

165

115

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Modern methods that use systematic, quantitative and unbiased approaches are making it possible to discover proteins altered by a disease. To identify proteins that might be differentially expressed in autism, serum proteins from blood were subjected to trypsin digestion followed by liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS) on time-of-flight (TOF) instruments to identify differentially expressed peptides. Children with autism 4-6 years of age (n = 69) were compared to typically developing children (n = 35) with similar age and gender distributions. A total of 6348 peptide components were quantified. Of these, five peptide components corresponding to four known proteins had an effect size > 0.99 with a P < 0.05 and a Mascot identification score of 30 or greater for autism compared to controls. The four proteins were: Apolipoprotein (apo) B-100, Complement Factor H Related Protein (FHR1), Complement C1q and Fibronectin 1 (FN1). In addition, apo B-100 and apo A-IV were higher in children with high compared to low functioning autism. Apos are involved in the transport of lipids, cholesterol and vitamin E. The complement system is involved in the lysis and removal of infectious organisms in blood, and may be involved in cellular apoptosis in brain. Despite limitations of the study, including the low fold changes and variable detection rates for the peptide components, the data support possible differences of circulating proteins in autism, and should help stimulate the continued search for causes and treatments of autism by examining peripheral blood.

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Evidence-Based Assessment of Autism Spectrum Disorders in Children and Adolescents

Abstract: This article reviews evidence-based criteria that can guide practitioners in the selection, use, and interpretation of assessment tools for autism spectrum disorders (ASD). As Mash and Hunsley (2005)

Cited by 342 publications

References 144 publications

Autism spectrum disorder in Fragile X syndrome: Differential contribution of adaptive socialization and social withdrawal

Autism spectrum disorder in Fragile X syndrome: Differential contribution of adaptive socialization and social withdrawal

Parent and Family Outcomes of PEERS: A Social Skills Intervention for Adolescents with Autism Spectrum Disorder

A proteomic study of serum from children with autism showing differential expression of apolipoproteins and complement proteins

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